Abstract
Radiotherapy (RT) is, with surgery, one of the two main methods for the locoregional treatment of cancer. Its modern era started in 1920, when Regaud showed that with proper fractionation it was possible to reduce the toxic effects of radiation on normal tissue without a correspondingly large loss of therapeutic effect on the tumor. This differential effect takes advantage of the strong regulatory mechanisms that exist in normal tissues. The roles of the dose per fraction (fractionation) and of the overall duration of the radiotherapy course (protraction) have recently been further elucidated (Tubiana et al. th 1986 b; Fowler 1984).
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© 1989 Springer-Verlag Berlin Heidelberg
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Tubiana, M. (1989). Irradiation in Cancer Treatment. In: Veronesi, U., Arnesjø, B., Burn, I., Denis, L., Mazzeo, F. (eds) Surgical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72646-0_13
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DOI: https://doi.org/10.1007/978-3-642-72646-0_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72648-4
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