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Tumor- und arzneimittel-induzierte cutane axon-dystrophie

Elektronenmikroskopischer nachweis multipler lamellärer Körper

Tumor- and drug-induced cutaneous axonal dystrophy

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Summary

A marked cutaneous axonal dystrophy has been observed electronmicroscopically for the first time in the skin of three patients: (a) lesion of pityriasis lichenoides chronica in a patient with bronchogenic carcinoma, (b) non involved skin of a patient with malignant melanoma and (c) non involved skin of a patient with gout and retinal damage after prolonged use of chloroquine. The affected myelinated and non myelinated axons showed distinet alterations of mitochondria and multiple osmiophilic lamellated bodies (LK). These changes were interpreted as a (poly-)neuropathy, due to the influence of toxie systemic agents, such as malignant tumor and abuse of drugs. Chloroquine is known to induce neural damage. Moreover, some other compounds (ergotamine. ethaverine, analgetic preparations) may also be responsible for the drug-induced axonal dystrophy described in this study.

Zusammenfassung

An den Hautnerven von drei Kranken (Bronchial-Carcinom, metastasierendes malignes Melanom, Gicht mit chronischem Resochin®-Schaden) wurde erstmalig eine cutane axonale Dystrophie beobachtet, die mit Mitochondrien-Alterationen und dem Auftreten multipler osmiophiler Einschlüsse (lamelläre Körper, LK) einhergeht. Diese Veränderung wurde als eine nucleo-distale (Poly-)Neuropathie interpretiert. hervorgerufen durch den Einfluß systemischer Noxen. Als solche wurden bei den hier beschriebenen Fällen metastasierende Geschwülste (Bronchial-Carcinom und malignes melanom) sowie ein chronischer Mißbrauch von Medikamenten, insbesondere von Resochin, angesehen.

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  1. Universitäts-Hautklinik, Köln, BRD

    Ulf Runne & Constantin E. Orfanos

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  1. Ulf Runne
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  2. Constantin E. Orfanos
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Herrn Prof. Schneider, Tübingen, zum 65. Geburtstag gewidmet.

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Runne, U., Orfanos, C.E. Tumor- und arzneimittel-induzierte cutane axon-dystrophie. Arch. Derm. Res. 254, 55–66 (1975). https://doi.org/10.1007/BF00561535

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  • DOI: https://doi.org/10.1007/BF00561535

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