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Organ-specific autoantibodies in non-organ-specific autoimmune diseases with special reference to rheumatoid arthritis

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Summary

Sera from 367 patients with rheumatoid arthritis (RA) and from 102 patients with other non-organspecific (NOS) autoimmune diseases were examined for the presence of organ-specific (OS) autoantibodies. The incidence of these OS autoantibodies was not increased in patients with NOS autoimmune diseases with the exception of thyroglobulin antibodies, which were significantly more frequent in RA (P<0.001) and in Sjögren's syndrome (P<0.05) patients than in normal controls. Investigation of 169 patients with OS autoimmune diseases did not reveal an increased prevalence of NOS autoantibodies. In RA patients, OS autoantibodies correlated with NOS autoantibodies (P<0.04) and with HLA-DR3 antigen (P<0.01).

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References

  1. Janin-Mercier A, Sauvezie B, Ristori JM, Betail G, Veyre A, Rampon S (1982) Histological and immunological study in patients with rheumatoid arthritis showing isolated abnormalities of salivary scintigraphy. J Clin Immunol 2:282–288

    Google Scholar 

  2. Carpenter CCJ, Solomon N, Silverberg SG, Bledsoe T, Northcutt RC, Klinenberg JR, Bennett IL, McGehee Harvey A (1964) Schmidt's syndrome (thyroid and adrenal insufficiency): a review of the literature and a report of 15 new cases including ten instances of co-existent diabetes mellitus. Medicine (Baltimore) 43:153–180

    Google Scholar 

  3. Ungar B, Stocks AE, Martin FIR, Whittingham S, Mackay IR (1968) Intrinsic factor antibody, parietal-cell antibody and latent pernicious anaemia in diabetes mellitus. Lancet II:415–418

    Google Scholar 

  4. Jarvinen KAJ (1960) A study of the interrelations of rheumatoid arthritis and diabetes mellitus. Ann Rheum Dis 19:226–230

    Google Scholar 

  5. Linos A, Worthington JW, Palumbo PJ, O'Fallon WM, Kurland LT (1980) Occurrence of Hashimoto's thyroiditis and diabetes mellitus in patients with rheumatoid arthritis. J Chron Dis 33:73–77

    Google Scholar 

  6. Oreskes I, Spiera H (1973) Diabetes and rheumatoid factor. Ann Rheum Dis 32:431–432

    Google Scholar 

  7. Thomas DJB, Young A, Gorsuch AN, Bottazzo GF, Cudworth AG (1983) Evidence for an association between rheumatoid arthritis and autoimmune endocrine disease. Ann Rheum Dis 42:297–300

    Google Scholar 

  8. Ropes MW, Bennett GA, Cobb S, Jacox R, Jessar RA (1958) Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis 9:175–176

    Google Scholar 

  9. Tan EM, Cohen AF, Fries JF, Masi AT, McShane DT, Nothfield NF, Schaller JG, Talal N, Winchester RT (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277

    Google Scholar 

  10. Moutsopoulos HM (1980) Clinical features of Sjögren's syndrome. Ann Intern Med 92:212–226

    Google Scholar 

  11. Scherbaum WA, Schumm F, Maisch B, Müller C, Fateh-Moghadam A, Flüchter SH, Seif FJ, Bottazzo GF, Berg PA (1983) Myasthenia gravis: overlap with ‘polyendocrine’ autoimmunity. Klin Wochenschr 61:509–515

    Google Scholar 

  12. Johnson GD, Holborow EJ (1963) Immunofluorescent test for rheumatoid factor in serum. Lancet II:1142–1143

    Google Scholar 

  13. Young BJJ, Mallya RK, Leslie RDG, Clark CJM, Hamblin TJ (1979) Antikeratin antibodies in rheumatoid arthritis. Br Med J 2:97–99

    Google Scholar 

  14. Sondag-Tschroots IRJM, Aaij C, Smit JW, Feltkamp TEW (1979) The antiperinuclear factor. I. The diagnostic significance of the antiperinuclear factor for rheumatoid arthritis. Ann Rheum Dis 38:248–251

    Google Scholar 

  15. Scherbaum WA, Mirakian R, Pujol-Borrell R, Dean BM, Bottazzo GF (1986) Immunocytochemistry in the study and diagnosis of organ-specific autoimmune disease. In: Polak JM, Van Noorden S (eds) Immunocytochemistry. Practical applications in pathology and biology. Wright PSG, Bristol

    Google Scholar 

  16. Terasaki PI, Bernoco D, Park MS, Osturk G, Iwaki Y (1978) Microdroplet testing for HLA-A, -B, -C and -DR antigens. Am J Clin Pathol 69:103–120

    Google Scholar 

  17. Fruman LS (1977) Diabetes mellitus, islet-cell antibodies and HLA-B8 in a patient with systemic lupus erythematosus. Am J Dis Child 131:1252–1254

    Google Scholar 

  18. Walker DJ, Griffith M, Griffith ID (1986) Occurrence of autoimmune diseases and autoantibodies in multicase rheumatoid arthritis families. Ann Rheum Dis 45:323–326

    Google Scholar 

  19. Mulhern LM, Masi AT, Shulman LE (1966) Hashimoto's disease: a search for associated disorders in 170 clinically detected cases. Lancet II:508–512

    Google Scholar 

  20. Ming Hang L, Theofilopoulos AN, Dixon FJ (1982) A spontaneous rheumatoid arthritis-like disease in MRL/1 mice. J Exp Med 155:1690–1701

    Google Scholar 

  21. Theofilopoulos AN, Dixon FJ (1985) Murine models of systemic lupus erythematosus. In: Dixon FJ (ed) Advances in immunology. Academic Press, Orlando

    Google Scholar 

  22. Kessler HS (1968) A laboratory model for Sjögren's syndrome. Am J Pathol 52:671–685

    Google Scholar 

  23. Yale J-F, Marliss EB (1984) Altered immunity and diabetes in the BB rat. Clin Exp Immunol 57:1–11

    Google Scholar 

  24. Khoury EL, Bottazzo GF, Pontes de Carvalho LC, Wick G, Roitt IM (1982) Predisposition to organ-specific autoimmunity in obese strain (OS) chickens: reactivity to thyroid, gastric, adrenal and pancreatic cytoplasmic antigens. Clin Exp Immunol 49:273–282

    Google Scholar 

  25. Haskard DO, Gul V, Morgan A, Kataaha P, Staines NA, Archer JR (1985) Human monoclonal antibodies from patients with rheumatoid arthritis: cross reactions against cellular constituents. Clin Exp Immunol 61:496–502

    Google Scholar 

  26. Shoenfeld Y, Rauch J, Massicotte H, Datta SK, Andre-Schwartz J, Stollar BD, Schwartz RS (1983) Polyspecificity of monoclonal lupus autoantibodies produced by human hybridomas. N Engl J Med 308:414–420

    Google Scholar 

  27. Haspel MV, Onodera T, Prabhakar BS, McClintock PR, Essani K, Ray UR, Yagihashi S, Notkins AL (1983) Multiple organ-reactive monoclonal autoantibodies. Nature 304:73–76

    Google Scholar 

  28. Panayi GS, Wooley P, Batchelor JR (1978) Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic reactions to drugs. Br Med J 2:1326–1328

    Google Scholar 

  29. Doniach D, Cudworth AG, Khoury EL, Bottazzo GF (1982) Autoimmunity and HLA-system in endocrine diseases. Recent Progr Endocrinol 2:99–132

    Google Scholar 

  30. MacLaren NK, Riley WJ (1986) Inherited susceptibility to autoimmune Addison's disease is linked to human leucocyte antigens DR3 and/or DR4, except when associated with type I autoimmune polyglandular syndrome. J Clin Endocrinol Metab 62:455–459

    Google Scholar 

  31. Mann DL, Moutsopoulos HM (1983) HLA-DR alloantigens in different subsets of patients with Sjögren's syndrome and in family members. Ann Rheum Dis 42:533–536

    Google Scholar 

  32. Arnett FC, Reveille JD, Wilson RW, Provost TT, Bias WB (1984) Systemic lupus erythematosus: current state of the genetic hypothesis. Semin Arthritis Rheum 14:24–35

    Google Scholar 

  33. Chareire J, Karsenty G, Lepage V, Degos L (1984) Presence of thyroid-stimulating immunoglobulins in DR3 positive individuals. In: Albert ED (ed) Histocompatibility testing. Springer, Berlin Heidelberg New York

    Google Scholar 

  34. Scherbaum WA, Youinou PY, Le Goff P, Bottazzo GF (1984) Anti-perinuclear and rheumatoid factor in different forms of autoimmune thyroid disease. Clin Exp Immunol 55:516–518

    Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, University Hospital Medical School, BP 824, F-29285, Brest Cedex, France

    P. Youinou & H. Swirsky

  2. Department of Internal Medicine I, University Hospital of Ulm, D-7900, Ulm, Federal Republic of Germany

    W. Mangold & W. A. Scherbaum

  3. Department of Rheumatology, University Hospital Medical School, BP 824, F-29285, Brest Cedex, France

    J. Jouquan & P. Le Goff

Authors
  1. P. Youinou
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  2. W. Mangold
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  3. J. Jouquan
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  4. H. Swirsky
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  5. P. Le Goff
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  6. W. A. Scherbaum
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Youinou, P., Mangold, W., Jouquan, J. et al. Organ-specific autoantibodies in non-organ-specific autoimmune diseases with special reference to rheumatoid arthritis. Rheumatol Int 7, 123–126 (1987). https://doi.org/10.1007/BF00270464

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  • DOI: https://doi.org/10.1007/BF00270464

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