Summary
The karyotype of leukemic cells was studied in 88 acute nonlymphocytic leukemia (ANLL) patients. Chromosome abnormalities were discovered in 78.4% of all patients and in 72.5% of the 69 patients studied before treatment. Characteristic abnormalities: translocations 8;21, 15;17, 9;22 or 6;9, rearrangements of 11q, gain of chromosomes 8 or 21, and loss or deletion of chromosomes 5 or 7 were detected in 56 of 69 patients with abnormal karyotypes. Translocation 8;21 was revealed in 27 patients; 20 of them had M2 FAB-form, four had M1, and three had M4. In patients with t(8;21) the incidence of complete remission was higher and the duration of first remission and survival longer than in patients with other abnormalities or with a normal karyotype.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Abe R, Sandberg AA (1984) Significance of abnormalities involving chromosomal segment 11q22-25 in acute leukemia. Cancer Genet Cytogenet 13:121–127
Arthur DC, Bloomfield CD (1984) Banded chromosome analysis in patients with treatment-associated acute nonlymphocytic leukemia. Cancer Genet Cytogenet 12:189–199
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) French-American-British (FAB) Co-operative group. Proposals for the classification of the acute leukemias. Br J Haematol 33:451–458
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1980) A variant form of hypergranular promyelocytic leukemia (M3). Br J Haematol 44:169–170
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1982) The French-American-British (FAB) Cooperative Group. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51:189–199
Berger R, Bernheim A, Daniel MT, Valensi F, Sigaux F, Flandrin G (1982a) Cytologic characterization and significance of normal karyotypes in t(8;21) acute myeloblastic leukemia. Blood 59:171–178
Berger R, Bernheim A, Sigaux F, Daniel MT, Valensi F, Flandrin G (1982b) Acute monocytic leukemia chromosome studies. Leuk Res 6:17–26
de la Chapelle A, Knuutila S, Elonen E, Vuopio P (1980) Chromosomal abnormalities in acute promyelocytic leukemia. Scand J Haematol 26:57–60
First International Workshop on Chromosomes in leukemia (1978) Chromosomes in acute non-lymphocytic leukemia. Br J Haematol 39:311–316
fleischman EW, Prigogina EL, Iljinskaja GW, Konstantinova LN, Puchkove GP, Volkova MA, Frenkel MA, Balakirev SA (1983) Chromosomal rearrangements with a common breakpoint at 6p23 in 5 cases of myeloid leukemia. Hum Genet 64:254–256
Fourth International Workshop on Chromosomes in Leukemia 1982 (1984) Cancer Genet Cytogenet 11:249–350
Hagemeijer A, Lövenberg B, Abels J (1982a) Analysis of the breakpoints in translocation (15;17) observed in four patients with acute promyelocytic leukemia (1982). Hum Genet 61:223–227
Hagemeijer A, Hählen K, Sizoo W, Abels J (1982b) Translocation (9;11)(p21;q23) in three cases of acute monoblastic leukemia. Cancer Genet Cytogenet 5:95–106
Hossfeld DK, Higi M, Köhler S, Miller A, Zschaber R (1980) A subtype of the prototypic karyotype in acute myeloid leukemia t(8;21)(q22;q22), del(9)(q13;q23). Blut 40:27–32
Hustinx TWJ, Burghouts JTM, Scherers JMJC, Smits APT (1980) A case of AMMOL with 8/21 translocation and loss of the Y as probably secondary events. Cancer 45:285–288
ISCN (1978) An international system for human cytogenetic nomenclature. Cytogenet Cell Genet 21:309–404
Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457–481
Kondo K, Sasaki M (1982) Further cytogenetic studies on acute promyelocytic leukemia. Cancer Genet Cytogenet 6:39–46
Mecucci C, Vermaelen K, Kulling G, Michaux JL, Noens L, van Hove W, Tricot G, Louwagie A, van den Berghe H (1984) Interstitial 9q deletions in hematologic malignancies. Cancer Genet Cytogenet 12:309–319
Mitelman F, Nilsson PG, Brandt L, Alimena G, Gastaldi R, Dallapiccola B (1981) Chromosome pattern, occupation, and clinical features in patients with acute nonlymphocytic leukemia. Cancer Genet Cytogenet 4:197–214
Nagasaka M, Maeda S, Maeda H, Chen H.-L, Kita K, Mabuchi O, Misu H, Matsuo T, Sugiyama T (1983) Four cases of t(4;11) acute leukemia and its myelomonocytic nature in infants. Blood 61: 1174–1181
Neame PB, Soamboonsrup P, Browman G, Barr RD, Saced N, Chan B, Pai M, Berger A, Wilson WE, Walker TR, Mc-Bride JA (1985) Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemia. Blood 65:142–148
Ohyashiki K, Oshimura M, Uchida H, Nomoto S, Sakai N, Tonomura A, Ito H (1985) Cytogenetic and ultrastructural studies on ten patients with acute promyelocytic leukemia including one case with a complex translocation. Cancer Genet Cytogenet 14:247–255
Peto R, Pike MC, Armitage P (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1–39
Prigogina EL, Fleischman EW, Puchkova GP, Kulagina OE, Majakova SA, Balakirev SA, Frenkel MA, Khvatova NV, Peterson IS (1979) Chromosomes in acute leukemia. Hum Genet 53:5–16
Rowley JD, Testa JR (1982) Chromosome abnormalities in malignant hematologic diseases. Adv Cancer Res 36:103–148
Rowley JD, Golomb HM, Vardiman JW (1981) Nonrandom chromosome abnormalities in acute leukemia and dysmyelopoietic syndromes in patients with previously treated malignant disease. Blood 58:759–767
Sandberg AA (1979) The chromosomes in human cancer and leukemia. Elsevier/North-Holland, Amsterdam New York
Second International Workshop on chromosomes in Leukemia 1979 (1980) Cancer Genet Cytogenet 2:89–113
Strong RC, Korsmeyer SJ, Parkin JL, Arthur DC, Kersey JH (1985) Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B-lineage and monocytic characteristics. Blood 65:21–31
Swirsky DM, Li YS, Matthews JG, Flemans RJ, Rees RJ, Hayhoe FGJ (1984) 8,21 Translocation in acute granulocytic leukemia: cytological, cytochemical and clinical features. Br J Haematol 56:199–213
Teerenhovi L, Borgstrom GH, Mitelmann F, Brand L, Vuopio P, Timonen T, Almquist A, de la Chapelle A (1978) Uneven geographical distribution of 15; 17 translocation in acute promyelocytic leukaemia. Lancet II:797
Testa JR, Oguma N, Misawa S, Vernik PH (1983) Chromosome abnormalities in acute leukemia: a higher incidence than previously assumed. Cancer Genet Cytogenet 9:305–306
Tricot G, Broeckaert van Orshoven A, Casteels van Daele M, van den Berghe H (1981) 8/21 Translocation in acute myeloid leukemia. Scand J Haematol 26:168–176
van den Berghe H, David G, Broekhaert-van Orshoven A, Louwagie A, Verwilghen C, Casteels-van Daele M, Eggermont E, Eeckels R (1979) A new chromosome anomaly in acute lymphoblastic leukemia (ALL). Hum Genet 46:173–180
van Rhenen DJ, Verhulst JC, Huijgens PC, Langenhuijsen MMAC (1980) Maturation index: a contribution to quantification in the FAB classification of acute leukemia. Br J Haematol 46:581–586
Vermaelen K, Barbieri D, Michaux JL, Tricot G, Casteels van Daele M, Noens L, van Hove W, Drochmans A, Louwagie A, van den Berghe H (1983) Anomalies of the long arm of chromosome 11 in human myelo- and lymphoproliferative disorders. I. Acute non-lymphocytic leukemia. Cancer Genet Cytogenet 10:105–116
Whang-Peng J, Knutsen T, O'Donnel JF, Brenton HD (1979) Acute nonlymphocytic leukemia and acute myeloproliferative syndrome following radiation therapy for non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Cancer 44:1592–1600
WHO (1979) Handbook for reporting results of cancer treatment. WHO, Geneva
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Prigogina, E.L., Fleischman, E.W., Puchkova, G.P. et al. Chromosomes in acute nonlymphocytic leukemia. Hum Genet 73, 137–146 (1986). https://doi.org/10.1007/BF00291604
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00291604