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Simulation of the electric-control activity of the stomach by an array of relaxation oscillators

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Abstract

An array of bidirectionally coupled relaxation oscillators is proposed as a model of gastric electric-control activity. The characteristics of relaxation oscillators simulating control activity, such as intact and intrinsic frequency gradients and phase-lag patterns, were studied in anesthetized dogs. A marked intrinsic frequency gradient was found along the axis of the stomach, and a slight intrinsic frequency gradient around the circumference. The phase lag/cm decreased distally from the body of the stomach to the antrum. The model showed all these characteristics. Each oscillator in the array was represented by a system of two first-order nonlinear differential equations. The model was programmed on analog and hybrid computers.

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References

  1. Burnstock G, Holman ME, Prosser CL: Electrophysiology of smooth muscle. Physiol Rev 43:482, 1963

    PubMed  Google Scholar 

  2. Kelly KA, Code CF, Elveback LR: Patterns of canine gastric electrical activity. Am J Physiol 217:461, 1969

    PubMed  Google Scholar 

  3. Bass P, Code CF, Lambert EH: Motor and electric activity of the duodenum. Am J Physiol 201:587, 1961

    PubMed  Google Scholar 

  4. Kelly KA, Code CF: Canine gastric pacemaker. Am J Physiol 220:112, 1971

    PubMed  Google Scholar 

  5. Weber J Jr, Kohatsu S: Pacemaker localization and electrical conduction patterns in the canine stomach. Gastroenterology 59:717, 1970

    PubMed  Google Scholar 

  6. Daniel EE, Chapman KM: Electrical activity of the gastro-intestinal tract as an indication of mechanical activity. Am J Digest Dis 8:54–102, 1963

    PubMed  Google Scholar 

  7. Daniel EE, Wachter BT, Honour AJ, et al: The relationship between electrical and mechanical activity of the small intestine of dog and man. Can J Biochem Physiol 38:777, 1960

    PubMed  Google Scholar 

  8. Sarna SK, Daniel EE, Kingma YJ: Simulation of slow wave electrical activity of the small intestine. Am J Physiol 221:166, 1971

    PubMed  Google Scholar 

  9. Fitzhugh R: Impulses and physiological states in theoretical models of nerve membrane. Biophys J 1:445, 1961

    Google Scholar 

  10. Henderson RM, Duchon G, Daniel EE: Cell contacts in duodenal smooth muscle layers. Am J Physiol 221:564, 1971

    PubMed  Google Scholar 

  11. Yoshida K: Studies on the constitution of muscle layers of stomach of canine and human. Jap J Smooth Muscle Res 6:159, 1970

    Google Scholar 

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Authors and Affiliations

  1. From the Departments of Electrical Engineering and Pharmacology, The University of Alberta, Edmonton, Canada

    S. K. Sarna PhD, E. E. Daniel PhD & Y. J. Kingma LR

Authors
  1. S. K. Sarna PhD
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  2. E. E. Daniel PhD
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  3. Y. J. Kingma LR
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Additional information

Supported by the Medical Research Council of Canada, the Alberta Heart Foundation and the National Research Council of Canada.

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Sarna, S.K., Daniel, E.E. & Kingma, Y.J. Simulation of the electric-control activity of the stomach by an array of relaxation oscillators. Digest Dis Sci 17, 299–310 (1972). https://doi.org/10.1007/BF02231729

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  • DOI: https://doi.org/10.1007/BF02231729

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