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Methods of investigation in the diagnosis and management of thyroid carcinoma

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Abstract

Preoperative investigation of thyroid nodules is discussed with emphasis on the use of radionuclide scanning, ultrasound examination, and x-ray fluorescence to decrease the need for unnecessary surgical excision. A follow-up program is described involving the use of 131 I imaging techniques and serial thyroglobulin measurements in patients postoperatively for evaluation of response to treatment and detection of recurrence.

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References

  1. Byar, D.P., Green, S.B., Dor, P., Williams, D., Colon, J., Grilse, H.A., van Mayer, M., Sylvester, R.J., Van Glabbeke, M.: A prognostic index for thyroid carcinoma. A study of the EORTC Thyroid Cancer Co-operative Group. Eur. J. Cancer15:1033, 1979

    Google Scholar 

  2. Perlmutter, M., Slater, S.L.: Which nodular goitres should be removed? N. Engl. J. Med.255:65, 1956

    Google Scholar 

  3. Andros, G., Harper, P.V., Lathrop, K.A., McCardle, R.J.: Pertechnetate-99m localization in man with applications to thyroid scanning and the study of thyroid physiology. J. Clin. Endocrinol. Metab.25:1067, 1965

    Google Scholar 

  4. Wagner, H.N., Jr.: The scintillation camera with pinhole collimator in thyroid imaging. Radiology101:133, 1971

    Google Scholar 

  5. Wellman, H.N., Anger, R.T., Jr.: Radioiodine dosimetry and the use of radioiodines other than I131 in thyroid diagnosis. Semin. Nucl. Med.1:356, 1971

    Google Scholar 

  6. Goolden, A.W.G., Glass, B.A., Silvester, D.J.: The choice of a radioactive isotope for the investigation of thyroid disorders. Br. J. Radiol.41:20, 1968

    Google Scholar 

  7. Maisey, M.N., Moses, D.C., Hurley, P.J., Wagner, H.N., Jr.: Improved methods for thyroid scanning. J.A.M.A.223:761, 1973

    Google Scholar 

  8. Ryo, U.Y., Arnold, J., Colman, M., Arnold, M., Favus, M., Frohman, L., Schneider, A., Stachura, M., Pinsky, S.: Thyroid scintigram. Sensitivity with Sodium Pertechnetate Tc99m and gamma camera with pinhole collimator. J.A.M.A.235:1235, 1976

    Google Scholar 

  9. Karelitz, J.R., Richards, J.B.: Necessity of oblique views in evaluating the functional status of a thyroid nodule. J. Nucl. Med.15:782, 1975

    Google Scholar 

  10. Frohman, L.A., Schneider, A.B., Favus, M.J., Stachura, M.E., Arnold, J., Arnold, M.: Thyroid carcinoma after head and neck irradiation evaluation of 1476 patients. In Radiation-Associated Thyroid Carcinoma, De Groot, L.J., Frohman, L.A., Kaplan, E.L., Refetoff, S., editors, New York, Grune & Stratton, 1977, p. 5

    Google Scholar 

  11. Alderson, P.O., Sumner, H.W., Siegel, B.A.: The single palpable thyroid nodule. Cancer37:258, 1976

    Google Scholar 

  12. Shunaoko, K., Sokal, J.E.: Differentiation of benign and malignant thyroid nodules by scintiscan. Arch. Intern. Med.144:36, 1964

    Google Scholar 

  13. Psarras, A., Papadopoulos, S.N., Livadas, D., Pharmakiolis, A.D., Koutras, D.A.: The single thyroid nodule. Br. J. Surg.59:545, 1972

    Google Scholar 

  14. Shambaugh, G.E., III, Quinn, J.L., Oyasu, R., Freinkel, N.: Disparate thyroid imaging combined studies with sodium pertechnetate99Tcm and radioactive iodine. J.A.M.A.228:866, 1974

    Google Scholar 

  15. O'Connor, M.K., Cullen, M.J., Malone, J.F.: A kinetic study of [I131] iodide and [99mTc] pertechnetate in thyroid cancer to explain a scan discrepancy: case report. J. Nucl. Med.18:796, 1977

    Google Scholar 

  16. Massin, J.P., Plauchon, C., Perez, R.: Comparison of99mTc-Pertechnetate and I131 in scanning of thyroid nodules. Clin. Nucl. Med.2:324, 1977

    Google Scholar 

  17. Ridgeway, E.C., Weintraub, B.D., Cevallos, J.L., Rock, M.C., Maloot, F.: Suppression of TSH secretion in the patient with a hyperfunctioning thyroid nodule. J. Clin. Invest.52:2783, 1973

    Google Scholar 

  18. Lahey, F.H.: Preoperative diagnosis of carcinoma of the thyroid in surgery of the thyroid. Surg. Clin. North Am.33:781, 1953

    Google Scholar 

  19. Cowan, R.J.: Thyroid imaging with radionuclides. In Continuing Education Lectures. A Review of Nuclear Medicine. Part I, Proceedings of the South-eastern Chapter, Society of Nuclear Medicine, Atlanta, Georgia, 1976, pp. 2.1–2.15

    Google Scholar 

  20. Miskin, M., Rosen, I.B., Walfish, P.G.: B-mode ultrasonography in the assessment of thyroid gland lesions. Ann. Intern. Med.79:505, 1973

    Google Scholar 

  21. Ma, M., Ong, G.B.: Cystic thyroid nodules. Br. J. Surg.62:205, 1975

    Google Scholar 

  22. Thijs, L.G., Wierner, J.D.: Ultrasonic examination of the thyroid gland, possibilities and limitations. Am. J. Med.60:96, 1976

    Google Scholar 

  23. Miller, J.M., Zafar, S.U., Karo, J.J.: The cystic thyroid nodule. Radiology110:257, 1974

    Google Scholar 

  24. Crocker, E.F., McLoughlin, A.F., Kossof, G.: The grey scale echographic appearance of thyroid malignancy. J.C.U.2:305, 1974

    Google Scholar 

  25. Taylor, K.J.W., Carpenter, D.A., Barrett, J.: Grey-scale ultrasonography in the diagnosis of thyroid swelling. J.C.U.2:327, 1974

    Google Scholar 

  26. Chilcote, W.S.: Grey scale ultrasonography of the thyroid. Radiology120:381, 1976

    Google Scholar 

  27. Kaplan, W.D., Holman, B.L., Seleukow, H.A., Davis, M.A., Holmes, R.A., Isitman, A.T., Chandler, H.L.:67Ga-Citrate and the nonfunctioning thyroid nodule. J. Nucl. Med.15:424, 1974

    Google Scholar 

  28. Fukuchi, M., Tachibana, K., Kuwata, K., Nishikawa, A., Hyodo, K., Okamoto, E., Nagai, K.: Thallium-201 imaging in a thyroid carcinoma—appearance of a lymph-node metastasis. J. Nucl. Med.19:195, 1978

    Google Scholar 

  29. Koutras, D.A., Pandos, P.G., Sfontouris, J., Koukoulommati-Spentza, A., Psarras, A., Malamos, B.: Thyroid scanning with Gallium-67 and Cesium-131. J. Nucl. Med.17:268, 1976

    Google Scholar 

  30. Weinstein, M.B., Ashkar, F.S., Caron, C.D.:75Se Selenomethionine as a scanning agent for the differential diagnosis of the cold thyroid nodule. Semin. Nucl. Med.1:390, 1971

    Google Scholar 

  31. Mori, T., Hamamoto, K., Onayama, Y., Torizuka, K.: Tumour imaging after administration of99mTc labelled bleomycin. J. Nucl. Med.16:414, 1975

    Google Scholar 

  32. Scheider, A.B., Favus, M.J., Stachura, M.E., Arnold, J.E., Ryo, U.Y., Pinsky, S., Colman, M., Arnold, M.J., Frohman, L.A.: Plasma thyroglobulin in detecting thyroid carcinoma after childhood head and neck irradiation. Ann. Intern. Med.86:29, 1977

    Google Scholar 

  33. Patton, J.A., Hollifield, J.N., Brill, A.B., Lee, G.S., Patton, D.D.: Differentiation between malignant and benign solitary thyroid nodules by fluorescent scanning. J. Nucl. Med.17:17, 1976

    Google Scholar 

  34. Tadros, T.G., Maisey, M.N., Tang Fui, S.C.N., Turner, P.C.: The iodine concentration in benign and malignant thyroid nodules using x-ray fluorescence. Accepted for publication by B.J. Surg.

  35. Pochin, E.E.: Radioiodine therapy of thyroid cancer. Semin. Nucl. Med.1:503, 1971

    Google Scholar 

  36. Edmonds, C.J., Smith, T., Barnaby, C.F.: Follow-up of thyroid carcinoma by whole body counting. B.J.R.43:868, 1970

    Google Scholar 

  37. Edmonds, C.J., Hayes, S., Kermode, J.C., Thompson, B.D.: Measurement of serum TSH and thyroid hormones in the management of treatment of thyroid carcinoma with radioiodine. B.J.R.50:799, 1977

    Google Scholar 

  38. Stahl, T.J., Shapiro, B.: Use of human thyrotropin radioimmunoassay in the management of patients with thyroid carcinoma. J. Nucl. Med.14:900, 1973

    Google Scholar 

  39. Bekerman, C., Gottschalk, A., Hoffer, P.B.: Optimal time for131I total body imaging to detect metastatic thyroid carcinoma, abstracted. J. Nucl. Med.15:477, 1974

    Google Scholar 

  40. Thomas, S.R., Maxon, H.R., Kereiakes, J.G., Saenger, E.L.: Quantitative external counting techniques enabling improved diagnostic and therapeutic decisions in patients with well differentiated thyroid cancer. Radiology122:731, 1977

    Google Scholar 

  41. Hershman, J.M., Edwards, C.L.: Serum thyrotropin (TSH) levels after thyroid ablation compared with TSH levels after exogenous bovine TSH: implications for I131 treatment of thyroid carcinoma. J. Clin. Endocrinol. Metab.34:814, 1972

    Google Scholar 

  42. Krishnamurthy, G.T., Blahd, W.H.: Diagnostic and therapeutic implications of long-term radioisotope scanning in the management of thyroid cancer. J. Nucl. Med.13:924, 1972

    Google Scholar 

  43. Hamburger, J.I.: Diuretic augmentation of131I uptake in inoperable thyroid cancer. N. Engl. J. Med.280:1091, 1969

    Google Scholar 

  44. Rall, J.E., Miller, W.N., Foster, C.G., Peacock, W.C., Rawson, R.W.: The use of thiouracil in the treatment of metastatic carcinoma of the thyroid with radioiodine. J. Clin. Endocrinol. Metab.11:1273, 1951

    Google Scholar 

  45. Preisman, R.A., Halpern, S.: Detection of metastatic thyroid carcinoma after the administration of a therapeutic dose of131I-Iodine. Eur. J. Nucl. Med.3:69, 1978

    Google Scholar 

  46. Henk, J.M., Kirkman, S., Owen, G.M.: Whole body scanning and I131 therapy in the management of thyroid carcinoma. B.J.R.45:369, 1972

    Google Scholar 

  47. Bonte, F.J., McConnell, R.W.: Pulmonary metastases from differentiated thyroid carcinoma demonstrable only by nuclear imaging. Radiology107:585, 1973

    Google Scholar 

  48. Turner, J.E., Weir, G.J., Jr.: Pulmonary metastases from thyroid carcinoma detectable only by131I scan. Treatment and response. J. Nucl. Med.13:852, 1972

    Google Scholar 

  49. Woolfenden, J.M., Waxman, A.D., Wolfstein, R.S., Siemsen, J.K.: Scintigraphic evaluation of liver metastases from thyroid carcinoma. J. Nucl. Med.16:669, 1975

    Google Scholar 

  50. Attie, J.N.: Feasibility of total thyroidectomy in the treatment of thyroid carcinoma. Postoperative radioactive iodine evaluation of 140 cases. Am. J. Surg.138:555, 1979

    Google Scholar 

  51. Gardet, P., Parmentier, C., Gerard-Marchant, R., L'Heritier, C., Caillou, B., Cukersztein, W., Tubiana, M.: Differentiated cancers of the thyroid: course after treatment with special reference to frequency and chronology of the first relapse for 470 treated patients. Ann. Radiol. (Paris)20:831, 1977

    Google Scholar 

  52. Van Herle, A.J., Uller, R.P.: Elevated serum thyroglobulin. A marker for metastases in differentiated thyroid carcinoma. J. Clin. Invest.56:272, 1975

    Google Scholar 

  53. Lo Gerfo, P., Stillman, T., Colacchio, D., Feind, C.: Serum thyroglobulin and recurrent thyroid cancer. Lancet1:881, 1977

    Google Scholar 

  54. Ng Tang Fui, S.C., Hoffenberg, R., Black, E.G., Maisey, M.N.: Serum thyroglobulin concentration and whole-body radioiodine scan in the follow-up of differentiated thyroid cancer after thyroid ablation. Br. Med. J.2:298, 1979

    Google Scholar 

  55. Hoffman, D.P., Surks, M.I., Oppenheimer, J.H., Weitzman, E.D.: Response to thyrotrophic releasing hormone: an objective criteria for the adequacy of thyrotrophic suppression therapy. J. Clin. Endocrinol. Metab.44:892, 1977

    Google Scholar 

  56. Lombery, B.A.: Choosing thyroxine dose after treatment of thyroid cancer. Lancet11:1280, 1977

    Google Scholar 

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  1. Department of Nuclear Medicine, Guy's Hospital, St Thomas Street, SE1 9RT, London, England

    M. N. Maisey M.D., F.R.C.P.

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Maisey, M.N. Methods of investigation in the diagnosis and management of thyroid carcinoma. World J. Surg. 5, 49–57 (1981). https://doi.org/10.1007/BF01657834

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