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Thyroid multifocal granulomatous folliculitis (palpation thyroiditis): An immunocytochemical study

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Abstract

We analyzed lymphoid cell populations from thyroid multifocal granulomatous folliculitis (palpation thyroiditis) with a panel of antibodies in order to assess the nature of the immunologic process underlying this otherwise clinically insignificant condition as compared with other specific types of thyroiditis. In general, T lymphocytes predominated over B lymphocytes as shown by the extent of the staining with UCHL-1 (CD45RO or CD3 and L26 (CD20) antibodies, respectively. The ratio of kappa-to-lambda-containing plasma cells was 1.4 to 1. Histiocytes, macrophages, and multinucleate giant cells were all found to stain consistently strongly with KPI (CD68) and, when intraluminal, not infrequently also for thyroglobulin, probaby due to colloid phagocytosis. The differing patterns of light chain restriction observed in multifocal granulomatous folliculitis as compared with Riedel’s thyroiditis and Graves disease thyroiditis, for instance, may reflect differences in the nature of the underlying immune response.

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References

  1. Carney JA, Moore SB, Northcutt RC, Woolner LW, Stillwell GK. Palpation thyroiditis (multifocal granulomatous folliculitis). Am J Clin Pathol 64:639–647, 1975.

    Article  CAS  Google Scholar 

  2. Harach HR. Palpation thyroiditis resembling C cell hyperplasia: usefulness of immunohistochemistry in their differential diagnosis. Pathol Res Pract (in press).

  3. Harach HR, Williams ED. fibrous thyroiditis— an immunopathological study. Histopathology 7:739–751, 1983.

    Article  CAS  Google Scholar 

  4. Harach HR, Williams ED. The pathology of granulomatous diseases of the thyroid gland. Sarcoidosis 7:19–27, 1990.

    CAS  PubMed  Google Scholar 

  5. Knecht H, Saremaslani P, Hedinger C. Immunohistological findings in Hashimoto’s thyroiditis, focal lymphocytic thyroiditis and thyroiditis dc Quervain. Comparative study. Virchows Arch [A] 393:215–231, 1981.

    Article  CAS  Google Scholar 

  6. Martin Schwaegerle S, Bauer TW, Esselstyn CB. Riedel’s thyroiditis. Am J Clin Pathol 90:715–722, 1988.

    Article  Google Scholar 

  7. Mitchell JD, Kirkham N, Machin D. Focal lymphocytic thyroiditis in Southampton. J Pathol 144:269–273, 1984.

    Article  CAS  Google Scholar 

  8. Mizukami Y, Michigishi T, Hashimoto T, Tonami N, Hisada K, Matsubara F, Takazakura E. Silent thyroiditis: a histologic and immunohistochemical study. Hum Pathol 19:423–431, 1988.

    Article  CAS  Google Scholar 

  9. Smith CA, Jasani B, Williams ED. Lambda light chain restriction in the diffuse thyroid lymphoid infiltrate in untreated Graves’ disease. In: Pinchera A, Ingbar SH, Mc- Kenzie JM, Fenzi GF, eds. Thyroid autoimmunity. New York: Plenum Press, 1987: 335–337.

    Chapter  Google Scholar 

  10. Smyrk TC, Goellner JR, Brennan MD, Carney JA, Pathology of the thyroids in amiodarone-associated thyrotoxicosis. Am J Surg Pathol 11:197–204, 1987.

    Article  CAS  Google Scholar 

  11. Totterman TH, Gordin A, Hayry P, Andersson LC, Makinen T. Accumulation of thyroid antigen-reactive T lymphocytes in the gland of patients with subacute thyroiditis. Clin Exp Immunol 32:153–158, 1978.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Volpe R. Is silent thyroiditis an autoimmune disease? Arch Intern Med 148:1907–1908, 1988,

    Article  CAS  Google Scholar 

  13. Wick MR, Sawyer MD. Antigenic alterations in autoimmune thyroid disease. Observations and hypotheses. Arch Pathol Lab Med 113:77–81, 1989.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, University of Wales College of Medicine, Cardiff, UK

    H. Ruben Harach & Bharat Jasani

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  1. H. Ruben Harach
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  2. Bharat Jasani
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Harach, H.R., Jasani, B. Thyroid multifocal granulomatous folliculitis (palpation thyroiditis): An immunocytochemical study. Endocr Pathol 4, 105–109 (1993). https://doi.org/10.1007/BF02914460

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