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Anti-inflammatory properties of MMP inhibitors in experimental models of chronic obstructive pulmonary disease and lung inflammation

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Matrix Metalloproteinases in Tissue Remodelling and Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Matrix metalloproteinases (MMPs) are a group of proteases known to regulate the turnover of extracellular matrix and thus are suggested to be important in the process of lung disease associated with tissue remodelling. Furthermore, the concept that modulation of airway remodelling including excessive proteolysis damage of the tissue, may be of interest as a basis for future treatment. Among the metalloproteinases (MMPs) family, macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodelling processes in chronic obstructive pulmonary disease including emphysema. Recent studies using broad spectrum MMP or dual MMP-9/MMP-12 inhibitors have demonstrated a reduction in both inflammatory process and airspace enlargement in lung tissue. In the present chapter, we also report the inhibitory activity of a new MMP-9/MMP-12 inhibitor, AS112108, on acute lung inflammatory processes induced by cigarette smoke.

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Author information

Authors and Affiliations

  1. INSERM U620, Faculté de Pharmacie, Université de Rennes 1, 2, avenue du Pr. Léon Bernard, 35043, Rennes, France

    Catherine le Quément, Vincent Lagente, Isabelle Guénon & Elisabeth Boichot

  2. LCG-RBM, Istituto di Ricerche Biomediche “Antoine Marxer”, 1 Via Ribes, 10010, Colleretto Giacosa, Italy

    Valeria Muzio

  3. Merck-Serono International S.A., 9 Chemin des Mines, 1211, Geneva 20, Switzerland

    Jean-Yves Gillon

Authors
  1. Catherine le Quément
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  2. Vincent Lagente
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  3. Isabelle Guénon
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  4. Valeria Muzio
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  5. Jean-Yves Gillon
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  6. Elisabeth Boichot
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Editors and Affiliations

  1. INSERM U620 Faculté des Sciences Pharmaceutiques et Biologique, Université de Rennes 1, Avenue du Professeur Léon Bernard 2, 35043, Rennes CX, France

    Vincent Lagente  & Elisabeth Boichot  & 

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© 2008 Birkhäuser Verlag Basel/Switzerland

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le Quément, C., Lagente, V., Guénon, I., Muzio, V., Gillon, JY., Boichot, E. (2008). Anti-inflammatory properties of MMP inhibitors in experimental models of chronic obstructive pulmonary disease and lung inflammation. In: Lagente, V., Boichot, E. (eds) Matrix Metalloproteinases in Tissue Remodelling and Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8585-9_4

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