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Cellular distribution of dexamethasone in rabbit spleen and lymph nodes

  • Immunosuppression and Inflammation
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Abstract

The binding of tritiated dexamethasone by rabbit spleen and lymph nodes was studiedin vivo by dry radioautography. The labeled glucocorticoid was found in the surface and cytoplasm of eosinophil leukocytes and in the nuclei of reticular cells, plasmocytes, endothelial cells and macrophages, but not in lymphocytes, lymphoblasts or plasmoblasts. Additional administration of excess of excess of non-radioactive dexamethasone suppressed this labeling. The findings are discussed in relation to the mechanism of action of glucocorticoids in lymphoid organs.

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Authors and Affiliations

  1. Laboratory of Experimental Endocrinology, Department of Experimental Morphology, University of Chile Medical School, Correo 21, Casilla 21104, Santiago, Chile

    Andrei N. Tchernitchin, M. Antonieta Castrillón & Angel Rodríguez

Authors
  1. Andrei N. Tchernitchin
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  2. M. Antonieta Castrillón
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  3. Angel Rodríguez
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Tchernitchin, A.N., Antonieta Castrillón, M. & Rodríguez, A. Cellular distribution of dexamethasone in rabbit spleen and lymph nodes. Agents and Actions 15, 588–593 (1984). https://doi.org/10.1007/BF01966779

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  • DOI: https://doi.org/10.1007/BF01966779

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