Skip to main content
SpringerLink
Log in

Differentiation of Tumor Cells

Induction of Erythrocyte Membrane-Specific Antigens in Friend Leukemia Cells

  • Chapter
Special Topics in Carcinogenesis

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 44))

Abstract

It was believed for a long time, in both experimental and clinical fields that every cancer had its own malignancy and progressed into a more malignant state after a certain period. In other words, the cancer phenotype was stable and if it changed, it progressed only towards a more malignant state. Cancerization was thought to be irreversible. Ten years ago, Yoshida et al. [43] concluded that an irreversible change in a benign direction can very rarely occur in tumor cells. In viral carcinogenesis in vitro, Macpherson [25] demonstrated a revertant colony derived from cloned transformed cells. Braun [4] discussed the reversal of tumor growth from the viewpoint of gene regulation. Recently, Sugimura [40] also stressed a certain phenotypic change of a tumor as “decarcinogenesis” in his enzymic study of tumors. In the clinical field, as Everson and Cole [6] noted, spontaneous regression of human cancer definitely occurs.

This study was partly supported by a Grant-in-Aid from the Ministry of Education, and the Ministry of Health and Welfare, Government of Japan.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adachi, H., Furusawa, M.: Exp. Cell Res. 50, 490 (1968).

    Article  PubMed  CAS  Google Scholar 

  2. Biedler, J. L., Riehm, H.: Proc. Amer. Ass. Cancer Res. 11, 30 (1970).

    Google Scholar 

  3. Blume, A., Gilbert, F., Wilson, S., Farber, J., Rosenberg, R., Nierenberg, M.: Proc. nat. Acad. Sci. (Wash.) 67, 786 (1970).

    Article  CAS  Google Scholar 

  4. Braun, A. C.: The cancer problem. New York, London: Columbia Univ. Press 1969.

    Google Scholar 

  5. Burger, M. M., Noonan, K. D.: Nature (Lond.) 228, 512 (1970).

    Article  CAS  Google Scholar 

  6. Everson, T. C., Cole, W. H.: Spontaneous regression of cancer. Philadelphia, London: W. B. Saunders 1966.

    Google Scholar 

  7. Friend, C.: J. exp. Med. 105, 307 (1957).

    Article  PubMed  CAS  Google Scholar 

  8. Friend, C., Patuleia, M. C., de Harven, E.: Nat. Inst. Monogr. 22, 505 (1966).

    CAS  Google Scholar 

  9. Friend, C., Scher, W., Holland, J. G., Sato, T.: Proc. nat. Acad. Sci. (Wash.) 68, 378 (1971).

    CAS  Google Scholar 

  10. Furusawa, M., Adachi, H.: Exp. Cell. Res. 50, 497 (1968).

    Article  PubMed  CAS  Google Scholar 

  11. Furusawa, M., Ikawa, Y., Sugano, H.: Proc. Jap. Acad. 47, 220 (1971).

    CAS  Google Scholar 

  12. Furusawa, M., Takahashi, K. P.: Nature (Lond.) (in press) (1972).

    Google Scholar 

  13. Furusawa, M., Ikawa, Y., Sugano, H.: GANN Monogr. Cancer Res. 12, 123 (1972).

    Google Scholar 

  14. Gallo, R. C., Yang, S. S., Ting, R. C.: Nature (Lond.) 228, 927 (1970).

    Article  CAS  Google Scholar 

  15. Gurgo, C., Ray, R. K., Thiry, L., Green, M.: Nature (Lond.) New Biol. 229, 111 (1971)

    Article  CAS  Google Scholar 

  16. Harris, H., Miller, O. J., Klein, G., Worst, P., Tachibana, T.: Nature (Lond.) 223, 363 (1969).

    Article  CAS  Google Scholar 

  17. Ichikawa, Y.: J. cell. comp. Physiol. 76, 175 (1970).

    CAS  Google Scholar 

  18. Ikawa, Y., Sugano, H.: GANN 57, 641 (1966).

    PubMed  CAS  Google Scholar 

  19. Ikawa, Y., Sugano, H.: Trans. Soc. path. Jap. 55, 139 (1966).

    Google Scholar 

  20. Ikawa, Y., Sugano, H., Furusawa, M.: GANN Monogr. Cancer Res. 12, 29 (1972).

    Google Scholar 

  21. Johnson, G. S., Friedman, R. M., Paston, I.: Proc. nat. Acad. Sci. (Wash.) 68, 425 (1971).

    Article  CAS  Google Scholar 

  22. Kates, J. R., Winterton, R., Schlessinger, K.: Nature (Lond.) 229, 345 (1971).

    Article  CAS  Google Scholar 

  23. Kasuga, T.: Proc. Jap. Cancer Ass. (26th Ann. Meeting), p. 223 (1966).

    Google Scholar 

  24. Koyama, K., Ishii, K.: GANN 60, 367 (1969).

    PubMed  CAS  Google Scholar 

  25. Macpherson, I.: Science 148, 1731 (1965).

    Article  PubMed  CAS  Google Scholar 

  26. Patuleia, M. C., Friend, C.: Cancer Res. 27, 726 (1967).

    Google Scholar 

  27. Pollack, R., Green, H., Todaro, G.: Proc. nat. Acad. Sci. (Wash.) 60, 126 (1968).

    Article  CAS  Google Scholar 

  28. Rabinowitz, A., Sachs, L.: Virology 40, 193 (1970).

    Article  PubMed  CAS  Google Scholar 

  29. Rossi, G. B., Friend, C.: Proc. nat. Acad. Sci. (Wash.) 58, 1373 (1967).

    Article  CAS  Google Scholar 

  30. Rothchild, H., Black, P. H.: Proc. nat. Acad. Sci. (Wash.) 67, 1042 (1970).

    Article  Google Scholar 

  31. Sanders, F. K., Burford, B. O.: Nature (Lond.) 220, 448 (1968).

    Article  CAS  Google Scholar 

  32. Sassa, S., Takaku, F., Nakao, K., Ikawa, Y., Sugano, H.: Proc. exp. biol. Med. 127. 527 (1968).

    CAS  Google Scholar 

  33. Sato, S., Matsushima, T., Sugimura, T.: Cancer Res. 29, 1437 (1969).

    PubMed  CAS  Google Scholar 

  34. Sato, T., Friend, C., de Harven, E.: Cancer Res. 31, 1402 (1971).

    PubMed  CAS  Google Scholar 

  35. Schubert, D., Jacob, F.: Proc. nat. Acad. Sci. (Wash.) 67, 247 (1970).

    Article  CAS  Google Scholar 

  36. Silagi, S., Bruce, S. A.: Proc. nat. Acad. Sci. (Wash.) 66, 72 (1970).

    Article  CAS  Google Scholar 

  37. Soule, H. D., Albert, S., Wolf, P. L., Stansly, P. G.: Exp. Cell Res. 42, 380 (1966).

    Article  PubMed  CAS  Google Scholar 

  38. Sugano, H., Furusawa, M., Kawaguchi, T., Ikawa, Y.: 5th Intl. Symp. Comparative Leukemia Res., Padova (1971), Bibi, haemat. 39, 943 (Karger: Basel 1973).

    Google Scholar 

  39. Sugano, H., Furusawa, M., Kawaguchi, T., Ikawa, Y.: (in preparation).

    Google Scholar 

  40. Sugimura, T.: Chemical Tumor Problems. Ed. W. Nakahara. Tokyo: Jap. Soc. for the Promotion of Sci. 1970, pp. 269–284.

    Google Scholar 

  41. Umezawa, H., Ishizuka, M., Kimura, K., Iwanaga, J., Takeuchi, T.: J. Antibiot. (Tokyo) 21, 592 (1968).

    CAS  Google Scholar 

  42. Utakoji, T.: (personal communication).

    Google Scholar 

  43. Yoshida, T.: Meth. Cancer Res. 6, 97 (1971).

    CAS  Google Scholar 

Download references

Authors
  1. H. Sugano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Furusawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Kawaguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Ikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Pathologisches Institut der Universität, D 4400, Münster, Westring 17, Germany

    E. Grundmann

Additional information

We thank Mr. T. Nashiro for his skilful assistance in electron microscopy.

Rights and permissions

Reprints and permissions

Copyright information

© 1973 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Sugano, H., Furusawa, M., Kawaguchi, T., Ikawa, Y. (1973). Differentiation of Tumor Cells. In: Grundmann, E. (eds) Special Topics in Carcinogenesis. Recent Results in Cancer Research, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80786-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80786-2_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80788-6

  • Online ISBN: 978-3-642-80786-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation