Abstract
A lymphoma of African children, described as a distinct clinical entity by Burkitt in 1958 (1), has aroused considerable interest because epidemiological evidence strongly suggests that an external environmental factor is involved, possibly a vector- borne virus disease. Burkitt’s tumor occurs in high incidence in those regions of Africa where climatic conditions are favorable for the dissemination of arthropod- vectored agents (2, 3). A high incidence of the tumor, but not the geographic and climatic limitations noted in Africa, has also been observed in New Guinea (4). Cases in Africa are infrequent among adults residing in endemic areas. However, among immigrants from regions where the tumor is rare, nearly 50 percent were over 15 years of age. Racial and tribal characteristics have been said to be of no significance in susceptibility to tumor development. These observations suggest that immunity develops in most persons exposed to the inciting agent and may be a factor in the response of patients to therapy (5).
National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare.
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Manaker, R.A. (1969). Viruses Associated with Burkitt’s Lymphoma. In: Mizell, M. (eds) Biology of Amphibian Tumors. Recent Results in Cancer Research, vol 1969. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85791-1_40
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