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Role of Vagal Nerve in Defence Mechanisms against NSAID-Induced Gastrointestinal Mucosal Damage

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Side Effects of Anti-Inflammatory Drugs IV

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Abstract

Many papers suggested only an aggressive role of the vagus nerve on the gastrointestinal (GI) mucosa; however, the essential role of the vagus nerve was proven in GI mucosal defence against different chemicals, e.g. ethanol, HCI, non-steroidal anti-inflammatory drugs (NSAIDs). In order to evaluate the role of the vagus nerve in the development of GI mucosal damage evoked in the rat by the administration of NSAIDs, the present studies were designed to: (1) compare the changes in the NSAID-induced GI mucosal damage after acute surgical and chemical (atropine treatment) vagotomy; (2) investigate the effect of sensory nerve stimulation and chemical deafferentation on the NSAID-induced gastric mucosal damage; (3) evaluate the cytoprotective action of prostacyclin under the above experimental conditions; (4) study the effect of surgical vagotomy on the gastroprotection induced by different drugs.

Gastric mucosal damage was produced by intragastrically (acidified salicylates) or systemically (indomethacin) applied NSAIDs, while the small intestinal and large bowel mucosal injury was produced by systemic indomethacin application.

Results: (1) acute surgical vagotomy aggravated, whereas, chemical vagotomy prevented the GI mucosal damage produced by topically and systemically applied NSAIDs; (2) indomethacin produced significantly more damage in the small intestine than in the large bowel and stomach (order is small intestine > stomach > proximal colon) which is aggravated by acute surgical vagotomy in all these areas of the GI tract; (3) stimulation of capsaicin-sensitive sensory nerves with the capsaicin analogue resiniferatoxin protected against gastric mucosal damage by acidified salicylates and indomethacin; (4) chemical deafferentation enhanced the aspirin-induced gastric mucosal injury, while it did not interfere with the prostacyclin-induced gastric cytoprotection; (5) the mucosal protective effects of PGI2, atropine, cimetidine, sucralfate and scavengers (β-carotene) disappeared after acute surgical vagotomy.

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References

  1. Mózsik Gy, Móron F, Jávor T. Cellular mechanisms of the development of gastric mucosal damage and of gastric cytoprotection induced by prostacyclin in rats. A pharmacological study. Prostagland Leukotriene Med. 1982;9:71–84.

    Article  Google Scholar 

  2. Miller TA. Protective effect of prostaglandins against gastric mucosal damage current knowledge and proposed mechanisms. Am J Physiol. 1983;245:G601–23.

    PubMed  CAS  Google Scholar 

  3. Henagan JM, Smith GS, Seidel ER, Miller TA. Influence of vagotomy on mucosal protection against alcohol-induced gastric damage in the rat. Gastroenterology. 1984;87:903–8.

    PubMed  CAS  Google Scholar 

  4. Mózsik Gy, Király À, Garamszegi M, et al. Failure of prostacyclin, 13-carotene, atropine and cimetidine to produce gastric cyto-and general mucosal protection in surgically vagotomized rats. Life Sci. 1991;49:1383–9.

    Article  PubMed  Google Scholar 

  5. Cho CH, Chen BW, Hui WM, Lam SK, Ogle CW. The role of the vagus nerve in the protective action of acid inhibitors on ethanol-induced gastric mucosal damage in rats. J Gastroenterol Hepatol. 1992;7:178–83.

    Article  PubMed  CAS  Google Scholar 

  6. Poon YK, Cho CH, Ogle CW. Subdiaphragmatic vagotomy attenuates the protective action of paracetamol against ethanol-induced gastric damage in rats. Med Sci Res. 1988;16:1285–90.

    CAS  Google Scholar 

  7. Szabó S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology. 1985;88:228–36.

    PubMed  Google Scholar 

  8. Bell PRF, Battersby C. Effect of vagotomy on gastric mucosal blood flow. Gastroenterology. 1968;54:1032–9.

    PubMed  CAS  Google Scholar 

  9. Seifert J, Lenz J, Bruckner W, Brendel W, Holle F. Are blood flow changes after selective proximal vagotomy responsible for a necrosis in the gastric wall? Res Exp Med. 1980;177:263–6.

    Article  CAS  Google Scholar 

  10. Ahn H, Johansson K, Lindhagen J. Local blood flow changes in association with proximal selective vagotomy. Scand J Gastroenterol. 1986;21:961–4.

    Article  PubMed  CAS  Google Scholar 

  11. Somasundaram K, Ganguly AK. The effect of subdiaphragmatic vagotomy on the gastric mucus barrier in rats. Clin Exp Pharmacol Physiol. 1987;14:735–41.

    Article  PubMed  CAS  Google Scholar 

  12. Sütö G, Király À, Vincze Á, Mózsik Gy. Effect of acute surgical vagotomy on the mucosal content of 6ketolaipha, PGE2 and glutathione after intragastric 96% ethanol treatment in rats. Acta Physiol Hung. 1992;80:205–9.

    PubMed  Google Scholar 

  13. Mózsik Gy, Karádi O, Király Á, Matus Z, Sütö G, Tóth Gy, Vincze Á. Vagal nerve and the gastric mucosal defense. J Physiol (Paris). 1993;87:329–34.

    Article  Google Scholar 

  14. Király Á, Balaskó M, Bódis B, Csontos Zs, Karádi O, Sütä G, Vincze Á, Jávor T, Mózsik Gy. Acute surgical vagotomy (ASV) causes an increased vascular permeability to chemicals in the rat stomach. Dig Dis Sci. 1990;35:1019–21.

    Google Scholar 

  15. Karádi O, Bódis B, Király Á, et al. Surgical vagotomy enhances the indomethacin-induced gastrointestinal mucosal damage in rats. Inflammopharmacology. 1994;2:389–92.

    Article  Google Scholar 

  16. Vincze Á, Király Á, Sütö, G, Mózsik Gy. Changes of gastric mucosal biochemistry in ethanol-treated rats with and without acute surgical vagotomy. J Physiol (Paris). 1993;87:339–41.

    Article  CAS  Google Scholar 

  17. Szolcsányi J, Barthó L. Impaired defense mechanism to peptic ulcer in the capsaicin-desensitized rat. In: Mózsik Gy, Hänninen O, Jávor T, eds. Gastrointestinal Defense Mechanisms. Oxford & Budapest: Pergamon Press & Akademiai Kiadó. 1980:39–51.

    Google Scholar 

  18. Holzer P, Lippe IT. Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of gastric mucosa. Neuroscience. 1988;27:981–7.

    Article  PubMed  CAS  Google Scholar 

  19. Szolcsányi J. Effect of capsaicin, resiniferatoxin and piperine on ethanol-induced gastric ulcer of the rat. Acta Physiol Hung. 1990;75(suppl):267–8.

    PubMed  Google Scholar 

  20. Holzer P, Pabst MA, Lippe IT. Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa. Gastroenterology. 1989;96:1425–33.

    PubMed  CAS  Google Scholar 

  21. Tramontana M, Renzi D, Panerati C, et al. Capsaicin-like effects of resiniferatoxin in the rat stomach. Neuropeptides. 1994;26:29–33.

    Article  PubMed  CAS  Google Scholar 

  22. Gray JL, Bunnett NW, Orloff SL, Mulvihill SJ, Debas HT. Role for calcitonin gene-related peptide in protection against gastric ulceration. Ann Surg. 1993;219:58–64.

    Article  Google Scholar 

  23. Abdel-Salam OME, Bódis B, Karádi O, Szolcsányi J, Mózsik Gy. Modification of aspirin and ethanol-induced mucosal damage in rats by intragastric application of resiniferatoxin. Inflammopharmacology. 1995;3:135–47.

    Article  CAS  Google Scholar 

  24. Abdel-Salam OME, Bódis B, Karádi O, Nagy L, Szolcsányi J, Mózsik Gy. Stimulation of capsaicinsensitive sensory peripheral nerves with topically applied resiniferatoxin decreases salicylate-induced gastric H+ back-diffusion in the rat. Inflammopharmacology. 1995;3:121–33.

    Article  CAS  Google Scholar 

  25. Abdel-Salam OME, Szolcsányi B, Barthó L, Mózsik Gy. Sensory nerve-mediated mechanisms, gastric mucosal damage and its protection: a critical overview. Gastroprotection. 1994;2:4–12.

    Google Scholar 

  26. Evangelista S, Meli A. Influence of capsaicin-sensitive fibers on experimentally-induced colitis in rats. J Pharm Pharmacol. 1989;41:574–5.

    Article  PubMed  CAS  Google Scholar 

  27. Wood JD. Physiology of the enteric nervous system. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York: Raven Press. 1994:423–81.

    Google Scholar 

  28. Abdel-Salam OME, Szolcsányi J, Mózsik Gy. Effect of resiniferatoxin on stimulated gastric acid secretory responses in the rat. J Physiol (Paris). 1995;88:353–8.

    Article  Google Scholar 

  29. Sternini C, Reeve JR, Brecha N. Distribution and characterization of calcitonin gene-related peptide immunoreactivity in the digestive system of normal and capsaicin-treated rats. Gastroenterology. 1987;93:852–62.

    PubMed  CAS  Google Scholar 

  30. Green T, Dockray GJ. Characterization of the peptidergic afferent innervation of the stomach in the rat, mouse and guinea pig. Neuroscience. 1988;25:181–93.

    Article  PubMed  CAS  Google Scholar 

  31. Maggi CA, Evangelista S, Giuliani S, Meli A. Anti-ulcer activity of calcitonin gene-related peptide in rats. Gen Pharmacol. 1987;18:33–4.

    Article  PubMed  CAS  Google Scholar 

  32. Lippe IT, Lorbach M, Holzer P. Close arterial infusion of calcitonin gene-related peptide into the rat stomach inhibits aspirin-and ethanol-induced hemorrhagic damage. Regul Pept. 1989;26:35–46.

    Article  PubMed  CAS  Google Scholar 

  33. Clementi G, Amico-Roxas M, Caruso A, Cutuli VMC, Maugeri S, Prato A. Protective effects of calcitonin gene-related peptide in different experimental models of gastric ulcers. Eur J Pharmacol. 1993;228:101–5.

    Article  Google Scholar 

  34. Back N, Ahonem M, Happöla O, Kivilaakso E, Kiviluoto T. Effect of vagotomy on expression of neuropeptides and histamine in rat oxyntic mucosa. Dig Dis Sci. 1994;39:353–61.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. First Department of Medicine and Department of Pharmacology, Medical University of Pécs, H-7643, Pécs, Hungary

    G. Mózsik, O. M. E. Abdel-Salam, B. Bódis, O. Karádi, L. Nagy & J. Szolcsányi

Authors
  1. G. Mózsik
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  2. O. M. E. Abdel-Salam
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  3. B. Bódis
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  4. O. Karádi
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  5. L. Nagy
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  6. J. Szolcsányi
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Editors and Affiliations

  1. Division of Biomedical Sciences, School of Science and Medicine, Sheffield Hallam University, Sheffield, UK

    K. D. Rainsford

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© 1997 Springer Science+Business Media Dordrecht

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Mózsik, G., Abdel-Salam, O.M.E., Bódis, B., Karádi, O., Nagy, L., Szolcsányi, J. (1997). Role of Vagal Nerve in Defence Mechanisms against NSAID-Induced Gastrointestinal Mucosal Damage. In: Rainsford, K.D. (eds) Side Effects of Anti-Inflammatory Drugs IV. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-5394-2_29

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  • DOI: https://doi.org/10.1007/978-94-011-5394-2_29

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6269-5

  • Online ISBN: 978-94-011-5394-2

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