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The Role of Cancer Stem(–Like) Cells and Epithelial-to-Mesenchymal Transition in Spreading Head and Neck Squamous Cell Carcinoma

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Stem Cells and Cancer Stem Cells, Volume 11

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 11))

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth commonest cancer worldwide. Recurrences or metastases, thought to involve cancer stem(−like) cells (CSCs), are common and survival rates remain low. Recently, multiple studies have implicated the link between CSCs and Epithelial-to-mesenchymal transition (EMT) during tumorigenesis. This review aims to summarize some of the key events that are involved in EMT, discusses their relevance in HNSCC progression and metastasis and explores the possibility of targeting EMT as a novel therapy in HNSCC.

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References

  • Babu JM, Prathibha R, Jijith VS, Hariharan R, Pillai MR (2011) A miR-centric view of head and neck cancers. Biochim Biophys Acta 1816:67–72

    PubMed  CAS  Google Scholar 

  • Bao B, Azmi AS, Ali S, Ahmad A, Li Y, Banerjee S, Kong D, Sarkar FH (2012) The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim Biophys Acta 1826:272–296

    PubMed  CAS  Google Scholar 

  • Biddle A, Liang X, Gammon L, Fazil B, Harper LJ, Emich H, Costea DE, Mackenzie IC (2011) Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res 71:5317–5326

    Article  PubMed  CAS  Google Scholar 

  • Bruzzese F, Leone A, Rocco M, Carbone C, Piro G, Caraglia M, Di Gennaro E, Budillon A (2011) HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT. J Cell Physiol 226:2378–2390

    Article  PubMed  CAS  Google Scholar 

  • Chen C, Wei Y, Hummel M, Hoffmann TK, Gross M, Kaufmann AM, Albers AE (2011) Evidence for epithelial–mesenchymal transition in cancer stem cells of head and neck squamous cell carcinoma. PLoS One 6:e16466

    Article  PubMed  CAS  Google Scholar 

  • Chen C, Zimmermann M, Tinhofer I, Kaufmann AM, Albers AE (2012) Epithelial-to-mesenchymal transition and cancer stem(−like) cells in head and neck squamous cell carcinoma. Cancer Lett, http://dx.doi.org/10.1016/j.canlet.2012.06.013

  • Chu PY, Hu FW, Yu CC, Tsai LL, Yu CH, Wu BC, Chen YW, Huang PI, Lo WL (2012) Epithelial-mesenchymal transition transcription factor ZEB1/ZEB2 co-expression predicts poor prognosis and maintains tumor-initiating properties in head and neck cancer. Oral Oncol. doi:10.1016/j.oraloncology.2012.07.012

    Google Scholar 

  • Chung CH, Parker JS, Ely K, Carter J, Yi Y, Murphy BA, Ang KK, El- Naggar AK, Zanation AM, Cmelak AJ et al (2006) Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-kappaB signaling as characteristics of a high- risk head and neck squamous cell carcinoma. Cancer Res 66:8210–8218

    Article  PubMed  CAS  Google Scholar 

  • Cordenonsi M, Zanconato F, Azzolin L, Forcato M, Rosato A, Frasson C, Inui M, Montagner M, Parenti AR, Poletti A et al (2011) The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells. Cell 147:759–772

    Article  PubMed  CAS  Google Scholar 

  • Driessens G, Beck B, Caauwe A, Simons BD, Blanpain C (2012) Defining the mode of tumour growth by clonal analysis. Nature 488:527–530

    Article  PubMed  CAS  Google Scholar 

  • Gialeli C, Theocharis AD, Karamanos NK (2011) Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J 278:16–27

    Article  PubMed  CAS  Google Scholar 

  • Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH (2012) Transcriptional profiling identifies upregulated genes following induction of epithelial–mesenchymal transition in squamous carcinoma cells. Exp Cell Res 318:379–390

    Article  PubMed  CAS  Google Scholar 

  • Jouppila-Matto A, Narkio-Makela M, Soini Y, Pukkila M, Sironen R, Tuhkanen H, Mannermaa A, Kosma VM (2011) Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression. BMC Cancer 11:350

    Article  PubMed  CAS  Google Scholar 

  • Kong D, Li Y, Wang Z, Banerjee S, Ahmad A, Kim HR, Sarkar FH (2009) MiR-200 regulates PDGF-D-mediated epithelial–mesenchymal transition, adhesion, and invasion of prostate cancer cells. Stem Cells 27:1712–1721

    Article  PubMed  CAS  Google Scholar 

  • Kupferman ME, Jiffar T, El-Naggar A, Yilmaz T, Zhou G, Xie T, Feng L, Wang J, Holsinger FC, Yu D et al (2010) TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene 29:2047–2059

    Article  PubMed  CAS  Google Scholar 

  • La Fleur L, Johansson AC, Roberg K (2012) A CD44high/EGFRlow subpopulation within head and neck cancer cell lines shows an epithelial-mesenchymal transition phenotype and resistance to treatment. PLoS One 7:e44071

    Article  PubMed  Google Scholar 

  • Li X, Gao L, Cui Q, Gary BD, Dyess DL, Taylor W, Shevde LA, Samant RS, Dean-Colomb W, Piazza GA et al (2012) Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs. Oncogene 31:4979–4986

    Article  PubMed  CAS  Google Scholar 

  • Lin CH, Shen YA, Hung PH, Yu YB, Chen YJ (2012) Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines. BMC Complement Altern Med 12:201

    Article  PubMed  CAS  Google Scholar 

  • Lo WL, Yu CC, Chiou GY, Chen YW, Huang PI, Chien CS, Tseng LM, Chu PY, Lu KH, Chang KW et al (2011) MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. J Pathol 223:482–495

    Article  PubMed  CAS  Google Scholar 

  • O-Charoenrat P, Rhys-Evans PH, Eccles SA (2001) Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 127:813–820

    PubMed  CAS  Google Scholar 

  • Park SM, Gaur AB, Lengyel E, Peter ME (2008) The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 22:894–907

    Article  PubMed  CAS  Google Scholar 

  • Piao L, Zhang M, Datta J, Xie X, Su T, Li H, Teknos TN, Pan Q (2012) Lipid-based nanoparticle delivery of pre-miR-107 inhibits the tumorigenicity of head and neck squamous cell carcinoma. Mol Ther 20:1261–1269

    Article  PubMed  CAS  Google Scholar 

  • Scanlon CS, Van Tubergen EA, Inglehart RC, D’Silva NJ (2012) Biomarkers of epithelial-mesenchymal transition in squamous cell carcinoma. J Dent Res. doi:10.1177/0022034512467352

    PubMed  Google Scholar 

  • Sterz CM, Kulle C, Dakic B, Makarova G, Bottcher MC, Bette M, Werner JA, Mandic R (2010) A basal-cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9. Oral Oncol 46:116–122

    Article  PubMed  CAS  Google Scholar 

  • Sun Q, Prasad R, Rosenthal E, Katiyar SK (2011) Grape seed proanthocyanidins inhibit the invasive potential of head and neck cutaneous squamous cell carcinoma cells by targeting EGFR expression and epithelial-to-mesenchymal transition. BMC Complement Altern Med 11:134

    Article  PubMed  Google Scholar 

  • Vinci M, Gowan S, Boxall F, Patterson L, Zimmermann M, Court W, Lomas C, Mendiola M, Hardisson D, Eccles SA (2012) Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC Biol 10:29

    Article  PubMed  CAS  Google Scholar 

  • Wang SJ, Bourguignon LY (2006) Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer. Arch Otolaryngol Head Neck Surg 132:771–778

    Article  PubMed  Google Scholar 

  • Wang Z, Li Y, Ahmad A, Azmi AS, Kong D, Banerjee S, Sarkar FH (2010) Targeting miRNAs involved in cancer stem cell and EMT regulation: an emerging concept in overcoming drug resistance. Drug Resist Updat 13:109–118

    Article  PubMed  CAS  Google Scholar 

  • Xia H, Hui KM (2012) MicroRNAs involved in regulating epithelial-mesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics. Cancer Gene Ther 19:723–730

    Article  PubMed  CAS  Google Scholar 

  • Xu T, Yu CY, Sun JJ, Liu Y, Wang XW, Pi LM, Tian YQ, Zhang X (2011) Bone morphogenetic protein-4-induced epithelial–mesenchymal transition and invasiveness through Smad1-mediated signal pathway in squamous cell carcinoma of the head and neck. Arch Med Res 42:128–137

    Article  PubMed  CAS  Google Scholar 

  • Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH (2012) RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol 14:366–374

    Article  PubMed  CAS  Google Scholar 

  • Zuo JH, Zhu W, Li MY, Li XH, Yi H, Zeng GQ, Wan XX, He QY, Li JH, Qu JQ et al (2011) Activation of EGFR promotes squamous carcinoma SCC10A cell migration and invasion via inducing EMT-like phenotype change and MMP-9-mediated degradation of E-cadherin. J Cell Biochem 112:2508–2517

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Cancer Therapeutics, The Institute of Cancer Research, Cotswold Road, Sutton, Surrey, SM2 5NG, UK

    Miriam Zimmermann

  2. Department of Otolaryngology and Head and Neck Surgery, Charité – Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200, Berlin, Germany

    Xu Qian & Andreas E. Albers

  3. Clinic for Gynecology, Gynecologic Tumor Immunology, Charité – Universitätsmedizin Berlin, Charité Campus Benjamin Franklin and Campus Mitte, Hindenburgdamm 30, 12200, Berlin, Germany

    Andreas M. Kaufmann

Authors
  1. Miriam Zimmermann
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  2. Xu Qian
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  3. Andreas M. Kaufmann
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  4. Andreas E. Albers
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Corresponding author

Correspondence to Andreas E. Albers .

Editor information

Editors and Affiliations

  1. Department of Biological Sciences, Kean university, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Zimmermann, M., Qian, X., Kaufmann, A.M., Albers, A.E. (2014). The Role of Cancer Stem(–Like) Cells and Epithelial-to-Mesenchymal Transition in Spreading Head and Neck Squamous Cell Carcinoma. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 11. Stem Cells and Cancer Stem Cells, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7329-5_6

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