Abstract
It is very unusual for a carcinoma of the breast to coexist with a phyllodes tumor, or for a carcinoma to arise within a fibroadenoma. We present herein an extremely rare case of lobular carcinoma in situ arising in a fibroadenoma, associated with a malignant phyllodes tumor in the opposite breast. A 49-year-old woman was admitted to our hospital with a large mass in the right breast and a small mass in the left breast. Microscopic examination of biopsy materials revealed a malignant phyllodes tumor in the right breast and a fibroadenoma in the left breast, for which a right standard radical mastectomy and left lumpectomy were performed. Microscopic findings of the material excised from the left breast showed the presence of multiple lobular carcinoma in situ within the tumor mass of the fibroadenoma. However, histological examination did not detect any metastasis to the bilateral axillary lymph nodes. To our knowledge this is the only such case ever to be reported in Japan.
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References
Dyer NH, Bridger JE, Taylor RS (1966) Cystosarcoma phyllodes. Br J Surg 53:450–455
Lester J, Stout AP (1954) Cystosarcoma phyllodes. Cancer 7:335–353
Treves N, Sunderland DA (1951) Cystosarcoma phyllodes of the breast: A malignant and a benign tumor. A clinicopathological study of 77 cases. Cancer 4:1286–1332
Al-Jurf A, Hawk WA, Crile G Jr (1978) Cystosarcoma phyllodes. Surg Gynecol Obstet 146:358–364
Hart WR, Bauer RC, Oberman HA (1978) Cystosarcoma phyllodes. A clinicopathologic study of 26 hypercellular periductal stromal tumors of the breast. Am J Clin Pathol 70:211–216
Hajdu SI, Espinosa MH, Robbins GF (1976) Recurrent cystosarcoma phyllodes: A clinicopathologic study of 32 cases. Cancer 38:1402–1406
Blichert-Toft M, Hansen JPH, Hansen OH, Schiodt T (1975) Clinical course of cystosarcoma phyllodes related to histologic appearance. Surg Gynecol Obstet 140:929–932
Rosen PP, Urban JA (1975) Coexistent mammary carcinoma and cystosarcoma phyllodes. Breast 1:9–15
Richards WG, Way RW (1963) Co-existent cystosarcoma phyllodes and scirrhous adenocarcinoma of the breast. Wis Med J 62:425–428
McCormick MV, Pillary SP (1977) Malignant cystosarcoma phyllodes associated with scirrhous carcinoma of the breast. S Afr Med J 52:893–894
Lee BJ, Pack GT (1931) Giant intracanalicular fibro-adenomyxoma of the breast. The so-called cystosarcoma phyllodes mammae of Johannes Muller. Am J Cancer 15:2583–2609
Hafner CD, Mezger E, Wylie JH Jr (1962) Cystosarcoma phyllodes of the breast. Surg Gynecol Obstet 1:29–34
Brown, MJ (1960) A rare complication of female breast tumors. J Iowa Med Soc 12:709–713
Stone-Tolin K, Pollak EW, Dorzab W, Printz J (1982) Recurring cystosarcoma phyllodes associated with breast carcinoma. South Med J 75:881–884
Norris HJ, Taylor HB (1967) Relationships of histologic features to behavior of cystosarcoma phyllodes. Analysis of 94 cases. Cancer 20:2090–2099
Ozzello L, Gump FE (1985) The management of patients with carcinomas in fibroadenomatous tumors of the breast. Surg Gynecol Obstet 160:99–104
Fondo EY, Rosen PP, Fracchia AA, Urban JA (1979) The problem of carcinoma developing in a fibroadenoma: Recent experience at Memorial Hospital. Cancer 43:563–567
McDivitt RW, Stewart FW, Farrow JH (1967) Breast carcinoma arising in solitary fibroadenomas. Surg Gynecol Obstet 125:572–576
Pick PW, Iossifides IA (1984) Occurrence of breast carcinoma within a fibroadenoma. Arch Pathol Lab Med 108:590–594
Ashikari R, Huvos AG, Urban JA, Robbins GF (1973) Infiltrating lobular carcinoma of the breast. Cancer 31:110–116
Fisher ER, Gregorio RM, Fisher B (1975) The pathology of invasive breast cancer. Cancer 36:1–85
Martinez V, Azzopardi JG (1979) Invasive lobular carcinoma of the breast: Incidence and variants. Histopathology 3:467–488
Newman W (1966) Lobular carcinoma of the female breast. Report of 73 cases. Ann Surg 164:305–314
Hutter RVP (1984) The management of patients with lobular carcinoma in situ of the breast. Cancer 53:798–802
Petrek JA (1991) Cystosarcoma phyllodes. In: Harris JR, Hellman S, Henderson IC, Kinne DW (eds) Breast disease, 2nd edn. Lippincott, Philadelphia, pp 791–797
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Morimoto, T., Tanaka, T., Komaki, K. et al. The coexistence of lobular carcinoma in a fibroadenoma with a malignant phyllodes tumor in the opposite breast: Report of a case. Surg Today 23, 656–660 (1993). https://doi.org/10.1007/BF00311918
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DOI: https://doi.org/10.1007/BF00311918