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Maintenance of Human Embryonic Stem Cell Identity and Inhibition of Extraembryonic Differentiation: Role of CNOT1, CNOT2 and CNOT3

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Stem Cells and Cancer Stem Cells, Volume 11

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 11))

Abstract

Embryonic stem cells (ESCs) are defined by their capacity to self-renew and differentiate into all adult tissues. They hold the promise to generate models for human development and disease, establish new platforms for drug discovery, and develop therapies for regenerative medicine. To fully realize these potentials, it is crucial to understand the molecular mechanisms controlling ESC self-renewal and differentiation. In this chapter, we discuss the regulators of human ESC self-renewal, with the emphasis on a newly-identified protein complex, Ccr4-Not, in the maintenance of human ESCs and the inhibition of extraembryonic differentiation.

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Authors and Affiliations

  1. Human Pluripotent Stem Cell Core, University of North Carolina at Chapel Hill, 109 Mason Farm Road, 406 Taylor Hall, Chapel Hill, NC, 27599, USA

    Raluca Dumitru

  2. Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Building 101, Room D-416, RTP, 27709, Durham, NC, USA

    Guang Hu

Authors
  1. Raluca Dumitru
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  2. Guang Hu
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Corresponding author

Correspondence to Guang Hu .

Editor information

Editors and Affiliations

  1. Department of Biological Sciences, Kean university, Room 213, Library Building, Union, New Jersey, USA

    M.A. Hayat

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Dumitru, R., Hu, G. (2014). Maintenance of Human Embryonic Stem Cell Identity and Inhibition of Extraembryonic Differentiation: Role of CNOT1, CNOT2 and CNOT3. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 11. Stem Cells and Cancer Stem Cells, vol 11. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7329-5_1

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