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Localized Hyperthermia for the Treatment of Cerebral Tumors

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Advanced Intraoperative Technologies in Neurosurgery

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Abstract

Hyperthermia is a cancer-treatment modality that can cause tumor necrosis by concentrated heating of tumor tissue. The treatment of human tumors by the application of heat is an idea rooted in antiquity. Both Hippocrates (400 BC) and Galen (200 AD) described the palliative effects of red-hot irons applied to superficial tumors. A more recent rationale for hyperthermia in cancer therapy was based on the observation that patients with high fevers had spontaneous remissions of their tumor. In 1893, Coley described tumor responses to bacterial toxin therapy associated with fevers of 39–40 °C of several days duration 1. Although hyperthermia has been of historical interest for some time, in the last two decades it has reemerged as an investigational therapy. The renewed interest is due, in part, to the crucial observation by Cavaliere et al. (1967), that tumor cells are selectively thermosensitive compared to normal cells at temperatures between 42–45 In addition, data from in vitro, animal, and human studies have shown an additive or synergistic response between heat and chemotherapy, and heat and radiation therapy, at 41–43 °C Furthermore, today’s hyperthermia technology, although still in its infancy, has the capability of producing therapeutic temperatures with minimal morbidity to the host. Thus, a new modality has emerged coincident with the realization that standard cancer therapy—surgery, radiation, chemotherapy—can cure only one of three afflicted patients.

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References

  1. Coley, W. B., 1893: The treatment of malignant tumors by repeated innoculations of erysipelas: with a report of 10 original cases. Amer. J. Med. Sci. 705, 487–511.

    Article  Google Scholar 

  2. Cavaliere, R., Ciocatto, E. C., Giovanella, B. C., Heidelberger, C., Johnson, R. O., Margottini, M., Mondovi, B., Moricca, G., Rossi-Fanelli, A., 1967: Selective heat sensitivity of cancer cells: Biochemical and chnical studies. Cancer 20, 1351–1381.

    Article  PubMed  CAS  Google Scholar 

  3. Hahn, G. M., Li, G. C., 1982: Interactions of hyperthermia and drugs: Treatments and probes. J. Nat. Cancer. Inst. Monogr. 61, 317–323.

    CAS  Google Scholar 

  4. Stehlin, J. S., Giovanella, B. C., Ipolyi, P. D., Mueg, L. R., Anderson, R. F., 1975: Results of hyperthermic perfusion for melanoma of the extremities. Surg. Gynec. Obstet. 140, 339–348.

    PubMed  CAS  Google Scholar 

  5. Kim, J. H., Hahn, E. W., Tokita, N., Nisce, L. Z., 1977: Local tumor hyperthermia in combination with radiation therapy. Cancer 40, 161–169.

    Article  PubMed  CAS  Google Scholar 

  6. Hornbeck, N. B., Shupe, R. E., Shidnia, H., Joe, B. T., Sayoc, E., Marshall, C., 1977: Prehminary chnical results of combined 433 MHz microwave therapy and radiation therapy on patients with advanced cancer. Cancer 40, 2854–2863.

    Article  Google Scholar 

  7. Salcman, M., 1980: Ghoblastoma multiforme. Amer. J. Med. Sci. 279, 84–94.

    Article  PubMed  CAS  Google Scholar 

  8. Zimm, S., Wampler, G. L., Stablein, D., Hazra, T., Young, H. F., 1981: Intracerebral metastases in sohd-tumor patients: Natural history and results of treatment. Cancer 48, 384–394.

    Article  PubMed  CAS  Google Scholar 

  9. Mückle, D. S., Dickson, J. A., 1972: The selective inhibitory effect of hyperthermia on the metabohsm and growth of mahgnant cells. Br. J. Cancer 5, 771–778.

    Google Scholar 

  10. Mondovi, B., Finazzi-Agro, A., Rotiho, G., Strom, R., Moricca, G., Rossi- Fanelh, A., 1969: The biochemical mechanism of selective heat sensitivity of cancer cells. II. Studies on nucleic acids and protein synthesis. Eur. J. Cancer 5, 137–147.

    Article  PubMed  CAS  Google Scholar 

  11. Strom, R., Santoro, A. S., Crifo, C., Bozzi, A., Mondovi, B., Rossi-Fanelh, A., 1973: The biochemical mechanism of selective heat sensitivity of cancer cells. IV. Inhibition of RNA synthesis. Eur. J. Cancer 9, 103–112.

    Article  PubMed  CAS  Google Scholar 

  12. Hahn, G. M., 1975: Thermochemotherapy: Interactions between hyperthermia and chemotherapeutic agents. In: Proc. Int. Symp. on Cancer Therapy by Hyperthermia and Rad. Washington, D.C. Amer. Coll. Rad. Press, pp. 61–65.

    Google Scholar 

  13. Strom, R., 1970: Ricerche sul meccanismo d’azione del calore sui tumori. Atti. Soc. Ital. Cancer. V. Nat. Congr. Vol. 7, Part 2, 49–60.

    Google Scholar 

  14. Turano, C., Perraro, A., Strom, R., Cavaliere, R., Rossi-Panelh, A., 1970: The biochemical mechanism of selective heat sensitivity of cancer cehs. III. Studies on lysosomes. Eur. J. Cancer 6, 67–72.

    Article  PubMed  CAS  Google Scholar 

  15. Dickson, J. A., Calderwood, S. K., 1983: Thermosensitivity of neoplastic tissues in vivo. In: Hyperthermia in Cancer Therapy (Storm, P. K., ed.), pp. 63–140. Boston: G. K. HaU.

    Google Scholar 

  16. Hardy, J. D., Stolwijk, J. A. J., Hammel, H. T., 1965: Skin temperature and cutaneous pain during warm water immersion. J. Appi. Physiol. 20, 1014—1021.

    CAS  Google Scholar 

  17. Westermark, N., 1927: The effect of heat upon rat tumors. Skand. Arch. Physiol. 52, 257–322.

    Google Scholar 

  18. Crile, G., 1962: Selective destruction of cancers after exposure to heat. Ann. Surg. 156, 404–407.

    Article  PubMed  Google Scholar 

  19. Mantyla, M. J., 1979: Regional blood flow in human tumors. Cancer Res.39, 2304–2306.

    PubMed  CAS  Google Scholar 

  20. Storm, P. K., Elhott, R. S., Harrison, W. H., Morton, D. L., 1979: Normal tissue and sohd tumor effects of hyperthermia in animal models and chnical trials. Cancer Res. 39, 2245–2251.

    PubMed  CAS  Google Scholar 

  21. Doss, J. D., 1975: Use of RP fields to produce hyperthermia in animal tumors. Proc. Int. Symp. on Cancer Therapy by Hyperthermia and Rad, pp. 226–227. Washington, D.C.: Amer. Coll. Rad. Press.

    Google Scholar 

  22. Sternhagen, C. J., Doss, J. D., Day, P. W., Edwards, W. S., Doberneck, R. C., Herzon, P. S., Powell, T. D., O’Brien, G. P., Larkin, J. M., 1978: Clinical use of radiofrequency current in oral cavity carcinomas and metastatic mahgnancies with continuous temperature control and monitoring. In: Cancer Therapy by Hyperthermia and Rad. (Streffer, C., ed.), pp. 331–334. Baltimore: Urban & Schwarzenberg.

    Google Scholar 

  23. Rand, R. W., Snow, H. D., Brown, W. J., 1982: Thermomagnetic surgery for cancer. J. Surg. Res. 33, 177–183.

    Article  PubMed  CAS  Google Scholar 

  24. Lele, P. P., 1975: Hyperthermia by ultrasound. In: Proc. Int. Symp. on Cancer Therapy by Hyperthermia and Rad., pp. 168–178. Washington, D.C.: Amer. Coll. Rad. Press

    Google Scholar 

  25. Schwan, H. P., 1980: Electromagnetic and ultrasonic induction of hyperthermia in tissue-hke substances. Radiat. Environ. Biophys. 17,189–203.

    Article  PubMed  CAS  Google Scholar 

  26. Guy, A. W., Chou, C. K., 1983: Physical aspects of localized heating by radiowaves and microwaves. In: Hyperthermia in Cancer Therapy (Storm, P. K., ed.), pp. 279–304. Boston: G. K. Hah.

    Google Scholar 

  27. Le Veen H. H., Wapnick, S., Piccone, V., Palk, G., Ahmed, N., 1976: Tumor eradication by radiofrequency therapy. Response in 21 patients. J.A.M.A. 235, 2198–2200.

    Article  Google Scholar 

  28. Storm, P. K., 1983: Hyperthermia in Cancer Therapy. Boston: G. K. Hall, Medical Publ.

    Google Scholar 

  29. Lehmann, F. J., 1982: Therapeutic Heat and Cold, 3rd ed. Baltimore: Wilhams and Wilkins.

    Google Scholar 

  30. Third Int. Symposium: Cancer therapy by hyperthermia, drugs, and radiation. NCI Monograph 61, 1982.

    Google Scholar 

  31. Walker, M. D., Green, S. B., Byar, D. P., et al., 1980: Randomized comparisons of radiotherapy and nitrosoureas for the treatment of mahgnant ghoma after surgery. NEJM 303, 1323–1329.

    Article  PubMed  CAS  Google Scholar 

  32. Storm, F. K., Harrison, W. H., Elhott, R. S., Hatzitheofilou, C., Morton, D. L., 1979: Human hyperthermic therapy: Relationship between tumor type and capacity to induce hyperthermia by radiofrequency. Amer. J. Surg. 138, 170- 174.

    Google Scholar 

  33. Storm, F. K., Harrison, W. H., Elhott, R. S., Morton, D. L., 1980: Hyperthermic therapy for human neoplasms: Thermal death time. Cancer 46, 1849–1854.

    Article  PubMed  CAS  Google Scholar 

  34. Storm, F. K., Harrison, W. H., Elhott, R. S., Kaiser, L. R., Silberman, A. W., Morton, D. L., 1981: Chnical radiofrequency hyperthermia by magnetic-loop induction. J. Microwave Power 16, 179–184.

    CAS  Google Scholar 

  35. Storm, F. K., Morton, D. L., Kaiser, L. R., Harrison, W. H., Elhott, R. S., Weisenburger, T. H., Parker, R. G., Haskell, C. M., 1982: Clinical radiofrequency hyperthermia: A review. J. Natl. Cancer. Inst. Monogr. 61, 343–350.

    CAS  Google Scholar 

  36. Elhott, R. S., Harrison, W. H., Storm, F. K., 1982: Electromagnetic heating of deep-seated tumors. IEEE. Trans. Biomed. Engin. 29, 61–64.

    Article  Google Scholar 

  37. Storm, F. K., Harrison, W. H., Elhott, R. S., Silberman, A. W., Morton, D. L., 1982: Thermal distribution of magnetic-loop induction hyperthermia in phantoms and animals: Effect of the hving state and velocity of heating. Int. J. Rad. Oncol. Biol. Phys. 8, 865–871.

    CAS  Google Scholar 

  38. Baker, H. W., Snedecor, P. A., Goss, J. C., Galen, W. P., Gallucci, P., Horowitz, I. J., Dugan, K., 1982: Regional hyperthermia for cancer. Amer. J. Surg.143, 586–590.

    Article  PubMed  CAS  Google Scholar 

  39. Storm, F. K., Silberman, A. W., Ramming, K. P., Kaiser, L. R., Harrison, W. H., Elhott, R. S., Haskell, C. M., Sarna, G., Morton, D. L., 1984: Chnical thermochemotherapy: A controlled trial in advanced cancer patients. Cancer 53, 863–868.

    Article  PubMed  CAS  Google Scholar 

  40. Silberman, A. W., Morgan, D. F., Storm, F. K., Rand, R. W., Bubbers, J. E., Brown, W. J., Morton, D. L., 1982: Localized magnetic-loop induction hyperthermia of the rabbit brain. J. Surg. Oncol.20, 174–178.

    Article  PubMed  CAS  Google Scholar 

  41. Krainer, L., 1949: Lamellar atrophy of the purkinje cells following heat stroke. Arch. Neuro. Psychiat. 51, 441–444.

    Google Scholar 

  42. Morgan, D. F., Silberman, A. W., Bubbers, J. E., Rand, R. W., Storm, F. K., Morton, D. L., 1982: An experimental brain tumor model in rabbits. J. Surg. Oncol. 20, 218–220.

    Article  PubMed  CAS  Google Scholar 

  43. Silberman, A. W., Morgan, D. F., Storm, F. K., Rand, R. W., Benz, M., Drury, B., Morton, D. L., 1984: Combination radiofrequency hyperthermia and chemotherapy (BCNU) for brain mahgnancy: Animal experience and two case reports. J. Neuro-Oncol. 2, 19–28.

    Article  CAS  Google Scholar 

  44. Silberman, A. W., Rand, R. W., Storm, F. K., Drury, B., Benz, M. L., Morton, D. L., 1985: Phase I trial of thermochemotherapy for brain mahgnancy. Cancer 56, 48–56.

    Article  PubMed  CAS  Google Scholar 

  45. Storm, F. K., Baker, H. W., Scanlon, E. P., et al, 1985: Magnetic-induction hyperthermia: Results of a 5-year multi-institutional national cooperative trial in advanced cancer patients. Cancer 55, 2677–2687.

    Article  PubMed  CAS  Google Scholar 

  46. Thuning, C. A., Bakir, N. A., Warren, J., 1980: Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma. Cancer Res.40, 2726–2729.

    PubMed  CAS  Google Scholar 

  47. Rosner, D., Nemoto, T., Pickren, J., Lane, W., 1983: Management of brain metastases from breast cancer by combination chemotherapy. J. Neuro-Oncol. 1, 131–137.

    Article  CAS  Google Scholar 

  48. Olch, A. J., Kaiser, L. R., Silberman, A. W., Storm, P. K., Graham, L. S., Morton, D. L., 1983: Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an apphcable physiological model. J. Surg. Oncol. 23, 125–132.

    Article  PubMed  CAS  Google Scholar 

  49. Goldsmith, M. A., Carter, K. S., 1974: Ghoblastoma multiforme—A review of therapy. Cancer. Treat. Rev. 1, 153–165.

    Article  Google Scholar 

  50. Levin, V. A., Crafts, D. C., Norman, D. M., Hoffer, P. B., Spire, J. P., Wilson, C. B., 1977: Criteria for evaluating patients undergoing chemotherapy for malignant brain tumors. J. Neurosurg. 47, 329–335.

    Article  PubMed  CAS  Google Scholar 

  51. Egan, R. T., Scott, M., 1983: Evaluation of prognostic factors in chemotherapy of recurrent brain tumors. J. Chn. Oncol. 1, 38–44.

    Google Scholar 

  52. Lin, J. C., Lin, M. P., 1982: Microwave hyperthermia-induced blood-brain barrier alterations. Rad. Res. 89, 77–87.

    Article  CAS  Google Scholar 

  53. Lin, J. C., Lin, M. P., 1984: Blood-brain barrier changes under microwave hyperthermia. Hyperthermic. Oncol. 1, 737–738. Abstract.

    Google Scholar 

  54. Britt, R. H., Lyons, B. E., Pounds, D. W., Prionas, S. D., 1983: Feasibihty of ultrasound hyperthermia in the treatment of mahgnant brain tumors. Med. Instrum. 17, 172–177.

    PubMed  CAS  Google Scholar 

  55. Samaras, G. M., Salcman, M., Chung, A. Y., Abdo, H. S., Schepp, R. S., 1982: Microwave-induced hyperthermia: An experimental adjunct for brain tumor therapy. Natl. Cancer. Inst. Monogr. 61, 477–482.

    Google Scholar 

  56. Salcman, M., Kaplan, R. S., Samaras, G. M., Ducker, T. B., Broadweh, R. D., 1982: Aggressive multimodahty therapy based on a multicompartmental model of ghoblastoma. Surg. 92, 250–259.

    CAS  Google Scholar 

  57. Salcman, M., Samaras, G. M., 1983: Interstitial microwave hyperthermia for brain tumors. J. Neuro-Oncol. 1, 225–236.

    Article  CAS  Google Scholar 

  58. Yamada, N., Tanaka, R., Kanayama, T., Suzuki, Y., Takeda, N., Sekiguchi, K., Saito, Y., 1984: The influence of hyperthermia on cerebral functions— blood flow, metabohsm and electroencephalography. Hyperthermic. Oncol. 4, T1,. Abstract.

    Google Scholar 

  59. Tanaka, R., Kim, C. H., Yamada, M., Saito, Y., 1984: RP hyperthermia of experimental brain tumor. Hyperthermic. Oncol. 4, T5. Abstract.

    Google Scholar 

  60. Tanaka, R., Yamada, N., Kim, C. H., Saito, Y., 1984: RP hyperthermia of human mahgnant brain tumor. Hyperthermic. Onco. 4, T6. Abstract.

    Google Scholar 

  61. Sutton, C. H., 1984: Invasive hyperthermia and chemotherapy for the treatment of mahgnant ghomas of the brain. Hyperthermic. Oncol. 4, T7. Abstract

    Google Scholar 

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Authors and Affiliations

  1. Division of Surgical Oncology, John Wayne Cancer Clinic, Division of Neurosurgery, Department of Surgery, UCLA School of Medicine, Los Angeles, California, USA

    Allan W. Silberman & Robert W. Rand

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  1. Allan W. Silberman
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  2. Robert W. Rand
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Editors and Affiliations

  1. Institute of Neurosurgery, University of Turin, Italy

    Victor Aldo Fasano (Director) (Director)

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© 1986 Springer-Verlag/Wien

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Silberman, A.W., Rand, R.W. (1986). Localized Hyperthermia for the Treatment of Cerebral Tumors. In: Fasano, V.A. (eds) Advanced Intraoperative Technologies in Neurosurgery. Springer, Vienna. https://doi.org/10.1007/978-3-7091-8810-1_24

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  • DOI: https://doi.org/10.1007/978-3-7091-8810-1_24

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-8812-5

  • Online ISBN: 978-3-7091-8810-1

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