Abstract
Pathological rupture of the spleen is a rare but well recognized complication in hematological malignancies. Early clinical recognition of this life-threatening complication is necessary for rapid intervention. Here, we report on the case of a 26-year-old woman with acute promyelocytic leukemia who presented rupture of the spleen on day +2 of treatment with ATRA plus idarrubicin. In patients with acute leukemia, the presence of a painful abdomen and a sudden drop in hemoglobin levels, should alert of a possible splenic rupture, even without additional symptoms. This would facilitate an early treatment intervention with no modification to the chemotherapy schedule.
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Hernández, R., del Cañizo, M., López, C. et al. Pathologic rupture of the spleen during induction with ATRA in a patient with acute promyelocytic leukemia. Med Oncol 17, 337–339 (2000). https://doi.org/10.1007/BF02782201
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DOI: https://doi.org/10.1007/BF02782201