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Advances in Cognitive Neurodynamics (II) pp 47–57Cite as

Spontaneous Low-Frequency Fluctuation Observed with Functional Magnetic Resonance Imaging as a Potential Biomarker in Neuropsychiatric Disorders

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Abstract

As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain’s spontaneous activity, they have revealed fMRI’s potential to locate changes in brain hemodynamics in neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in spontaneous low-frequency fluctuation (SLFF) observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. In this paper, we review the methods used to study SLFF from individual region of interest analysis, to local network analysis, to whole brain network analysis. We also summarize the major findings associated with major neurological and psychiatric disorders obtained using these methods.

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Acknowledgments

The authors thank Drs. Rhoda E. and Edmund F. Perozzi for English language assistance. This work was supported by the Natural Science Foundation of China (Grant No. 30425004 and Grant No. 30730035), and the National Key Basic Research and Development Program (973) (Grant No. 2007CB512304).

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Authors and Affiliations

  1. Center for Social and Economic Behavior, Institute of Psychology, Chinese Academy of Sciences, Beijing, PR. China

    Yuan Zhou

  2. National Laboratory of Pattern Recognition, LIAMA Center for Computational Medicine, Institute of Automation, Chinese Academy of Sciences, Beijing, PR. China

    Yuan Zhou, Kun Wang, Yong Liu, Ming Song, Sonya W. Song & Tianzi Jiang

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  1. Yuan Zhou
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  4. Ming Song
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  6. Tianzi Jiang
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Correspondence to Tianzi Jiang .

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Editors and Affiliations

  1. , Institute for Cognitive Neurodynamics, East China University of Science and Tec, Meilong Road 130, Shanghai, 200237, China, People's Republic

    Rubin Wang

  2. Fudan University, Shanghai, China, People's Republic

    Fanji Gu

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Zhou, Y., Wang, K., Liu, Y., Song, M., Song, S.W., Jiang, T. (2011). Spontaneous Low-Frequency Fluctuation Observed with Functional Magnetic Resonance Imaging as a Potential Biomarker in Neuropsychiatric Disorders. In: Wang, R., Gu, F. (eds) Advances in Cognitive Neurodynamics (II). Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9695-1_7

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