Abstract
This variety of leukemia is usually associated with the middle-aged and with young adults. It is not a common disease at any age but the incidence is actually greatest in old age, rising after age 70 and stabilizing at 13–14 per 100,000 per year in the eighties and beyond, as shown in Fig. 17.1. It is equally common in men and women. Fatigue, sweating, and abdominal fullness cause these patients to seek medical attention. Splenomegaly and very high blood granulocyte counts strongly suggest this diagnosis. However, in 1965 Conrad et al. made the point that presentation of this disease in the elderly may be atypical. The relationship of chronic myelocytic leukemia to the other entities in the myeloproliferative syndrome — polycythemia vera, agnogenic myeloid metaplasia, myelofibrosis, acute myelocytic leukemia — is not at all clear.
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References
Conrad ME, Rappaport H, Crosby WH (1965) Chronic granulocytic leukemia in the aged. Arch Intern Med 116:765–775
Fefer A, Cheever MA, Thomas ED, Boyd C, Ramberg R, Glucksberg H, Buckner CD, Storb R (1979) Disappearance of Ph1-positive cells in four patients with chronic granulocytic leukemia after chemotherapy, irradiation and marrow transplantation from an identical twin. N Engl J Med 300:333–337
Goldman JM, Johnson SA, Catovsky D, Wareham NJ, Galton DAG (1981) Autografting for chronic phase of chronic granulocytic leukemia. N Engl J Med 305:700
Ihde DC, Canellos GP, Schwartz JH, De Vita VT (1976) Splenectomy in the chronic phase of chronic granulocytic leukemia. Ann Intern Med 84:17–21
Koeffler HP, Gode DW (1981) Chronic myelogenous leukemia — new concepts. N Engl J Med 304:1201–1209, 1269–1274
Spiers ASD, Baikie AG, Galton DAG, Richards HGH, Wiltshaw E, Goldman JM, Catovsky D, Spencer J, Peto R (1975) Chronic granulocytic leukemia: effect of elective splenectomy on the course of disease. Br Med J 1:175–179
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© 1983 Springer-Verlag Berlin Heidelberg
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Holmes, F.F. (1983). Chronic Myelocytic Leukemia. In: Aging and Cancer. Recent Results in Cancer Research, vol 87. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82101-1_17
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DOI: https://doi.org/10.1007/978-3-642-82101-1_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-82103-5
Online ISBN: 978-3-642-82101-1
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