Summary
The aim of this study was to compare the time course of 14C-steroid excretion following administration of 14C-cholesterol in normal and CS2intoxicated rats. The excretion of steroid with the feces was evaluated in the normal and CS2 intoxicated rats at the end of 7 month exposure to CS2. The results of the experiment indicated that in rats exposed to CS2 excretion of 14C-steroid is lower. It was due to a reduced excretion of 14C-bile acid fraction while at the same time the share of sterol α + β rose. On the basis of our former results which excluded the influence of CS2 on absorption of cholesterol and indicated its effect on cholesterol synthesis it was revealed in this experiment that intoxication with CS2 also inhibits cholesterol degradation. Disturbances of both processes can be essential for accumulation of cholesterol in blood of animals intoxicated with CS2.
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This investigation has been carried out under the Polish-American agreement No. 05-008-2 with the Occupational Health Program, U.S. Public Health Service
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Wrońska-Nofer, T. Effect of carbon disulphide intoxication on fecal excretion of end products of cholesterol metabolism. Int. Arch Occup Environ Heath 40, 261–265 (1977). https://doi.org/10.1007/BF00381414
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DOI: https://doi.org/10.1007/BF00381414