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Cytokine-Mediated Enhancement of Host Defense

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1997

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1997))

  • 131 Accesses

Abstract

Despite prompt antibiotic treatment of microbial infections and aggressive intensive care of the critically ill, progression to the septic shock syndrome remains common and mortality still exceeds 50% [1, 2]. This situation has promoted the distinction between infections as microbiological phenomena, and septic shock as a complex series of deleterious host responses to such microbial invasion [1, 3]. Two factors have been important in shaping the current widely-held conception that these host-derived inflammatory responses are stereotypically activated in infected subjects regardless of the type of pathogen. The first may be termed an argument based on the clinical equivalency of pathogen-specific sepsis. Physiologic and metabolic derangements during severe infection by taxonomically diverse organisms (e.g. Gram-negative bacteria, Gram-positive bacteria, pathogenic fungi, rickettsiae, and viruses) often are clinically indistinguishable [3–5]. Thus, the inflammatory events responsible for these clinical derangements are thought to be similar. Initially manifested by the systemic inflammatory response syndrome (SIRS), these events lead to circulatory instability with respiratory distress according to the extent of infection and/or the intensity of the host response, culminating in multiple organ failure (MOF) [1,2].

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Authors
  1. A. J. Lechner
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  2. G. M. Matuschak
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1997 Springer-Verlag Berlin Heidelberg

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Lechner, A.J., Matuschak, G.M. (1997). Cytokine-Mediated Enhancement of Host Defense. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1997. Yearbook of Intensive Care and Emergency Medicine, vol 1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13450-4_11

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  • DOI: https://doi.org/10.1007/978-3-662-13450-4_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-13452-8

  • Online ISBN: 978-3-662-13450-4

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