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Genetic alterations of brain tumors

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References

  1. Rouleau GA, Seizinger BR, Wertelecki W, Haines JL, Superneau DW, Martuza RL, Gusella JF: Flanking markers bracket the neurofibromatosis type 2 (NF 2) gene on chromosome 22. Am J Hum Genet 46: 323–328, 1990

    Google Scholar 

  2. Seizinger BR, Martuza RL, Gusella JF: Loss of genes on chromosome 22 in tumorigenesis of human acoustic neuroma. Nature 322: 644–647, 1986

    Google Scholar 

  3. Seizinger BR, Rouleau G, Ozelius LJ, Lane AH, George-Hyslop PS, Huson S, Gusella JF, Martuza RL: Common pathogenetic mechanism for three tumor types in bilateral acoustic neurofibromatosis. Science 236: 317–319, 1987

    Google Scholar 

  4. Daumas-Duport C, Scheithauer B, O'Fallon J, Kelly P: Grading of astrocytomas. A simple and reproducible method. Cancer 62: 2152–2165, 1988

    Google Scholar 

  5. Marshall CJ: Tumor suppressor genes. Cell 64: 313–326, 1991

    Google Scholar 

  6. Bigner SH, Burger PC, Wong AJ, Werner MH, Hamilton SR, Muhlbaier LH, Vogelstein B, Bigner DD: Gene amplification in malignant human gliomas: Clinical and histopathologic aspects. J Neuropath Exp Neurol 47: 191–205, 1988

    Google Scholar 

  7. El-Azouzi M, Chung RY, Farmer GE, Martuza RL, Black PM, Rouleau GA, Hettlich C, Hedley-Whyte ET, Zervas NT, Pangopoulos K, Nakamura Y, Gusella JF, Seizinger BR: Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas. Proc Natl Acad Sci USA 86: 7186–7190, 1989

    Google Scholar 

  8. Seizinger BR: Antioncogenes and the development of tumors in the human nervous system. Cancer 70 (Suppl): 1782–1787, 1992

    Google Scholar 

  9. Harris CC, Hollstein M: Clinical implications of the p53 tumor-suppressor gene. New Engl J Med 329: 1318–1327, 1993

    Google Scholar 

  10. Olopade OI, Rowley JD: Human chromosome maps: Relevance to identifying genetic changes in tumors of the nervous system. In: Levine AJ, Schmidek HH (eds) Molecular genetics of nervous sytem tumors. Wiley-Liss, New York, Chichester 179–194, 1993

    Google Scholar 

  11. Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM: Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 244: 1121–1124, 1984

    Google Scholar 

  12. Rouah E, Wilson DR, Armstrong DL, Darlington GJ: Nmyc amplification and neuronal differentiation in human primitive neuroectodermal tumors of the central nervous system. Cancer Rev 50: 2987–2990, 1989

    Google Scholar 

  13. Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyano M, Parry DM, Eldrige R, Kley N, Menon AG, Pulaski K, Hasse V, Ambrose CM, Munroe D, Bove C, Haines JL, Martuza RL, MacDonald ME, Seizinger BR, Short MP, Buckler AJ, Gusella JF: A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72: 791–800, 1993

    Google Scholar 

  14. Mashiyama S, Murakami Y, Yoshimoto T, Sekiya T, Hayashi K: Detection of p53 gene mutations in human brain tumors by single strand conformation analysis of polymerase chain reaction products. Oncogene 6: 1313–1318, 1991

    Google Scholar 

  15. Lane DP: p53, the guardian of the genome. Nature 358: 15–16, 1992

    Google Scholar 

  16. Sidransky D, Mikkelsen T, Schwechheimer K, Rosenblum ML, Cavanee W, Vogelstein B: Clonal expansion of p53 mutant cells is associated with brain tumor progression. Nature 355: 846–847, 1992

    Google Scholar 

  17. Kyritsis AP, Bondy ML, Xiaou M, Berman EL, Cunningham JE, Lees PS, Levin VA, Saya H: Germline p53 gene mutations in subset of glioma patients. J Natl Cancer Inst 86: 344–349, 1994

    Google Scholar 

  18. v. Deimling A, Louis DN, Schramm J, Wiestler OD: Astrocytic gliomas: Characterization on a molecular genetic basis. In: Wiestler OD, Schlegel U, Schramm J (eds) Molecular neuro-oncology and its impact on the clinical management of brain tumors. Recent results in cancer research, Vol. 135. Springer, Berlin, Heidelberg, New York 33–42, 1994

    Google Scholar 

  19. v. Deimling A, v. Ammon K, Schoenfeld D, Wiestler OD, Seizinger BR, Louis DN: Subsets of glioblastoma multiforme defined by molecular genetic analysis. Brain Path 3: 19–26, 1993

    Google Scholar 

  20. Scherer HJ: Cerebral astrocytomas and their derivatives. Am J Cancer 40: 159–198, 1940

    Google Scholar 

  21. Kimmel DW, Shapiro JR, Shapiro WR:In vitro drug sensitivity testing in human gliomas. J Neurosurg 66: 161–171, 1987

    Google Scholar 

  22. Shapiro JR, Pu PY, Mohamed AN, Galicich JH, Ebrahim SAD, Shapiro WR: Chromosome number and carmustine sensitivity in human gliomas. Cancer 71: 4007–4021, 1993

    Google Scholar 

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von Ammon, K., Roelcke, U. Genetic alterations of brain tumors. J Neuro-Oncol 22, 245–248 (1994). https://doi.org/10.1007/BF01052928

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