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Mannan-Binding Protein (MBP)-Ligand Glycans: A Novel Tissue Marker for Colorectal Carcinomas

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Glycoscience: Biology and Medicine

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Abstract

Mannan-binding protein (MBP) is a C-type serum lectin that plays a key role in innate immunity. MBP exhibits broad specificity for mannose, N-acetylglucosamine, and fucose. Several years ago, highly fucosylated high molecular weight type 1 Lewis glycans were isolated as MBP-ligands from human colorectal carcinoma (SW1116) cells. Recently, MBP was demonstrated to recognize human primary colorectal carcinoma tissues through tumor-associated MBP-ligands. MBP-ligands were expressed in 127 of 330 patients (38.5 %), whereas, most significantly, there was no MBP-ligand expression in 69 nonmalignant tissues. In addition, the MBP staining correlated inversely with the expression of CA19-9 (sialyl Lewis a), and MBP stained 11 of 25 (44 %) CA19-9-negative colorectal carcinoma tissues. Furthermore, a favorable prognosis was found in patients with MBP-ligand-positive tumors. These results suggest that selective recognition of cancer cells by endogenous MBP may be associated with an antitumor effect and that tissue staining with MBP in combination with CA19-9 antibody may serve as a novel indicator of colorectal carcinoma tissues.

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Authors and Affiliations

  1. Research Center for Glycobiotechnology, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga, 525-8577, Japan

    Toshisuke Kawasaki & Nobuko Kawasaki

  2. Sanford-Burnham Medical Research Institute, Cancer Center, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Motohiro Nonaka

Authors
  1. Toshisuke Kawasaki
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  2. Motohiro Nonaka
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  3. Nobuko Kawasaki
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Corresponding author

Correspondence to Toshisuke Kawasaki .

Editor information

Editors and Affiliations

  1. Tokyo Metropolitan Institute of Gerontology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan

    Tamao Endo

  2. Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Potsdam, Germany

    Peter H. Seeberger

  3. Dept. Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Gerald W. Hart

  4. Academia Sinica, Nankang, Taipei, Taiwan

    Chi-Huey Wong

  5. Systems Glycobiology Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Wako, Saitama, Japan

    Naoyuki Taniguchi

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© 2014 Springer Japan

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Kawasaki, T., Nonaka, M., Kawasaki, N. (2014). Mannan-Binding Protein (MBP)-Ligand Glycans: A Novel Tissue Marker for Colorectal Carcinomas. In: Endo, T., Seeberger, P., Hart, G., Wong, CH., Taniguchi, N. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54836-2_60-1

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  • DOI: https://doi.org/10.1007/978-4-431-54836-2_60-1

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  • Publisher Name: Springer, Tokyo

  • Online ISBN: 978-4-431-54836-2

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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