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Ischemia/Reperfusion of the Gut

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1998

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1998))

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Abstract

The blood supply of the gut is compromised during different forms of shock to sustain the blood supply to the essential organs; the heart, brain and lung [1,2]. Even in hyperdynamic septic shock with normal to supranormal superior mesenteric artery blood flow, ischemic regions due to an inhomogenous perfusion of the microcirculation have been found [3]. Ischemia of the gut also occurs during various surgical procedures, where a temporary cessation of the intestinal blood supply is necessary, or where low flow states are used, as in cardiac and vascular surgery [4]. Ischemia of the gut has been implicated as potentially hazardous due to bacterial translocation and/or inflammatory reactions which can initiate or perpetuate sepsis leading to multiorgan failure [5–7]. The dimension and duration of this oxygen depletion determines the severity of the resulting cellular dysfunction or necrosis. A reduction of intestinal blood supply of greater than 50% has been found to induce relevant tis-sue damage [8,9].

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Authors
  1. M. Siegemund
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  2. W. Studer
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  3. C. Ince
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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Siegemund, M., Studer, W., Ince, C. (1998). Ischemia/Reperfusion of the Gut. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1998. Yearbook of Intensive Care and Emergency Medicine, vol 1998. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-72038-3_55

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  • DOI: https://doi.org/10.1007/978-3-642-72038-3_55

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63798-1

  • Online ISBN: 978-3-642-72038-3

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