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Animal Models of Atherosclerosis

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Inflammation and Atherosclerosis

Abstract

In humans, the causal mechanisms behind the development of atherosclerosis are still not fully understood. On the one hand, the disease process is multifactorial in its initiation and complex because of its chronic nature; on the other, it has not been possible to sequentially characterize lesions in an individual patient, despite rapid progress in non-invasive detection modalities. Furthermore, for ethical reasons, experimental studies of atherosclerosis in patients with cardiovascular disease cannot be conducted. Thus, there arose the necessity to develop appropriate animal models in which both ex vivo and in vivo experimentations can be performed, and which would help delineate the pathogenetic steps and causal relations in this disease. During the last century, numerous different animal species, from mice to monkeys, have been used to study the pathogenesis of atherosclerotic lesions and their potential treatment. In this chapter, we will recapitulate and summarize the most important rabbit, rat, and mice models used in experimental studies of atherogenesis (see Fig. 8.1).

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  1. Laboratory of Autoimmunity, Division of Experimental Pathophysiology and Immunology, Biocenter, Innsbruck Medical University, Schöpfstraße 41, A-6020, Innsbruck, Austria

    Cecilia Grundtman

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  1. Medical University Innsbruck, Peter-Mayr-Strasse 4 a, Innsbruck, 6020, Austria

    Georg Wick

  2. Laboratory of Autoimmunity, Division of Experimental Pathophysiology, Biocenter, Innsbruck Medical University, Schöpfstraße 41, Innsbruck, 6020, Austria

    Cecilia Grundtman

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Grundtman, C. (2012). Animal Models of Atherosclerosis. In: Wick, G., Grundtman, C. (eds) Inflammation and Atherosclerosis. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0338-8_8

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