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The results of fat tolerance tests and blood sugar estimations performed on patients affected with peptic ulcer

With a discussion of factors possible in the etiology of peptic ulcer

  • Clinical Medicine: Diseases Of Digestion
  • Published:
The American Journal of Digestive Diseases

Summary and Conclusions

Measures that include diversion of bile from the duodenum or injury to the liver have been found to produce chronic peptic ulcers in dogs. The possiblerôles of bile in the prevention of ulcers are discussed. That loss of bile from the duodenum may result in lowered tissue resistance because of a disturbed fat metabolism is considered.

On this basis, we have made a study of fat tolerance tests done on 20 patients affected with peptic ulcer. These curves showed no significant differences from those of a group of 10 normal persons. These data seem to preclude any gross disturbances in digestion, absorption and metabolism of fat in such patients. However, they do not rule out the possibility that disturbances of fat may be present which cannot be recognized by the Rückerthemolipokrit method, used in this study. Comparative studies of the quality and nature of the lipoid constituents of cells of the ulcer-bearing areas in patients with and without ulcer, might throw further light on the subject.

Over a six-hour period, no differences could be observed in the blood sugar curves of patients with peptic ulcer compared with normal individuals, following the ingestion of 100 grams of fat.

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Authors and Affiliations

  1. Boston, Massachusetts

    Maurice A. Schnitker M.D. & E. S. Emery M.D.

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  1. Maurice A. Schnitker M.D.
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  2. E. S. Emery M.D.
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From the Medical Clinic of the Peter Bent Brigham Hospital.

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Schnitker, M.A., Emery, E.S. The results of fat tolerance tests and blood sugar estimations performed on patients affected with peptic ulcer. American Journal of Digestive Diseases and Nutrition 1, 834–840 (1934). https://doi.org/10.1007/BF02999006

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  • DOI: https://doi.org/10.1007/BF02999006

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