Skip to main content

Part of the book series: Developments in Oncology ((DION,volume 60))

  • 124 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Source Material and Selected Further Reading

General Comprehensive Reviews

  1. Alper T (1979) Cellular radiobiology. Cambridge University Press, Cambridge.

    Google Scholar 

  2. Denekamp J (1986) Cell kinetics and radiation biology. Int J Radiat Biol 49: 357–380.

    Article  CAS  Google Scholar 

  3. Denekamp J (1988) Normal tissue response to radiation: experimental. In: Radiobiology in radiotherapy. Ed: NM Bleehen Springer-Verlag London pp. 17–29.

    Google Scholar 

  4. Fowler JF (1983) La Ronde-Radiation sciences and medical radiology. Radiother Oncol 1: 1–22.

    Article  PubMed  CAS  Google Scholar 

  5. Twentyman PR (1988) Radiation response of tumours: experimental. In: Radiobiology in radiotherapy Ed: NM Bleehen Springer-Verlag London pp. 9–15.

    Google Scholar 

Mitotic Cell Death and Mitotic Delay

  1. Denekamp J (1982) Cell kinetics in cancer therapy. Ed: WC Dewey CC Thomas Springfield Illinois.

    Google Scholar 

  2. Nagasawa H, Robertson JB, Arundel CS, Little JB (1984) The effect of X-irradiation on the progression of mouse 10115 cells released from density-inhibited cultures. Radiat Res 97: 537–545.

    Article  PubMed  CAS  Google Scholar 

Radiosensitivity and Position in Cell Cycle

  1. Hall EJ (1988) Radiosensitivity and cell age in the mitotic cycle. In: Radiobiology for the radiologist. JB Lippincott Co Philadelphia pp. 91–106.

    Google Scholar 

  2. Iliakis G, Nusse M (1983) Evidence that repair and expression of potentially lethal damage cause the variations in cell survival after X-irradiation observed through the cell cycle in Ehrlich tumour cells. Radiat Res 95: 87–107.

    Article  PubMed  CAS  Google Scholar 

  3. Sinclair WK, Morton RA (1966) X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Cancer Res 29: 450–474.

    CAS  Google Scholar 

Cell-cell Contact Effect

  1. Durant RE (1984) Repair during multifraction exposures: spheroids versus monolayers. Br J Cancer 49 (Su pl VI): 203–206.

    Google Scholar 

  2. Durand RE, Sutherland RM (1972) Effects of intercellular contact on repair of radiation damage. Exp Cell Res 71: 75–80.

    Article  PubMed  CAS  Google Scholar 

  3. Guichard M, Dertinger H, Malaise EP (1983) Radiosensitivity of four human tumour xenografts. Influence of hypoxia and cell-cell contact. Radiat Res 95: 602–609.

    Google Scholar 

  4. Rasey JS (1983) Cell-cell contact and repair of radiation damage/Review. In: Proceedings of the 7 International Congress of Radiation Research, Reviews and Summaries. Ed. JJ Boerse, GW Barendsen, HB Kald B ran der Kogel Martinus Nijhoff Publishers Amsterdam B7-R: pp. 303–310.

    Google Scholar 

Intrinsic Radiosensitivity (Dose-Survival Curve Parameters Do, Extrapolation Number, Mean Inactivation Dose, 2)

  1. Barendsen GW (1977) Radiosensitivity of tumours and derived cells in culture. Biomedicine 26: 259–260.

    PubMed  CAS  Google Scholar 

  2. Deacon J, Peckham MJ, Steel GG (1984) The radioresponsiveness of human tumours and the initial slope of the cell survival curve. Radiotherap Oncol 2: 317–323.

    Article  CAS  Google Scholar 

  3. Fertil B, Dertinger H, Courdi A, Malaise E (1984) Mean inactivation dose: a useful concept for intercomparison of human cell survival curves. Radiat Res 99: 73–84.

    Article  PubMed  CAS  Google Scholar 

  4. Fertil B, Malaise EP (1981) Inherent cellular radiosensitivity as a basic concept for human tumour radiotherapy. Int J Radiat Oncol Biol Phys 7: 621–629.

    Article  PubMed  CAS  Google Scholar 

  5. Rubin P, Keller B, Quick R (1974) The range of prescribed tumour lethal doses (PTLD) in the treatment of different human tumours, In: The biological and clinical basis of radiosensitivity. Ed: M Friedman Charles, C Thomas Springfield pp. 435–484.

    Google Scholar 

  6. Tucker SL (1986) Is the mean inactivation dose a good measure of cell radiosensitivity7 Radiat Res 105: 18–26.

    CAS  Google Scholar 

Tumour Cell Heterogeneity and Intrinsic Radiosensitivity

  1. Calabresi P, Dexter DL (1982) Clinical implications of cancer cell heterogeneity. In: Tumour cell heterogeneity. Fourth Bristol-Meyer Symposium on Cancer Research. Ed: AH Owen Academic Press Inc NY.

    Google Scholar 

  2. Hill HZ, Hill GJ, Miller CF, Kwong F, Purdy J (1979) Radiation and melanoma response of 816 mouse tumour cells and clonal lines to in vitro irradiation. Radiat Res 80: 259–276.

    Article  PubMed  CAS  Google Scholar 

  3. Leith TJ, Dexter DL, De Wyngaert JK, Zeman EM, Chu MY, Calabresi P, Glicksman AS (1983) Differential responses to X-irradiation of subpopulations of two heterogeneous human carcinoma in vitro. Cancer Res 42: 2556–2561.

    Google Scholar 

  4. Tubiana M (1986) The growth and progression of human tumours: implications for management strategy. Radiother Oncol 6: 167–184.

    Article  PubMed  CAS  Google Scholar 

Intrinsic Radiosensitivity and Repair of Radiation Damage: Evidence of a Correlation

  1. Buick RN, Weichselbaum R, Malaise E (1989) Tumour cell response in vitro. In: Prediction of tumour treatment response. Eds: JD Chapman. LJ Peters, RH Withers Pergamon Press NY pp 187–194.

    Google Scholar 

  2. Deacon JM, Wilson PA, Peckham MJ (1985) The radiobiology of human neuroblastoma. Radiother Oncol 3: 201–209.

    Article  PubMed  CAS  Google Scholar 

  3. Weichselbaum RR (1984) The role of DNA repair in the response of human tumours to fractionated radiotherapy. Int J Radiat Oncol Biol Phys 10: 1127–1134.

    Article  PubMed  CAS  Google Scholar 

  4. Weichselbaum RR, Becket M (1987) The maximum recovery potential of human tumour cells may predict clinical outcome in radiotherapy. Int J Radiat Oncol Biol Phys 13: 709–713.

    Article  PubMed  CAS  Google Scholar 

  5. Weichselbaum RR, Becket MA, Schwartz J, Dritschilo A (1988) Radioresistant tumour cells are present in head and neck carcinomas that recur after radiotherapy. Int J Radiat Oncol Biol Phys 15: 575–579.

    Article  PubMed  CAS  Google Scholar 

  6. Weichselbaum RR, Little JB (1983) X-ray sensitivity and repair in human tumour cells. In: the biological basis of radiotherapy. Eds: GG Steel, GE Adams and MJ Peckham Elsevier Amsterdam pp. 113–121.

    Google Scholar 

Intrinsic Radiosensitivity and Repair of Radiation Damage: Lack of Correlation

  1. Marchese MJ, Zaider M, Hall EJ (1987) Potentially lethal damage repair in human cells. Radiother Oncol 9: 57–65.

    Article  PubMed  CAS  Google Scholar 

  2. Peacock JH, Cassoni AM, McMillan TJ, Steel GG (1988) Radiosensitive human tumour cell lines may not be recovery deficient. Radiat Res 54: 945–953.

    CAS  Google Scholar 

  3. Thraves PJ, Mossman KL, Frazier DMT, Dritschilo A (1986) Inhibition of potentially lethal damage repair in normal and neoplastic cells by 3-aminobenzamide: an inhibitor of poly ( ADP-ribosylation ). Int J Radiat Oncol Biol Phys 12: 1541–1545.

    Google Scholar 

Response to Low Dose Rate As an Indes of Intrinsic Radiosensitivity

  1. Kelland Lr, Steel GG (1988) Differences in radiation response among human cervix carcinoma cell lines. Radiother Oncol 13: 225–232.

    Google Scholar 

  2. Steel GG, Down JD, Peacock JH, Stephens TC (1986) Dose-rate effects and repair of radiation damage. Radiother Oncol 5: 321–331.

    Google Scholar 

The Tumour Bed Effect and Endothelial Proliferation in Tumours

  1. Begg AC, Denekamp J (1983) Stromal damage as a complication in interpretation of tumour growth delay. Eur J Cancer Clin Oncol 19: 1639–1643.

    Article  PubMed  CAS  Google Scholar 

  2. Begg AC, Terry NHA (1984) The sensitivity of normal stroma to fractionated radiotherapy measured by a tumour growth rate assay. Radiother Oncol 2: 333–341.

    Article  PubMed  CAS  Google Scholar 

  3. Denekamp J. Hobson B (1982) Endothelial-cell proliferation in experimental tumours. Br J Cancer 46: 771–720.

    Google Scholar 

  4. Gunduz N (1981) Cytokinetics of tumour and endothelial cells and vascularization of lung metastases in C3H/He mice. Cell Tissue Kinet 14: 343–351.

    PubMed  CAS  Google Scholar 

  5. Hobson B, Denekamp J (1984) Endothelial proliferation in tumours and normal tissues: continued labelling studies. Br J Cancer 49: 405–413.

    Article  PubMed  CAS  Google Scholar 

  6. Milas L, Hunter N, Peters LP (1987) The tumour bed effect: dependence of tumour take, growth rate, and metastases on the time interval between irradiation and tumour cell transplantation. Int J Radiat Oncol Biol Phys 13: 379–383.

    Article  PubMed  CAS  Google Scholar 

Re-Irradiation and the Tumour Bed Effect

  1. Nisar Syed AM, Feder BW, George III FW, Noblest D (1970) Iridium-192 afterloaded implant in the retreatment of head and neck cancers. Br J Radiol 51: 814–820.

    Google Scholar 

  2. van Rotterdam A, Barendsen GW, Gaisser JF (1987) Radiosensitivity of cells in recurrent experimental tumours and the effectiveness of tumour re-treatment. Radiother Oncol 8: 171–176.

    Article  PubMed  Google Scholar 

  3. Skolyszewski J, Korzeniowski S, Reinfuss M (1980) The reirradiation of recurrences of head and neck cancer. BR J Radiol 53: 462–465.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Awwad, H.K. (1990). Tumour Radiation Response: A. Response to a Single Dose. In: Radiation Oncology: Radiobiological and Physiological Perspectives. Developments in Oncology, vol 60. Springer, Dordrecht. https://doi.org/10.1007/978-94-015-7865-3_21

Download citation

  • DOI: https://doi.org/10.1007/978-94-015-7865-3_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-015-7867-7

  • Online ISBN: 978-94-015-7865-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics