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Advances in Experimental Cell Biology and Cell-Material Interactions

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Materiomics: Multiscale Mechanics of Biological Materials and Structures

Part of the book series: CISM International Centre for Mechanical Sciences ((CISM,volume 546))

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Abstract

Recent advances in the physical sciences and engineering have made it possible to measure and manipulate the mechanical and binding properties of cells in new ways. In this chapter, we will introduce this field by discussing two different experimental approaches at the interface of biology and engineering: 1) ways to measure the different types of forces generated by the actin cytoskeleton and 2) how we can probe the interactions between cells and their environment using nanostructured surfaces.

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Bibliography

  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter. Molecular Biology of the Cell. Garland Science, New York, 5 edition, July 2008.

    Google Scholar 

  • Marco Arnold, E Ada Cavalcanti-Adam, Roman Glass, Jacques Blümmel, Wolfgang Eck, Martin Kantlehner, Horst Kessler, and Joachim P Spatz. Activation of Integrin Function by Nanopatterned Adhesive Interfaces. ChemPhysChem, 5(3):383–388, January 2004.

    Article  CAS  Google Scholar 

  • Marco Arnold, Marco Schwieder, Jacques Bluemmel, E Ada Cavalcanti-Adam, Monica Lopez-Garcia, Horst Kessler, Benjamin Geiger, and

    Google Scholar 

  • Joachim P Spatz. Cell interactions with hierarchically structured nanopatterned adhesive surfaces. Soft Matter, 5(1):72–77, January 2009.

    Article  Google Scholar 

  • Jacques Bluemmel, Nadine Perschmann, Daniel Aydin, Jovana Drinjakovic, Thomas Surrey, Monica Lopez-Garcia, Horst Kessler, and Joachim P Spatz. Protein repellent properties of covalently attached PEG coatings on nanostructured SiO(2)-based interfaces. Biomaterials, 28(32):4739–4747, November 2007.

    Article  CAS  Google Scholar 

  • William Brieher, Margaret Coughlin, and Timothy Mitchison. Fascinmediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. The Journal of Cell Biology, 165(2): 233–42, 2004.

    Article  CAS  Google Scholar 

  • Lisa Cameron, Matthew Footer, Alexander van Oudenaarden, and Julie Theriot. Motility of ActA protein-coated microspheres driven by actin polymerization. Proceedings of the National Academy of Sciences of the United States of America, 96(9):4908–13, April 1999.

    Article  CAS  Google Scholar 

  • E Ada Cavalcanti-Adam, Alexandre Micoulet, Jacques Bluemmel, Jörg Auernheimer, Horst Kessler, and Joachim P Spatz. Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly. European Journal of Cell Biology, 85(3-4):219–224, January 2006.

    Article  CAS  Google Scholar 

  • E Ada Cavalcanti-Adam, Daniel Aydin, Vera Catherine Hirschfeld-Warneken, and Joachim P Spatz. Cell adhesion and response to synthetic nanopatterned environments by steering receptor clustering and spatial location. HFSP Journal, 2(5):276–285, October 2008.

    Article  CAS  Google Scholar 

  • Adam J Engler, Shamik Sen, H Lee Sweeney, and Dennis E Discher. Matrix Elasticity Directs Stem Cell Lineage Specification. Cell, 126(4):677–689, August 2006.

    Article  CAS  Google Scholar 

  • Matthew Footer, Jacob Kerssemakers, Julie Theriot, and Marileen Dogterom. Direct measurement of force generation by actin filament polymerization using an optical trap. Proceedings of the National Academy of Sciences of the United States of America, 104(7):2181–6, February 2007.

    Article  CAS  Google Scholar 

  • Benjamin Geiger, Alexander Bershadsky, Roumen Pankov, and Kenneth M Yamada. Transmembrane crosstalk between the extracellular matrixcytoskeleton crosstalk. Nature Reviews Molecular Cell Biology, 2(11): 793–805, November 2001.

    Article  CAS  Google Scholar 

  • Filippo G Giancotti and Erkki Ruoslahti. Integrin Signaling. Science, 285 (5430):1028–1033, August 1999.

    Article  CAS  Google Scholar 

  • Philippe P Girard, E Ada Cavalcanti-Adam, Ralf Kemkemer, and Joachim P Spatz. Cellular chemomechanics at interfaces: sensing, integration and response. Soft Matter, 3:307–326, January 2007.

    Article  CAS  Google Scholar 

  • Vera Hirschfeld-Warneken, Marco Arnold, E Ada Cavalcanti-Adam, M Lopez-Garcia, Horst Kessler, and Joachim P Spatz. Cell adhesion and polarisation on molecularly defined spacing gradient surfaces of cyclic RGDfK peptide patches. European Journal of Cell Biology, 87(8-9):743–750, June 2008.

    Article  CAS  Google Scholar 

  • Hayden Huang, Roger D Kamm, and Richart T Lee. Cell mechanics and mechanotransduction: pathways, probes, and physiology. AJP: Cell Physiology, 287(1):C1–C11, February 2004.

    Article  CAS  Google Scholar 

  • Jinghuan Huang, Stefan V Grater, Francesca Corbellinl, Sabine Rinck, Eva Bock, Ralf Kemkemer, Horst Kessler, Jiandong Ding, and Joachim P Spatz. Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion. Nano Letters, 9(3):1111–1116, January 2009.

    Article  CAS  Google Scholar 

  • Paul A Janmey. The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiological Reviews, 78(3):763–781, July 1998.

    CAS  Google Scholar 

  • Simon Jungbauer, Huajian Gao, Joachim P Spatz, and Ralf Kemkemer. Two Characteristic Regimes in Frequency-Dependent Dynamic Reorientation of Fibroblasts on Cyclically Stretched Substrates. Biophysical Journal, 95(7):3470–3478, October 2008.

    Article  CAS  Google Scholar 

  • Torsten Kühne, Reinhard Lipowsky, and Jan Kierfeld. Zipping mechanism for force generation by growing filament bundles. Europhysics Letters, 86(6):68002, 2009.

    Article  Google Scholar 

  • Theobald Lohmüller, Daniel Aydin, Marco Schwieder, Christoph Morhard, Ilia Louban, Claudia Pacholski, and Joachim P Spatz. Nanopatterning by block copolymer micelle nanolithography and bioinspired applications. Biointerphases, 6(1):MR1, 2011.

    Article  Google Scholar 

  • Shingo Miyamoto, Steven K Akiyama, and Kenneth M Yamada. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science, 267(5199):883–885, February 1995.

    Article  CAS  Google Scholar 

  • Alexander Mogilner and Boris Rubinstein. The physics of filopodial protrusion. Biophysical Journal, 89(2):782–95, 2005.

    Article  CAS  Google Scholar 

  • Rajalakshmi Nambiar, Russell McConnell, and Matthew Tyska. Myosin motor function: the ins and outs of actin-based membrane protrusions. Cellular and Molecular Life Sciences, 67(8):1239–54, 2010.

    Article  CAS  Google Scholar 

  • Charles Peskin, Garret Odell, and George Oster. Cellular motions and thermal fluctuations: the Brownian ratchet. Biophysical Journal, 65(1): 316–324, 1993.

    Article  CAS  Google Scholar 

  • Sander Pronk, Phillip Geissler, and Daniel Fletcher. Limits of Filopodium Stability. Physical Review Letters, 100(25):4–7, 2008.

    Article  Google Scholar 

  • Erkki Ruoslahti and Michael D Pierschbacher. New Perspectives in Cell-Adhesion - RGD and Integrins. Science, 238(4826):491–497, 1987. Joachim P Spatz, Stefan Mössmer, Christoph Hartmann, Martin Möller, Thomas Herzog, Michael Krieger, Hans-Gerd Boyen, Paul Ziemann, and Bernd Kabius. Ordered Deposition of Inorganic Clusters from Micellar Block Copolymer Films. Langmuir, 16(2):407–415, January 2000.

    Google Scholar 

  • Martin Streichfuss, Friedrich Erbs, Kai Uhrig, and Rainer Kurre. Measuring Forces between Two Single Actin Filaments during Bundle Formation. Nano Letters, 11(9):3676–80, September 2011.

    Article  CAS  Google Scholar 

  • Tatyana Svitkina, Elena Bulanova, and Oleg Chaga. Mechanism of filopodia initiation by reorganization of a dendritic network. The Journal of Cell Biology, 160:409–421, 2003.

    Article  CAS  Google Scholar 

  • Manuel Théry, Anne Pépin, Emilie Dressaire, Yong Chen, and Michel Bornens. Cell distribution of stress fibres in response to the geometry of the adhesive environment. Cell Motility and the Cytoskeleton, 63(6): 341–355, June 2006.

    Article  Google Scholar 

  • Kai Uhrig, Rainer Kurre, Christian Schmitz, Jennifer E Curtis, Tamás Haraszti, Anabel E-M Clemen, and Joachim P Spatz. Optical force sensor array in a microfluidic device based on holographic optical tweezers. Lab on a chip, 9(5):661–8, March 2009.

    Article  CAS  Google Scholar 

  • Eli Zamir and Benjamin Geiger. Molecular complexity and dynamics of cell-matrix adhesions. Journal of Cell Science, 114(20):3583–3590, 2001.

    CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Biophysical Chemistry, University of Heidelberg, Heidelberg, Germany

    Claire M. Cobley, Seraphine V. Wegner, Martin Streichfuss & Joachim P. Spatz

  2. Department of New Materials and Biosystems, Max-Planck-Institute for Intelligent Systems, Stuttgart, Germany

    Claire M. Cobley, Seraphine V. Wegner, Martin Streichfuss & Joachim P. Spatz

Authors
  1. Claire M. Cobley
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  2. Seraphine V. Wegner
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  3. Martin Streichfuss
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  4. Joachim P. Spatz
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Editor information

Editors and Affiliations

  1. Civil and Environmental Department, Massachusetts Institute of Technology, Cambridge, MA, USA

    Markus J. Buehler

  2. Department of Civil Engineering, University of Minnesota, Minneapolis, MN, USA

    Roberto Ballarini

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Cobley, C.M., Wegner, S.V., Streichfuss, M., Spatz, J.P. (2013). Advances in Experimental Cell Biology and Cell-Material Interactions. In: Buehler, M.J., Ballarini, R. (eds) Materiomics: Multiscale Mechanics of Biological Materials and Structures. CISM International Centre for Mechanical Sciences, vol 546. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1574-9_5

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  • DOI: https://doi.org/10.1007/978-3-7091-1574-9_5

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-1573-2

  • Online ISBN: 978-3-7091-1574-9

  • eBook Packages: EngineeringEngineering (R0)

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