Skip to main content

Antimyosin Antibody Imaging in Myocardial Infarction

  • Chapter
Clinical Use of Antibodies

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 19))

  • 35 Accesses

Abstract

Antimyosin (Myoscint ™ Centocor Inc. Malvern PA) is a Fab fragment of a specific antibody to myosin heavy chains that binds to necrotic cardiac myocytes. Planar or single photon emission computed tomography (SPECT) techniques using Indium- 111 labelled antibody have been used for the clinical detection of myocardial necrosis, both in acute myocardial infarction, and in myocarditis. This article reviews the role of antimyosin (AM) imaging in myocardial infarction diagnosis and risk stratification.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Khaw B.Aet al(1979) Specificity of localisation of myosin-specific antibody fragments in experimental myocardial infarction: histologie, histochemical, autoradiographic and scintigraphic studies. Circulation 60, 1527–1531

    Article  PubMed  CAS  Google Scholar 

  2. Frame L.H et al (1983) Early membrane damage during coronary reperfusion in dogs: detection by radiolabelled anticardiac myosin (Fab’)2 J. Clin. Invest/ 72, 535–544

    Article  PubMed  CAS  Google Scholar 

  3. khaw B.A. et al (1980) Myocardial infarct imaging of antibodies to canine myosin with Indium-111-diethylene-triaminepentaaceticacid, Science 209, 295–297

    Article  PubMed  CAS  Google Scholar 

  4. Khaw B.A et al (1984) Monoclonal antibody to cardiac myosin: imaging of experimental myocardial infarction, Hybridoma 3, 11–23

    Article  PubMed  CAS  Google Scholar 

  5. Khaw B.A et al (1982) Myocardial injury: quantification by cell sorting initiated with antimyosin fluorescent spheres, Science 217: 1050–1053

    Article  PubMed  CAS  Google Scholar 

  6. Khaw B.A et al (1987) Myocardial damage delineated by indium-111 antimyosin Fab and technetium-99m pyrophosphate. J. Nucl. Med. 28: 76–82

    PubMed  CAS  Google Scholar 

  7. Johnson L.L. et al (1987) Measurementof infarct size and percentagemyocardiuminfarcted in a dog preparation with single photon-emission computed tomography, thallium-201 and indium 111-monoclonal antimyosin Fab. Circulation 76: 181–190

    Article  PubMed  CAS  Google Scholar 

  8. Narula J et al (1990) Documentation of re perfusion myocardial injury by dual radiolabelled anti-myosin imaging: reversibility by membrane stabilising agent. J. Nucl. Med. 31: 805 (Abstract)

    Google Scholar 

  9. Nedelman MA et al (1990) Evaluation of antimyosin uptake in reversiblyinjured (’stunned) myocardium J. Nucl. Med. 31: 783 (Abstract)

    Google Scholar 

  10. Jain D. et al (1988) Postmortem correlation between histopathologic and autoradiographic extent of myocardial necrosis detected by 111-In-antimyosinimagingin a patientswith acute myocardial infarction. Am. J. CardiacImaging 2: 158–161

    Google Scholar 

  11. Jain D et al (1990) Indium-111 antimyosin images compared with triphenyl tetrazolium chloride staining in a patient six days after myocardial infarction. J. Nucl. Med. 31: 231–233

    PubMed  CAS  Google Scholar 

  12. Tamaki N et al (1989) (Clinicaltrial of 111-In-antimyosinantibody imaging (3) Comparison with 99mTc-pyrophosphateimaging) Kaku Igaku 26: 1199–1205

    PubMed  CAS  Google Scholar 

  13. Jain D et al (1989) Late imaging of myocardial infarction with In-111 antimyosin antibodies. Eur.J. Nucl. Med. 15: 474 (Abstract)

    Google Scholar 

  14. Liu XJ et al (1990) A quantitative method for assessing age of myocardial infarction from antimyosin images. J. Nucl. Med. 31: 782 (Abstract)

    Google Scholar 

  15. Jain D et al (1990) Immunoscintigraphyfor the detection of acute myocardial infarction in the absence of electrocardiographicchanges. Br. Med. J. 300: 151–153

    Article  CAS  Google Scholar 

  16. Morguet A et al (1989) Tc-99m methoxy-isobutyl-isonitrile (MIBI) for anatomical landmarking in imaging acute myocardial infarction (AMI) with antimyosin Fab (AM Fab) J. Nucl. Med. 30: 800 (Abstract)

    Google Scholar 

  17. Knapp W.H. et al (1989) In-111 antimyosin antibodies and Tc-99m-MIBIfor assessment of post-infarction myocardial viability. J. Nucl. Med. 30: 800 (Abstract)

    Google Scholar 

  18. Johnson L.L. and Seldin D.W. (1989) The role of antimyosin antibodies in acute myocardial infarction. Semin. Nucl. Med. 19: 238–246

    Article  PubMed  CAS  Google Scholar 

  19. Jain D et al (1988) Discordance between In-111 antimyosin uptake, regional perfusion and wall motion abnormalities in acute Q-wave myocardial infarction. Circulation 78: Supply. 11 431 (Abstract)

    Google Scholar 

  20. Khaw B.A. et al (1989) Scintigraphicquantificationof myocardial necrosis in patients after intravenous injection of myosin-specific antibody. Circulation 74: 501–508

    Article  Google Scholar 

  21. Antunes M.L. et al (1989) Measurement of acute Q-wave myocardial infarct size with single photon emission computed tomography imaging of indium-111 antimyosin. Am. J.Cardiol. 63: 777–783

    Article  PubMed  CAS  Google Scholar 

  22. Volpini M. et al (1989) Diagnosis of acute myocardial infarction by indium-111 antimyosin antibodies and correlation with the traditional techniques for the evaluation of extent and localisation. Am J. Cardiol. 63: 7–13

    Article  PubMed  CAS  Google Scholar 

  23. Berger H. et al (1988) Antimyosin imaging in patients with ischemic chest pain: initial results of phase 111 multicentre trial. J. Nucl. Med. 29 805 (Abstract)

    Google Scholar 

  24. Lahiri A. et al (1990) Combined assessment of myocardial necrosis and left ventricular function with a single dose of In-111 antimyosin J. Nucl. Med. 31: 841 (Abstract)

    Google Scholar 

  25. Khaw B.A. et al (1989) Modification of monoclonal antimyosin antibody: enhanced specificity of localisation and scintigraphic visualisation in acute experimental myocardial infarction. J. Mol. Cell Cardiol. 21:Supply 1. 31–35

    Article  PubMed  CAS  Google Scholar 

  26. Kader K.L. et al (1990) Rapid localisation of In-111 labelled recombinant tissue plasminogen activator in a rabbit thrombosis model J. Nucl. Med. 31: 805 (Abstract)

    Google Scholar 

  27. Chouraqui P. et al (1990) Successful in vivo visualisation of occlusive arterial thrombi by Tc-99m labelled monoclonal antibody against activated platelets. J. Nucl. Med. 30: 713 (Abstract)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Bhattacharya, S., Lahiri, A. (1991). Antimyosin Antibody Imaging in Myocardial Infarction. In: Baum, R.P., Cox, P.H., Hör, G., Buraggi, G.L. (eds) Clinical Use of Antibodies. Developments in Nuclear Medicine, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3516-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-3516-0_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5555-0

  • Online ISBN: 978-94-011-3516-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics