Abstract
In clinical practice hyperthermia should enhance the cytotoxic effects of other cancer therapy modalities on tumors while not increasing side-effects on normal tissues. Interactions between hyperthermia and cytostatic drugs (Hahn 1982; Honess and Bleehen 1985; Neumann et al. 1985) on malignant cell lines or in experimental tumor models are well known, but only a few studies have been performed with defined treatment regimens in normal tissues (Overgaard and Suit 1979), especially in critical organs. In order to elucidate various toxic effects induced by combined therapy involving moderate whole-body hyperthermia (mWBH) and cytostatic drugs (thermochemotherapy, TCT) we examined specific side-effects of doxorubicin and/or mWBH.
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References
Bristow MR, Mason JW, Billingham ME, Daniels JR (1981) Dose effect and structure function relationships in doxorubicin cardiomyopathy. Am Heart J 102: 709–718
Doroshow JH, Locker GJ, Myers CE (1979) Experimental animal models of adriamycin cardiotoxicity. Cancer Treat Rep 63: 855–860
Engelhardt R (1983) Clinical trials on thermo-chemotherapy (TCT), TCT in small cell carcinoma of the lung. Strahlentherapie 159: 371–372
Hahn GM (1982) Thermal enhancement of the actions of anticancer agents. In: Hahn GM (ed) Hyperthermia and cancer. Plenum, New York, pp 55–86
Honess DJ, Bleehen NM (1985) Potentiation of mephalan by systemic hyperthermia in mice: therapeutic gain for mouse lung microtumours. Int J Hyperthermia 1: 57–68
Neumann HA, Fiebig HH, Löhr GW, Engelhardt R (1985) Effects of cytostatic drugs and 40.5° C hyperthermia on human clonogenic tumor cells. Eur J Cancer Clin Oncol 21: 515–523
Overgaard J (1983) Histopathologic effects of hyperthermia. In: Storm FK (ed) Hyperthermia in cancer therapy. Hall, Boston, pp 163–164
Overgaard J, Suit HD (1979) Time-temperature relationship in hyperthermic treatment of malignant and normal tissue in vivo. Cancer Res 39: 3248–3253
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© 1988 Springer-Verlag Berlin Heidelberg
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Birmelin, M., Hinkelbein, W., Oehlert, W., Wannenmacher, M. (1988). Cardiotoxicity of Moderate Whole-Body Hyperthermia, Doxorubicin, and Combined Treatment in Rats. In: Hinkelbein, W., Bruggmoser, G., Engelhardt, R., Wannenmacher, M. (eds) Preclinical Hyperthermia. Recent Results in Cancer Research, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83263-5_11
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DOI: https://doi.org/10.1007/978-3-642-83263-5_11
Publisher Name: Springer, Berlin, Heidelberg
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