Abstract
Acquired neuromuscular diseases or congenital disorders either affect the neuromuscular transmission or the muscle itself. When the neuromuscular transmission is involved, two pathophysiological mechanisms must be distinguished: the abnormality of the nicotinic receptor at the endplate (myasthenia gravis, upregulation of the receptor) and the abnormality of acetylcholine release (Lambert-Eaton myasthenic syndrome, iatrogenic myasthenic syndrome). In both situations pharmacodynamic properties of neuromuscular blocking agents (NMBA) are profoundly affected.1–7
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Plaud, B., Donati, F. (2000). Neuromuscular Blocking Agents and Neuromuscular Diseases. In: Vuyk, J., Engbers, F., Groen-Mulder, S. (eds) On the Study and Practice of Intravenous Anaesthesia. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-9604-6_16
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DOI: https://doi.org/10.1007/978-94-015-9604-6_16
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