Abstract
Granulosa cell tumors may be up to 3 cm in diameter. Small tumors may only be detected by microscopic examination. Benign tumors are encapsulated, often nodular, solid or cystic, and gray to yellow. Malignent tumors are larger, are pink in color, and frequently contain hemorrhagic cysts. Those malignant tumors composed of multiple small nodules are often contained within the ovarian bursa.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alison RH, Morgan KT, Haseman JK, Boorman GA (1987) Morphology and classification of ovarian neoplasms in F344 rats and B6C3F1 mice. To be published
Bauminger S, Webb C, Okon E (1979) Characterization of a spontaneous granulosa cell tumor in SWR mice. Cancer Treat Rep 63:1178
Beamer WG, Hoppe PC, Whitten WK (1985) Spontaneous malignant granulosa cell tumors in ovaries of young SWR mice. Cancer Res 45: 5575–5581
Bielschowsky M, d’Ath EF (1973) Spontaneous granulosa cell tumours in mice of strains NZC/Bl, NZO/Bl, NZY/Bl and NZB/Bl. Pathology 5: 303–310
Bostock DE, Owen LN (1975) Neoplasia in the cat, dog and horse. Year Book Medical Publishers, Chicago, pp 62–65
Carter RL (1968) Pathology of ovarian neoplasms in rats and mice. Eur J Cancer 3: 537–543
Demopoulos RI, Kammerman S (1981) Fine structural evidence on the origin of gonadotropin-induced ovarian tumors in mice. Cancer Res 41: 871–876
Fortune JE, Eppig JJ (1979) Effekt of gonadotropins on steroid secretion by infantile and juvenile mouse ovaries in vitro. Endocrinology 105:760–768
Fox H (1985) Sex cord-stromal tumours of the ovary. J Pathol 145:127–148
Frith CH, Zuna RE, Morgan K (1981) A morphologic classification and incidence of spontaneous ovarian neoplasms in three strains of mice. JNCI 67: 693–702
Furth J, Butterworth JS (1936) Neoplastic diseases occurring among mice subjected to general irradiation with X-rays. II. Ovarian tumors and associated lesions. Am J Cancer 28:66–95
Geary CP (1984) Carcinogen-induced granulosa cell tumours in NZC/BL mice. Pathology 16:131–135
Gee DC, Russell P (1981) The pathological assessment of ovarian neoplasms. IV. The sex cord-stromal tumours. Pathology 13: 235–255
Gelberg HB, McEntee K (1985) Feline ovarian neoplasms. Vet Pathol 22: 572–576
Gregson RL, Lewis DJ, Abbott DP (1984) Spontaneous ovarian neoplasms of the laboratory rat. Vet Pathol 21: 292–299
Hamlett JD, Aparicio SR, Lumsden CE (1971) Light- and electron-microscope studies on experimentally induced tumours of the theca-granulosa cell series in the mouse. J Pathol 105:111–124
Howell JS, Marchant J, Orr JW (1954) The induction of ovarian tumours in mice with 9:10-dimethyl-1:2- benzanthracene. Br J Cancer 8: 635–646
Lack EE, Perez-Atayde AR, Murthy ASK, Goldstein DP, Crigler JF, Vawter GF (1981) Granulosa theca cell tumors in premenarchal girls. A clinical and pathologic study often cases. Cancer 48:1846–1854
Lemon PG, Gubareva AV (1979) Tumors of the ovary. IARC Sci Publ 23: 385–409
Marchant J (1980) Animal models for tumours of the ovary. UICC Tech Rep Ser 11: 50–65
Moulton JE (ed) (1978) Tumors in domestic animals. University of California Press, Berkeley
Murphy ED (1980) Major experimental models of ovarian tumors: histogenesis and evaluation. UICC Tech Rep Ser 11:66–73
Murphy ED, Russell ES (1963) Ovarian tumorigenesis following genie deletion of germ cells in hybrid mice. Acta Unio Int Contra Cancrum 19:779–782
Nielsen SW, Misdorp W, McEntee K (1976) Tumors of the ovary. Bull WHO 53:203–215
Rehm S, Dierksen D, Deerberg F (1984) Spontaneous ovarian tumors in Han: NMRI mice: histologic classification, incidence, and influence of food restriction. JNCI 72:1383–1395
Scully RE (1977) Ovarian tumors. Am J Pathol 87: 686–720
Young RH, Scully RE (1982) Ovarian sex cord-stromal tumors. Recent progress. Int J Gynecol Pathol 1:101–123
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Alison, R.H., Morgan, K.T. (1987). Granulosa Cell Tumor, Ovary, Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Genital System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72550-0_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-72550-0_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-72552-4
Online ISBN: 978-3-642-72550-0
eBook Packages: Springer Book Archive