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Evidence-based Materia Medica for Cancer Chemoprevention

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Book cover Materia Medica for Various Cancers

Part of the book series: Evidence-based Anticancer Complementary and Alternative Medicine ((ACAM,volume 2))

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Abstract

Cancer is the second leading cause of death in the world, and current therapeutic outcomes are still not satisfactory. Cancer chemoprevention is an important strategy to reduce cancer morbidity by using non- or low-toxic natural or synthetic commodities to prevent and/or reverse the processes of neoplastic initiation and subsequent cancer development. Substantial evidence from human, animal and cell line studies has demonstrated that many herbal products used in traditional Chinese medicine (TCM) and Ayurveda medicine or traditional Indian medicine (TIM) can exert cancer chemopreventive effects. The underlying theories or philosophies for TCM and TIM to prevent cancer are very similar. The common central theme is to bring the patient back to a healthy state by modifying multiple abnormalities in the patient’s body in a holistic manner. Since carcinogenesis involves multiple abnormal gene expressions and signal transduction pathways, using TCM and TIM in cancer chemoprevention may not only be possible, but can be superior to agents aiming at single molecular target. However, before TCM and TIM can be accepted widely as complementary and alternative medicines for cancer prevention, it is crucial to evaluate their clinical efficacy and understand the molecular basis of their effects based on scientific evidence. This chapter highlights major molecular mechanisms in chemoprevention and summarizes the research on ten promising cancer preventive herbal products, including nine from TCM (Danshen, Danggui, Qianghuo, Huangqin, Zicao, Dasuan, Lingzhi, Yunzhi, and Xianggu) and five from TIM (Triphala, Turmeric, Neem, Guggulu, and Sapthaparna). The challenges in developing high quality TCM and TIM cancer preventive products are discussed and an integrated strategy is proposed to facilitate the process.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, 91766, USA

    Sunil Prabhu, Ying Huang & Jeffrey Wang

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  1. Sunil Prabhu
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  2. Ying Huang
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  3. Jeffrey Wang
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Correspondence to Jeffrey Wang .

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  1. Queen Elizabeth Hospital, Department of Clinical Oncology, Room 1305, 13/F, Block R, Gascoigne Road 30, Kowloon, Hong Kong, China, People's Republic

    William C.S. Cho

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Prabhu, S., Huang, Y., Wang, J. (2012). Evidence-based Materia Medica for Cancer Chemoprevention. In: Cho, W. (eds) Materia Medica for Various Cancers. Evidence-based Anticancer Complementary and Alternative Medicine, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-1983-5_15

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