Abstract
Approximately 10% of the patients with small-cell lung cancer (SCLC) present with brain metastases at the time of diagnosis [1] and another 40% develop symptomatic CNS involvement during or after treatment [2]. At autopsy approximately 50% will have brain metastases [3], and the cumulative risk of developing brain metastases at two years’ survival is 50%–80% [2, 4]. The prognosis after a cerebral relapse is poor, with a median survival below three months [1, 5], whereas the isolated prognostic impact of CNS involvement at initial diagnosis is minimal [6]. A small fraction of patients will benefit from radiotherapy or chemotherapy and become long-term survivors despite their CNS involvement [7].
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© 1997 Springer Science+Business Media Dordrecht
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Lassen, U., Kristjansen, P.E.G., Hansen, H.H. (1997). Brain metastases in small-cell lung cancer. In: Souhami, R.L. (eds) The Teaching Cases from Annals of Oncology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5456-7_24
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DOI: https://doi.org/10.1007/978-94-011-5456-7_24
Publisher Name: Springer, Dordrecht
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