Skip to main content

Carcinoma of the Prostate: Science and Treatment

  • Conference paper
Progress in Diagnostics and Therapy of Prostatic Cancer
  • 44 Accesses

Abstract

Carcinoma of the prostate is the second most common cause of cancer in men and its incidence has virtually doubled over the last 30 years.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Beland G, Elhilali M, Fradet Y et al. (1990) Randomized study comparing orchiectomy versus orchiectomy and anandron in advanced prostate cancer. Gynecol Endocrinol 4 [Suppl 2]: 81

    Google Scholar 

  • Bertagna C (1990) Treatment of metastatic prostate cancer with orchiectomy and anandron R (Nilutamide): results of a double-blind study versus orchiectomy and placebo. Gynecol Endocrinol 4 [Suppl 2]: 82

    Google Scholar 

  • Blackard CE, Byar DP, Jordan WP, Vacurg (1973) Orchiectomy for advanced prostatic carcinoma. Urology 1 (6): 553

    Article  PubMed  CAS  Google Scholar 

  • Boccardo F (1990) Treatment of prostatic cancer with LH-RH analogues alone or in combination with pure antiandrogens. Gynecol Endocrinol 4 [Suppl 2]: 84

    Google Scholar 

  • Bookstein R, Shew JY, Chen PL, Scully P, Lee WH (1990) Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science 247: 712

    Article  PubMed  CAS  Google Scholar 

  • Carter BS, Epstein JI, Isaacs WB (1990) ras Gene mutations in human prostate cancer. Cancer Res 50: 6830

    Google Scholar 

  • Crawford ED, Eisenberger MA, McLeod DG et al. (1989) A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med 321 (7): 419

    Article  PubMed  CAS  Google Scholar 

  • Crawford ED, Bertagna C, Smith JA et al. (1990) A randomized, controlled clinical trial of leuprolide and anandron versus leuprolide and placebo for advanced prostate cancer. Gynecol Endocrinol 4 [Suppl 2]: 85

    Article  Google Scholar 

  • De Voogt HJ, Klijn JG, Studer U, Schroeder FG, Sylvester R, de Pauw M, members of the EORTC-GU Group (1990) Comparison of orchidectomy and buserelin combined with anti androgens in the treatment of advanced prostatic cancer. (EORTC-trial 30843). Gynecol Endocrinol 4 [Suppl 2]: 83

    Google Scholar 

  • Ferrari P, Castagnetti G, Pollastri C, Ferrari G, Tavoni F, Grassi D (1990) LHRH analogue buserelin versus buserelin and flutamide in the treatment of advanced metastatic prostatic carcinoma. Five Years Experience. Gynecol Endocrinol 4 [Suppl 2]: 87

    Google Scholar 

  • Fleming WH, Hamel A, MacDonald R et al. (1986) Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia. Cancer Res 46: 1535

    PubMed  CAS  Google Scholar 

  • Fourcade O, Carion G, Coloby P, Grise P, Mang P, Soret J, Poteri M (1990) Total androgen blockade in advanced prostate carcinoma: interim report of a double blind study using Zoladex and flutamide. Gynecol Endocrinol 4 [Suppl 4]: 89

    Google Scholar 

  • Fowler JE Jr, Lau JLT, Ghosh L, Mills SE, Mounzer A (1988) Epidermal growth factor and prostatic carcinoma: an immunohistochemical study. J Urol 139: 857

    PubMed  Google Scholar 

  • Haefliger JM (1990) A multicentre randomised trial comparing the LHRH analogue ‘zoladex’ vs ‘zoladex’ in combination with flutamide in the treatment of advanced prostate cancer. Gynecol. Endocrinol. 4 [Suppl 2]: 88

    Google Scholar 

  • Huggins C, Hodges CV (1941) The effect of castration, of estrogen, and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1: 292

    Google Scholar 

  • Iversen P, Danish Prostatic Cancer Group (1990) Daproca 86-zoladex and flutamide versus orchiectomy for avanced prostatic cancer. Gynecol Endocrinol 4 [Suppl 2]: 88

    Google Scholar 

  • Labrie F, Dupont A, Giguere M et al. (1987) Combination therapy with flutamide and castration (orchiectomy or LHRH agonist): the minimal endocrine therapy in both untreated and previously treated patients. J Steroid Biochem 27 (1–3): 525

    Article  PubMed  CAS  Google Scholar 

  • Lunglmayr G (1989) Casodex (ICI 176, 334), a new, non-steroidal anti-androgen. Early clinical results. Horm Res 32 [Suppl 1]: 77

    Google Scholar 

  • MacDonald A, Chisholm GD, Habib FK (1990) Production and response of a human prostatic cancer line to transforming growth factor-like molecules. Br J Cancer 62: 579

    Article  PubMed  CAS  Google Scholar 

  • Mahler C, Pinto de Carvalho A, Smith P, members of the EORTC GU Group (1990) Randomized study of orchiectomy versus zoladex and flutamide in metastatic prostatic cancer. Gynecol Endocrinol 4 [Suppl 2]: 81

    Google Scholar 

  • Morris GL, Green Dodd J (1990) Epidermal growth factor receptor mRNA levels in human prostatic tumors and cell lines. J Urol 143: 1272

    PubMed  CAS  Google Scholar 

  • Neri R, Kassem N (1984) Biological and clinical properties of antiandrogens. In: Bresciani F, King RJB, Lippmann ME, Namer M, Raynaud JP (eds) Hormones and cancer 2: Proceedings of the 2nd international congress on hormones and cancer. Raven, New York, p 507 (Progress in cancer research and therapy, vol 31)

    Google Scholar 

  • Nesbit RM, Baum WC (1950) Endocrine control of prostatic carcinoma: clinical and statistical survey of 1818 cases. JAMA 143: 1317

    Article  CAS  Google Scholar 

  • Osborne CK, Blumenstein B, Crawford ED et al. (1990) Combined versus sequential chemo-endocrine therapy in advanced prostate cancer: final results of a randomized Southwest Oncology Group Study. J Clin Oncol 8: 1675

    PubMed  CAS  Google Scholar 

  • Pavone-MacAluso M, De Voogt HJ, Viggiano G et al. (1986). Comparison of diethystilbestrol, cyproterone acetate and medroxyprogesterone acetate in the treatment of advanced prostatic cancer: final analysis of a randomized phase III trial of the European Organization For Research On Treatment Of Cancer Urological Group. J Urol 136: 624

    PubMed  CAS  Google Scholar 

  • Plowman PN, Perry LA, Chard T (1987) Androgen suppression by hydrocortisone without ami-noglutethimide in orchiectomised men with prostatic cancer. Br J Urol 59: 255

    Article  PubMed  CAS  Google Scholar 

  • Qayum A, Gullick W, Clayton RC, Sikora K, Waxman J (1990) The effects of gonadotrophin releasing hormone analogues in prostate cancer are mediated through specific tumor receptors. Br J Cancer 62: 96

    Article  PubMed  CAS  Google Scholar 

  • Rijinders AWM, Van der Korput JAGM, Van Steenbrugge GJ, Romijn JC, Trapman J (1985) Expression of cellular oncogenes in human prostatic carcinoma cell lines. Biochem Biophys Res Commun 132 (2): 548

    Article  Google Scholar 

  • Sogani PC, Ray B, Whitmore WF Jr. (1975) Advanced prostatic carcinoma. Urology VI: 164

    Article  Google Scholar 

  • Trachtenberg T, Walsh PC (1982) Correlation of prostatic nuclear androgen receptor content with duration of response and survival following hormonal therapy in advanced prostatic cancer. J Urol 127: 466

    PubMed  CAS  Google Scholar 

  • Treiger B, Isaacs J (1988) Expression of a transfected v-Harvey-ras oncogene in a Dunning rat prostate adenocarcinoma and the development of high metastatic ability. J Urol 140: 1580

    PubMed  CAS  Google Scholar 

  • Veterans Administration Cooperative Urological Research Group (1967) Treatment and survival of patients with cancer of the prostate. Surg Gynecol Obstet 124: 1011

    Google Scholar 

  • Viola V, Fromowitz F, Oravez S et al. (1986) Expression of ras oncogene p21 in prostate cancer. N Engl J Med 314: 133

    Article  PubMed  CAS  Google Scholar 

  • Waxman J (1987) Gonadotrophin hormone releasing analogues open new doors in cancer treatment. Br Med J 295: 1084

    Article  CAS  Google Scholar 

  • Waxman J, Williams G, Sandow J et al. (1988) The clinical and endocrine assessment of three different antiandrogen regimens combined with a very long-acting gonadotrophin-releasing hormone analogue. Am J Clin Oncol II [Suppl 2]: 152

    Article  Google Scholar 

  • Waxman J, Sandow J, Abel P, Barton C, Keane P, Williams G (1990) Three-monthly GnRH agonist (Buserelin) for prostatic cancer: Br J Urol 65: 43

    Article  PubMed  CAS  Google Scholar 

  • White JW (1893) The present position of the surgery of the hypertrophied prostate. Ann Surg 18: 152

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Waxman, J. (1996). Carcinoma of the Prostate: Science and Treatment. In: Peeling, W.B., Becker, H. (eds) Progress in Diagnostics and Therapy of Prostatic Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79947-1_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79947-1_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60195-1

  • Online ISBN: 978-3-642-79947-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics