Skip to main content
Log in

Infektionen als Ursache von Fieber unklarer Genese

Infections as causes of fever of unknown origin

  • Schwerpunkt: Fieber unklarer Genese
  • Published:
Der Internist Aims and scope Submit manuscript

Zusammenfassung

Das Spektrum von Infektionen als Ursache eines Fiebers unklarer Genese ist breit und hängt von individuellen Risikofaktoren der Patienten ab. Die zugrunde liegenden Infektionen zeigen dabei oft atypische Verlaufsformen. Eine Unterteilung in ambulante, nosokomiale und Infektionen bei immunkompromittierten Patienten strukturiert das Krankheitsbild und auch das differenzialdiagnostische Vorgehen sinnvoll. Wir geben einen Überblick über die wichtigsten infektiösen Ursachen eines Fiebers unklarer Genese.

Abstract

Infectious diseases are important causes of fever of unknown origin (FUO). The spectrum of infectious agents is broad and diagnosis depends on careful evaluation of individual risk factors. Infectious diseases presenting as FUO are frequently atypical presentations of well known infections, e.g. tuberculosis or infectious endocarditis. In this review we present an overview of infectious causes of FUO classified into community acquired infections, nosocomial infections, and infections in immunocompromised hosts.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Armstrong WS, Katz JT, Kazanjian PH (1999) Human immunodeficiency virus-associated fever of unknown origin: A study of 70 patients in the United States and review. Clin Infect Dis 28: 341–345

    Article  PubMed  CAS  Google Scholar 

  2. Bansal C, Scott R, Stewart D, Cockerell CJ (2005) Decubitus ulcers: A review of the literature. Int J Dermatol 44: 805–810

    Article  PubMed  Google Scholar 

  3. Bouza E, Loeches B, Munoz P (2007) Fever of unknown origin in solid organ transplant recipients. Infect Dis Clin North Am 21: 1033–1054

    Article  PubMed  Google Scholar 

  4. Durack DT, Street AC (1991) Fever of unknown origin-reexamined and redefined. Curr Clin Top Infect Dis 11: 35–51

    PubMed  CAS  Google Scholar 

  5. Ellis ME, Al-Abdely H, Sandridge A et al. (2001) Fungal endocarditis: Evidence in the world literature, 1965–1995. Clin Infect Dis 32: 50–62

    Article  PubMed  CAS  Google Scholar 

  6. Fischer SA, Graham MB, Kuehnert MJ et al. (2006) Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med 354: 2235–2249

    Article  PubMed  CAS  Google Scholar 

  7. George DL, Falk PS, Umberto Meduri G et al. (1998) Nosocomial sinusitis in patients in the medical intensive care unit: A prospective epidemiological study. Clin Infect Dis 27: 463–470

    Article  PubMed  CAS  Google Scholar 

  8. Gluck T, Kiefmann B, Grohmann M et al. (2005) Immune status and risk for infection in patients receiving chronic immunosuppressive therapy. J Rheumatol 32: 1473–1480

    PubMed  Google Scholar 

  9. Houff SA, Burton RC, Wilson RW et al. (1979) Human-to-human transmission of rabies virus by corneal transplant. N Engl J Med 300: 603–604

    PubMed  CAS  Google Scholar 

  10. Kazanjian PH (1992) Fever of unknown origin: Review of 86 patients treated in community hospitals. Clin Infect Dis 15: 968–973

    PubMed  CAS  Google Scholar 

  11. Kitkungvan D, Apisarnthanarak A, Plengpart P, L M M (2008) Fever of unknown origin in patients with HIV infection in Thailand: An observational study and review of the literature. Int J STD AIDS 19: 232–235

    Article  PubMed  Google Scholar 

  12. Klastersky J, Paesmans M, Rubenstein EB et al. (2000) The Multinational Association for Supportive Care in Cancer risk index: A multinational scoring system for identifying low-risk febrile neutropenic cancer patients. J Clin Oncol 18: 3038–3051

    PubMed  CAS  Google Scholar 

  13. Link H, Bohme A, Cornely OA et al. (2003) Antimicrobial therapy of unexplained fever in neutropenic patients-guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO), Study Group Interventional Therapy of Unexplained Fever, Arbeitsgemeinschaft Supportivmassnahmen in der Onkologie (ASO) of the Deutsche Krebsgesellschaft (DKG-German Cancer Society). Ann Hematol 82 (Suppl 2): S105–S117

    Article  PubMed  CAS  Google Scholar 

  14. Petersdorf RG, Beeson PB (1961) Fever of unexplained origin: Report on 100 cases. Medicine 40: 1–30

    Article  PubMed  CAS  Google Scholar 

  15. Schiel X, Link H, Maschmeyer G et al. (2006) A prospective, randomized multicenter trial of the empirical addition of antifungal therapy for febrile neutropenic cancer patients: Results of the Paul Ehrlich Society for Chemotherapy (PEG) Multicenter Trial II. Infection 34: 118–126

    Article  PubMed  CAS  Google Scholar 

  16. Selton-Suty C, Hoen B, Grentzinger A et al. (1997) Clinical and bacteriological characteristics of infective endocarditis in the elderly. Heart 77: 260–263

    Article  PubMed  CAS  Google Scholar 

  17. Shively BK, Gurule FT, Roldan CA et al. (1991) Diagnostic value of transesophageal compared with transthoracic echocardiography in infective endocarditis. J Am Coll Cardiol 18: 391–397

    Article  PubMed  CAS  Google Scholar 

  18. Sipahi OR, Senol S, Arsu G et al. (2007) Pooled analysis of 857 published adult fever of unknown origin cases in Turkey between 1990-2006. Med Sci Monit 13: CR318–322

    PubMed  Google Scholar 

  19. Wanahita A, Goldsmith EA, Marino BJ, Musher DM (2003) Clostridium difficile infection in patients with unexplained leukocytosis. Am J Med 115: 543–546

    Article  PubMed  Google Scholar 

  20. Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections. N Engl J Med 351: 1645–1654

    Article  PubMed  CAS  Google Scholar 

Download references

Interessenkonflikt

Für keinen der beteiligten Autoren besteht ein Interessenkonflikt durch in diesem Artikel beschriebene Produkte.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B. Salzberger.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schneidewind, A., Ehrenstein, B. & Salzberger, B. Infektionen als Ursache von Fieber unklarer Genese. Internist 50, 659–667 (2009). https://doi.org/10.1007/s00108-009-2305-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00108-009-2305-2

Schlüsselwörter

Keywords

Navigation