Abstract
The process of sprouting angiogenesis is extremely complex involving hundreds of proteins that regulate transcription and participate in signaling pathways controlling cellular movement, proliferation and phenotype alteration. Modeling has been attempted to understand all these mechanisms, and hence, in this chapter, we will focus on models that deal individually with each one of these mechanisms relevant to angiogenesis, as well as with platforms that integrate various models into multiscale models of the whole process.
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Abbreviations
- ARA:
-
Aortic ring assay
- BrDu:
-
Bromodeoxyuridine
- CAM:
-
Chick chorioallantoic membrane
- DII-4:
-
Delta like 4 ligand
- ECM:
-
Extracellular matrix
- FGF:
-
Fibroblast growth factors
- MMPs:
-
Matrix metalloproteases
- MTT:
-
(3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide a yellow tetrazole)
- NRP1:
-
Neuropilin coding gene 1
- NRP2:
-
Neuropilin coding gene 2
- PGC-1α:
-
Proliferator-activated-receptor-gamma co-activator
- RBP-J:
-
Recombining binding protein suppressor of hairless
- VEGF:
-
Vascular endothelial growth factor
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Acknowledgements
RDMT and TMRR thank the support by Fundos FEDER through Programa Operacional Factores de Competitividade – COMPETE and by Fundação para a Ciência e Tecnologia, through the project with reference number FCOMP-01-0124-FEDER-015708. RDMT acknowledges the support of Fundação Calouste Gulbenkian and Fundação para a Ciência e Tecnologia through the Estímulo à Investigaçãoand Ciência 2007programs, respectively. This work was supported by a grant from the Instituto de Salud Carlos III/FIS/FEDER (PI10/00883) awarded to JCRM.
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Quinas-Guerra, M.M., Ribeiro-Rodrigues, T.M., Rodríguez-Manzaneque, J.C., Travasso, R.D.M. (2012). Understanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach. In: Azmi, A.S. (eds) Systems Biology in Cancer Research and Drug Discovery. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4819-4_8
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