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Demonstration of a tumour and transplantation antigen in hamster tumours induced by an avian adenovirus (CELO)

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Summary

Tumour transplant immunity studies in hamsters demonstrated a transplantation antigen in CELO tumour cells. The transplant immunity was apparently virus specific since hamsters immunized with CELO virus did not reject transplants of SV40 induced hamster tumour cells.

Immunofluorescence studies indicated the presence of a CELO virus tumour antigen in serially cultured tissue culture cells derived from a CELO induced hamster tumour. The antigen was located in the cell nuclei, and could not be detected in the cytoplasm. CELO virus has several properties which may make it a useful model virus for studies of viral oncogenesis.

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Author notes

  1. G. C. Schild

    Present address: Division of Bacteriology and Virology, National Institute for Medical Research, Mill Hill, London N. W. 7, England

Authors and Affiliations

  1. Lodge Moor Hospital, University of Sheffield Virus Research Laboratory, Sheffield, England

    G. C. Schild, J. S. Oxford & C. W. Potter

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  1. G. C. Schild
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  2. J. S. Oxford
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  3. C. W. Potter
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Schild, G.C., Oxford, J.S. & Potter, C.W. Demonstration of a tumour and transplantation antigen in hamster tumours induced by an avian adenovirus (CELO). Archiv f Virusforschung 29, 25–31 (1970). https://doi.org/10.1007/BF01253876

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  • DOI: https://doi.org/10.1007/BF01253876

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