Summary
To compare the thermoregulatory responses of normal subjects and patients with atopic dermatitis, the effect of exercise under moderate heat stress was examined in two groups of subjects. Each group of eight subjects (controls or clinical atopics) underwent a 90-min experiment after being equipped with probes for measurement of core and skin temperatures, heart rate and overall and local sweating rates. Sweat surface tension was determined from sweat collection made at the end of the session. The experimental procedure was as follows: 30 min rest at thermoneutrality, 30 min cycling at 90 W at 36‡C, followed by 30 min recovery sitting at rest at 36‡C on the cycloergometer. None of the registered variables differed significantly between the normal and atopic subjects except for variations in mean skin temperature, core-to-skin temperature difference and sweat surface tension. Since local sweating on non-affected skin under a controlled thermal clamp was not altered by atopy, it can be concluded that the thermoregulatory modifications under heat stress is of vasomotor origin, the benefit of which, in terms of heat dissipation capacity, remains uncertain. There may be alterations in the constituents of sweat, but not in its excretion rate. Local, rather than central, factors are probably involved in this qualitative change, which remains to be investigated.
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References
Bachmann-Andersen L, Thestrup-Petersen K (1987) Sweat pore density on the fingertips of atopic patients. Br J Dermatol 117: 225–230
Candas V (1987) Adaptation to extreme environments. Thermophysiological changes in man during humid heat acclimation. In: Dejours P (ed) Comparative physiology of environmental adaptation, vol 2. Eighth ESCP Conference, Strasbourg, 1986. Kager, Basel, pp 76–93
Champion RH (1963) Abnormal vascular reactions in atopic eczema. Br J Dermatol 75: 12–15
Fujita M, Aoki T (1975) Sweat suppression in patients with atopic dermatitis and infantile xerotic eczema. Jpn J Dermatol 85: 291–294
Greene RM, Winkelman RK, Opfer-Gehrkring TL, Low PA (1989) Sweating patterns in atopic dermatitis patients. Arch Dermatol Res 281: 373–376
Grosshans E, Woehl M (1982) Troubles vasomoteurs, sudoraux et sébacés de l'eczéma constitutionnel. Ann Dermatol Venereol (Paris) 109: 151–162
Grosshans E, Juillard J, Libert JP, Candas V, Vogt JJ (1980) Physiopathology of sweating response in individuals with eccrine glands of the rare reticulated clear cell type. J Invest Dermatol 74: 455–456
Hanifin JM, Rajka G (1980) Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl 92: 44–47
Hardy JD, DuBois EF (1938) Basal metabolism, radiation, convection and evaporation at temperatures of 22–35‡C. J. Nutr 15: 477–496
Heyer G, Schönberger A, Hornstein OP (1988) Störungen der Thermoregulation auf externe KÄlte- und WÄrmereize bei Patienten mit atopischem Ekzem. Hautarzt 39: 18–22
Kiistala R (1982) Stimulated local sweating response in atopic dermatitis (abstract). XVI Congressus Internationalis Dermatologiae, Tokyo, May 1982. p 320
Kocsard E, Ofner F, Broe GA (1973) Paradox temperature response in atopic dermatitis. Dermatologica 146: 8–14
Lobitz WC, Campbell CJ (1953) Physiologic studies in atopic dermatitis (disseminated neurodermatitis). I. The local cutaneous response to intradermally injected acetylcholine and epinephrine. Arch Dermatol Syphilol 67: 575–589
Mali JWH (1971) Skin lesions of the atopic syndrome. The sweat gland as a mucous gland. Dermatologists Nijmegen, March 1970. Dermatologica 142: 103–104
Manku MS, Horrobin DF, Morse NL, Wright S, Burton JL (1984) Essential fatty acids in the plasma phospholipids of patients with atopic eczema. Br J Dermatol 110: 643–648
Murphy GM, Smith SE, Smith SA, Greaves MW (1984) Autonomic function in cholinergic urticaria and atopic eczema. Br J Dermatol 110: 581–586
Ogawa T, Asayama M (1986) Quantitative analysis of the local effect of skin temperature on sweating. Jpn J Physiol 36: 417–422
Rovensky J, Saxl O (1964) Differences in the dynamics of sweat secretion in atopic children. J Invest Dermatol 43: 171–176
Sulzberger MB, Herrmann F, Zak FG (1947) Studies of sweating. I. Preliminary report with particular emphasis on a sweat retention syndrome. J Invest Dermatol 9: 221–242
Szentivanyi A (1968) The beta-adrenergic theory of the atopic abnormality in bronchial asthma. J Allergy 42: 203–232
Thune P, Kocsis M (1975) Effects of adrenergic stimulating and blocking agents on the eccrine sweat secretion in atopic dermatitis and psoriasis. Arch Dermatol Res 253: 97–103
Warndorff JA (1970) The response of the sweat gland to acetylcholine in atopic subjects. Br J Dermatol 83: 306–311
Werner Y, Lindberg M (1985) Transepidermal water loss in dry and clinically normal skin in patients with atopic dermatitis. Acta Derm Venereol (Stockh) 65: 102–105
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Bothorel, B., Heller, A., Grosshans, E. et al. Thermal and sweating responses in normal and atopic subjects under internal and moderate external heat stress. Arch Dermatol Res 284, 135–140 (1992). https://doi.org/10.1007/BF00372705
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DOI: https://doi.org/10.1007/BF00372705