Skip to main content

Granulosa Cell Tumor, Ovary, Mouse

  • Chapter
Genital System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Granulosa cell tumors may be up to 3 cm in diameter. Small tumors may only be detected by microscopic examination. Benign tumors are encapsulated, often nodular, solid or cystic, and gray to yellow. Malignent tumors are larger, are pink in color, and frequently contain hemorrhagic cysts. Those malignant tumors composed of multiple small nodules are often contained within the ovarian bursa.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alison RH, Morgan KT, Haseman JK, Boorman GA (1987) Morphology and classification of ovarian neoplasms in F344 rats and B6C3F1 mice. To be published

    Google Scholar 

  • Bauminger S, Webb C, Okon E (1979) Characterization of a spontaneous granulosa cell tumor in SWR mice. Cancer Treat Rep 63:1178

    Google Scholar 

  • Beamer WG, Hoppe PC, Whitten WK (1985) Spontaneous malignant granulosa cell tumors in ovaries of young SWR mice. Cancer Res 45: 5575–5581

    PubMed  CAS  Google Scholar 

  • Bielschowsky M, d’Ath EF (1973) Spontaneous granulosa cell tumours in mice of strains NZC/Bl, NZO/Bl, NZY/Bl and NZB/Bl. Pathology 5: 303–310

    Article  PubMed  CAS  Google Scholar 

  • Bostock DE, Owen LN (1975) Neoplasia in the cat, dog and horse. Year Book Medical Publishers, Chicago, pp 62–65

    Google Scholar 

  • Carter RL (1968) Pathology of ovarian neoplasms in rats and mice. Eur J Cancer 3: 537–543

    Article  PubMed  CAS  Google Scholar 

  • Demopoulos RI, Kammerman S (1981) Fine structural evidence on the origin of gonadotropin-induced ovarian tumors in mice. Cancer Res 41: 871–876

    PubMed  CAS  Google Scholar 

  • Fortune JE, Eppig JJ (1979) Effekt of gonadotropins on steroid secretion by infantile and juvenile mouse ovaries in vitro. Endocrinology 105:760–768

    Article  PubMed  CAS  Google Scholar 

  • Fox H (1985) Sex cord-stromal tumours of the ovary. J Pathol 145:127–148

    Article  PubMed  CAS  Google Scholar 

  • Frith CH, Zuna RE, Morgan K (1981) A morphologic classification and incidence of spontaneous ovarian neoplasms in three strains of mice. JNCI 67: 693–702

    PubMed  CAS  Google Scholar 

  • Furth J, Butterworth JS (1936) Neoplastic diseases occurring among mice subjected to general irradiation with X-rays. II. Ovarian tumors and associated lesions. Am J Cancer 28:66–95

    Google Scholar 

  • Geary CP (1984) Carcinogen-induced granulosa cell tumours in NZC/BL mice. Pathology 16:131–135

    Article  PubMed  CAS  Google Scholar 

  • Gee DC, Russell P (1981) The pathological assessment of ovarian neoplasms. IV. The sex cord-stromal tumours. Pathology 13: 235–255

    Article  PubMed  CAS  Google Scholar 

  • Gelberg HB, McEntee K (1985) Feline ovarian neoplasms. Vet Pathol 22: 572–576

    Article  PubMed  CAS  Google Scholar 

  • Gregson RL, Lewis DJ, Abbott DP (1984) Spontaneous ovarian neoplasms of the laboratory rat. Vet Pathol 21: 292–299

    PubMed  CAS  Google Scholar 

  • Hamlett JD, Aparicio SR, Lumsden CE (1971) Light- and electron-microscope studies on experimentally induced tumours of the theca-granulosa cell series in the mouse. J Pathol 105:111–124

    Article  PubMed  CAS  Google Scholar 

  • Howell JS, Marchant J, Orr JW (1954) The induction of ovarian tumours in mice with 9:10-dimethyl-1:2- benzanthracene. Br J Cancer 8: 635–646

    Article  PubMed  CAS  Google Scholar 

  • Lack EE, Perez-Atayde AR, Murthy ASK, Goldstein DP, Crigler JF, Vawter GF (1981) Granulosa theca cell tumors in premenarchal girls. A clinical and pathologic study often cases. Cancer 48:1846–1854

    Article  PubMed  CAS  Google Scholar 

  • Lemon PG, Gubareva AV (1979) Tumors of the ovary. IARC Sci Publ 23: 385–409

    PubMed  CAS  Google Scholar 

  • Marchant J (1980) Animal models for tumours of the ovary. UICC Tech Rep Ser 11: 50–65

    Google Scholar 

  • Moulton JE (ed) (1978) Tumors in domestic animals. University of California Press, Berkeley

    Google Scholar 

  • Murphy ED (1980) Major experimental models of ovarian tumors: histogenesis and evaluation. UICC Tech Rep Ser 11:66–73

    Google Scholar 

  • Murphy ED, Russell ES (1963) Ovarian tumorigenesis following genie deletion of germ cells in hybrid mice. Acta Unio Int Contra Cancrum 19:779–782

    PubMed  CAS  Google Scholar 

  • Nielsen SW, Misdorp W, McEntee K (1976) Tumors of the ovary. Bull WHO 53:203–215

    PubMed  CAS  Google Scholar 

  • Rehm S, Dierksen D, Deerberg F (1984) Spontaneous ovarian tumors in Han: NMRI mice: histologic classification, incidence, and influence of food restriction. JNCI 72:1383–1395

    PubMed  CAS  Google Scholar 

  • Scully RE (1977) Ovarian tumors. Am J Pathol 87: 686–720

    PubMed  CAS  Google Scholar 

  • Young RH, Scully RE (1982) Ovarian sex cord-stromal tumors. Recent progress. Int J Gynecol Pathol 1:101–123

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Alison, R.H., Morgan, K.T. (1987). Granulosa Cell Tumor, Ovary, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Genital System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72550-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-72550-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-72552-4

  • Online ISBN: 978-3-642-72550-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics