Abstract
Permanent replacement of the heart in patients with end-stage congestive heart failure has long been sought after as the most definitive solution to an ever-growing problem. While cardiac transplantation is an effective therapy for many patients with end-stage congestive heart failure, this potential has been limited by the donor organ shortage and other limitations of long-term survival inherent in cardiac transplantation. While research anddevelopment of the total artificial heart continues to be of considerable interest, present-day mechanical circulatory support most commonly involves the use of left ventricular assist devices as a bridge to transplantation. Pneumatic and electromechanical pumps are now commonly employed in modern transplant practices with excellent hemodynamic function. The TCI HeartMate left ventricular assist device is now approved by the Food and Drug Administration for clinical implantation, with excellent preliminary results. Advances in the area of temporary and extended mechanical circulatory support are crucial to the ultimate development of a totally implantable artificial heart.
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References
Statistical Abstract of the United States 1994. U.S. Department of Commerce. Lanham, MD: Berman Press.
Farris G, Moore KA, Schroeder JS, Hunt SA, et al. Cardiac transplantation: The Stanford experience in the cyclosporine era. J Thorac Cardiovasc Surg 1994;108:240–252.
1994 Annual Report of the U.S. Scientific Registry of Transplant Recipients and the Organ Procurement and Transplantation Network, UNOS. U.S. Dept. of Health and Human Services, Bethesda, MD.
Cooley DA, Liotta D, Hallman G, et al. First human implantation of a cardiac prosthesis for staged total replacement of the heart. Trans Am Soc Artif Intern Organs 1969;15:252.
Mehta SM, Anfiero TX, Pae WE, Miller CA, Pierce WS. Combined Registry for the Clinical Use of Mechanical Ventricular Assist Pumps and the Total Artificial Heart in Conjunction with Heart Transplantation: Sixth Official Report 1994. J Heart Lung Transplant 1995;14:585–593.
Goldenberg I. Nonpharmacologic management of cardiac arrest and cardiogenic shock. Chest 1992;102:5965–6165.
McGee M, Zillgitt S, Trano R, Turner S, et al. Retrospective analyses of the need for mechanical circulatory support (intra-ortic balloon pump/abdominal left ventricular assist device or partial artificial heart) cardiopulmonary bypass. Am J Cardiol 1980;46:135–142.
Braunwald E, Kloner R. The stunned myocardium—prolonged post ischemic ventricular dysfunction. Circulation 1982;66:1146–1149.
Mority A, Wolner E. Circulatory support with shock due to acute myocardial infarction. Ann Thorac Surg 1993;55:238–244.
Schlant R, Sonnenblick E. Pathophysiology of heart failure. In: Schlant RC, Alexander RW, eds. Hurst's The Heart. New York: McGraw-Hill, 1994:515–555.
Norman J, Cooley DA. Total support of the circulation of patient with postcardiotomy stone heart syndrome by a partial artficial heart (ALVAD) for five days followed heart and kindey transplantation. Lancet 1978;1:1125–1127.
Pennington D, Merjavy J, Swartz M, Codd J, et al. The importance of biventricular failure in patients with postoperative cardiogenic shock. Ann Thorac Surg 1985;39:16–26.
DeBakey ME. Left ventricular bypass pump for cardiac assistance: Clinical experience. Am J Cardiol 1971;27:3–11.
Mavroudis C. To pulse or not to pulse. Ann Thorac Surg 1978;25:259–271.
Bolman R. Circulatory support with a centrifugal pump as a bridge to cardiac transplantation. Ann Thorac Surg 1989; 47:108–112.
Guyton R, Schonberger J, Everts P, Jett G, et al. Postcardiotomy shock: Clinical evaluation of the BVS 5000 Biventricular Support System. Ann Thorac Surg 1993;56:346–356.
Pennington D, McBride L, Peigh P, Miller L, Swartz M. Eight years' experience with bridging to cardiac transplantation. J Thorac Cardiovasc Surg 1994;107:472–481.
Farrar D, Rawson J, Letwak P, Cederwall G. Thoratec VAD system as a bridge to heart transplantation. J Heart Transplant 1990;9:415–423.
Portner P, Oyer P, Pennington DG, et al. Implantable electrical left ventricular assist system: Bridge to transplantation and the future. Ann Thorac Surg 1989;47:142–150.
Frazier OH, Macris M, Myers T, Duncan M, et al. Improved survival after extended bridge to cardiac transplantation. Ann Thorac Surg 1994;57:1416–1422.
Poirier V. The economic burden of artificial hearts. In Nose I, Kjell Strand C, Ivanovich P, eds. Progress in Artificial Organs. Cleveland, OH: ISAO Press, 1986:96–99.
De Vries W, Anderson J, Joyce L, et al. Clinical use of the total artificial heart. N Engl J Med 1984;310:273–278.
Landis DL, Pierce WS, Rosenberg G, et al. Long-term in vivo automatic electronic control of the artificial heart. Trans Am Soc Artif Intern Organs 1977;23:519.
Copeland J, Arabia F, Pavie A, Duveau D, Masters R. Bridge to transplantation with the Cardiowest total artificial heart (abstract). International Society for Heart and Lung Transplantation, 15th Annual Meeting, April 1995.
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Higgins, R.S.D., Silverman, N.A. Status of permanent cardiac replacement for end-stage congestive heart failure. Heart Failure Rev 1, 39–51 (1996). https://doi.org/10.1007/BF00128555
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DOI: https://doi.org/10.1007/BF00128555