Abstract
In studies of hypothalamic regulation of pituitary function the interest has mainly been focussed on two classes of substances: the hypothalamic releasing and inhibiting factors (which are peptides) and the biogenic monoamines. There is now much experimental evidence that catecholamines (CA) participate importantly in the regulation of the release of hypothalamic hormones (see Lichtensteiger, 1970; McCann et al., 1972; Hökfelt and Fuxe, 1972; Porter et al., 1972 for reviews) and special attention has been devoted to the role of CAs in the function of the median eminence. This was initiated by the observations by Carlsson et al. (1962) and by Fuxe (1963, 1964) of a massive supply of CA fibres to the median eminence of various mammalian species. In later studies, Fuxe and Hökfelt (1966) and Lichtensteiger and Langemann (1966) provided evidence in the rat and mouse that at least part of this innervation originated in the arcuate nuclei, constituting a tubero-infundibular CA (probably DA-containing) system. It soon became clear, however, that the CA innervation of the infundibular region is very complex and since it was felt that a detailed neuroanatomical knowledge would be indispensable for correct interpretations of functional and experimental data, a series of studies has been carried out in our laboratory, aiming at a more detailed picture of the topography and organization of the dopamine (DA) and noradrenaline (NA) producing neurons innervating the pituitary-median eminence complex.
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Björklund, A., Falck, B., Nobin, A., Stenevi, U. (1974). Organization of the Dopamine and Noradrenaline Innervations of the Median Eminence-Pituitary Region in the Rat. In: Knowles, F., Vollrath, L. (eds) Neurosecretion — The Final Neuroendocrine Pathway. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-12587-8_22
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