Abstract
Rheumatoid factors, a useful diagnostic aid for rheumatoid arthritis, have come a long way since their discovery in 1937 by Erik Waaler (Waaler 1940). Exciting new information is revealing that rheumatoid factors are generated from a limited set of germ line genes. Most detailed studies on rheumatoid factor utilize immunoglobulins from disease in which there is a malignant proliferation of rheumatoid factor producing cells as in chronic lymphocytic leukemia or where there is a benign proliferation of a lymphoid clone. Increasingly, it appears that a limited number of clones are used in rheumatoid arthritis as well, but that they may be somatically mutated to give a limited degree of oligoclonality (Shlomchik et al. 1987).
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References
Andrew DW, Capra JD (1981) Complete amino acid sequence of variable domains from two monoclonal human anti-gamma-globulins of the Wa cross idiotypic group. Suggestion that the J segments are involved in structural correlates of the idiotype. Proc Natl Acad Sci USA 783: 799
Geysen HM, Rodda SJ, Mason TJ, Tribbick G, Schoofs PG (1987) Strategies for epitope analysis using peptide synthesis. J Immunol Methods 102: 259
Goni F, Chen PP, Pons-Estel B, Carson DA, Frangione B (1985) Sequence similarities and cross-idiotypic specificity of L chains among human monoclonal IgMk with anti-y-globulin activity. J Immuno1 135:4073
Hay FC (1988) Rheumatoid factor structural and genetic studies indicating novel binding sites may confer the specificity for IgG Fe. Br J Rheumatol 27 (Suppl II): 157
Kunkel H, Agnello V, Joslin FG, Winchester RJ, Capra JD (1973) Cross-idiotypic specificity among monoclonal IgM proteins with anti-gamma-globulin activity. J Exp Med 137: 331
Ledford DK, Goni F, Pizzolato M, Franklin EC, Solomon A, Frangione B (1983) Preferential association of kIIIb light chains with monoclonal human IgMk autoantibodies. J Immunol 131: 1322
Moynihan JA, Looney RJ, Abraham GN (1985) The VkIIIB light chain sub-group restricted association with mu heavy chains in normal human serum. Immunology 54: 207
Pons-Estel B, Goni F, Solomon A, Frangione B (1984) Sequence similarities among kIIIb light chains of monoclonal human IgMk autoantibodies. J Exp Med 160: 893
Shlomchik MJ, Marshak-Rothstein A, Wolfowicz CB, Rothstein TL, Weigert MG (1987) The role of clonal selection and somatic mutation in autoimmunity. Nature (London) 328: 805
Shlomchik MJ, Nemazee DA, Sato VI, van Snick J, Garson DA, Weigert MG (1986) Variable region sequences of murinea IgG anti-IgG monoclonal autiantibodies (rheumatoid factor) J Exp Med 164: 407
Thompson KM, Randen I, Natvig JB, Mageed RM, Jefferis R, Carson DA, Tighe H, Forre 0 (1990) Human monoclonal rheumatoid factors derived from the polyclonal repertoire of rheumatoid synovial tissue incidence of cross-reactive idiotypes and expression of Vu and V subgroups. Eur J Immunol 20: 863
Waaler E (1940) On the occurence of a factor in human serum activating the specific agglutination of sheep blood corpuscles. Acta Pathol Microbiol Scand 17: 172
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© 1991 Springer-Verlag Berlin Heidelberg
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Hay, F.C., Soltys, A.J., Tribbic, G., Geysen, H.M. (1991). The Significance of IgG Peptides and Sugars for the Development of Autoimmunity in Rheumatoid Arthritis. In: Vaheri, A., Tilton, R.C., Balows, A. (eds) Rapid Methods and Automation in Microbiology and Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76603-9_14
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DOI: https://doi.org/10.1007/978-3-642-76603-9_14
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