Summary
Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could be detected in c-src protein and c-src kinase activity levels between fbroblasts from healthy controls and affected individuals. Thus, impairment of c-src function as an etiological factor in human osteopetrosis appears unlikely in the individuals investigated.
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Meyerson, G., Dahl, N. & Påhlman, S. Malignant Osteopetrosis: c-src kinase is not reduced in fibroblasts. Calcif Tissue Int 53, 69–70 (1993). https://doi.org/10.1007/BF01352018
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DOI: https://doi.org/10.1007/BF01352018