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Use of Dexamethasone and Frusemide in Brain Edema Resulting from Brain Tumors

  • Chapter
Treatment of Cerebral Edema

Abstract

Referring to our previous papers [34, 35, 36, 40] concerning the treatment of peritumoral brain edema (BE) we have presented three possibilities for the assessment of antiedema treatment in brain tumor patients. By the use of these methods:

  1. 1.

    determination of water and electrolyte content in the peritumoral edema,

  2. 2.

    CT follow-up studies,

  3. 3.

    progress of neurological condition,

it is possible to estimate the quantitative effectiveness of different forms of antiedema treatment separately and in combination. This is important for the patient suffering from brain tumor since the antiedema treatment has to be adapted to the individual situation according to the presence or absence of symptoms of increased intracranial pressure (ICP), symptoms of impending herniation, as well as to the degree of peritumoral BE, the nature of the tumor, timing of craniotomy/biopsy (often determined by extrinsic factors) etc. In this study we have tested only two substances which are very important in antiedema therapy (apart from intensive care) namely, dexamethasone (D) and frusemide (F) as well as their combination (D/F).

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References

  1. Adachi M, Feigin I (1966) Cerebral oedema and the water content of normal white matter. J Neurol Neurosurg Psychiat 29: 446–450

    Article  PubMed  CAS  Google Scholar 

  2. Baethmann A, Lanksch W, Schmiedek P (1974) Formation and treatment of cerebral edema. Neurochirurgia 17, 37–47

    PubMed  CAS  Google Scholar 

  3. Baethmann A, Oettinger W, Rothenfusser R (1977) Chemical mediator compounds in brain edema. Eur Surg Res 9:( Suppl. I), 121–122

    Google Scholar 

  4. Brock M, Wiegand H, Zillig C, Zywietz C, Mock P, Dietz H (1976) The effect of dexamethasone on intracranial pressure in patients with supra tentorial tumors. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 330–336

    Google Scholar 

  5. Clasen RA, Huchman MS, Pandolfi S, Laing I, Jacobs J (1976) Computed tomography of vasogenic cerebral edema. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 278–282

    Google Scholar 

  6. Clasen RA, Huckmann MS, von Roenn KA, Pandolfi S, Laing I, Clasen JR (1980) Time course of cerebral swelling in stroke: A correlative autopsy and CT study. Advances in Neurology 28: 395–412

    PubMed  CAS  Google Scholar 

  7. Cserr HF, Cooper DN, Milhorat TH (1976) Production, circulation and absorption of brain interstitial fluid. In: Dynamics of brain edema. Pappius HM, Feindel W (eds )

    Google Scholar 

  8. Faupel G, Reulen HJ, Müller D, Schürmann K (1976) Double-blind study on the effects of steroids on severe closed head injury. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 337 - 343

    Google Scholar 

  9. Faupel G, Reulen HJ, Müller D, Schürmann K (1978) Dexamethason bei schweren Schädel-Hirn-Traumen. Akt traumatol 8: 265 – 281

    Google Scholar 

  10. Fenske A, Fischer M, Regli F, Hase U (1979) The response of focal ischemic cerebral edema to Dexamethasone. J Neurol 220: 199–209

    Article  PubMed  CAS  Google Scholar 

  11. Frei HJ, Poll W, Reulen HJ, Brock M, Schürmann K (1971) Regional energy metabolism, tissue lactate content and rCBF in cold injury edema. In: Brain and blood flow. Ross Rüssel RW (ed). Pitman Medical and Scientific Publishing Co, London, pp 125–129

    Google Scholar 

  12. Frei HJ, Wallenfang Th, Poll W, Schubert R, Brock M (1973) Regional cerebral blood flow and regional metabolism in cold induced brain edema. Acta Neurochirurg 29: 15–28

    Article  CAS  Google Scholar 

  13. Gaab M, Knoblich OE, Schupp J, Dietrich K, Fuhrmeister U, Gruss P (1978) Wirkung unterschiedlicher Osmo- und Onkotherapie auf Hirndruck und elektrische Hirnaktivität beim experimentellen Hirnödem. Acta Neurochir 40: 203–221

    Article  CAS  Google Scholar 

  14. Galicich JH, French LA (1961) Use of dexamethasone in the treatment of cerebral edema resulting from brain tumors and brain surgery. Am Practitioner 12: 169–174

    PubMed  CAS  Google Scholar 

  15. Geigy wissenschaftliche Tabellen. 7. Auflage, p 515, 1968

    Google Scholar 

  16. Hadjidimos A, Brock M, Haas JP, Dietz H, Wolf R, Ellger M, Fischer F, Schürmann K (1969) Correlation between rCBF, angiography, EEG and Scanning in brain tumors. In: Cerebral blood flow. Springer, Berlin Heidelberg New York, pp 190–193

    Google Scholar 

  17. Hadjidimos A, Steingass U, Fischer F, Reulen HJ, Schürmann K (1973) The effect of dexamethasone on rCBF and cerebral vasomotor response in brain tumor. Eur Neurol 10: 25–30

    Article  PubMed  CAS  Google Scholar 

  18. Hartmann A, Schütz HJ, Alberti E, Schreckenberger F, Loew F, Pycka J (1977) Effects of a new diuretic on Cerebrospinal Fluid Pressure in patients with supratentorial tumors. Arch Psychiat Nervenkr 224: 351–360

    Article  PubMed  CAS  Google Scholar 

  19. Hartmann A, Alberti E (1977) Eine einfache Methode zur kontinuierlichen Messung des Liquordrucks. Acta Neurochir 36: 201–214

    Article  CAS  Google Scholar 

  20. Hartmann A, Alberti E (1977) Differentiation of communicating hydrocephalus and presenile dementia by continuous recording of cerebrospinal fluid pressure. J Neurol Neurosurg Psychiat 40: 630–640

    Article  PubMed  CAS  Google Scholar 

  21. Hase U (1978) Intrakranielle Drucksteigerung. Neurochirurgia 21: 145–157

    PubMed  CAS  Google Scholar 

  22. Hase U, Reulen HJ, Meinig G, Schürmann K The influence of the decompressive operation on the intracranial pressure and the pressure-volume relation in patients with severe head injuries. Acta Neurochir (in press)

    Google Scholar 

  23. Klatzo I, Wisniewski H, Steinwall O, Streicher E (1967) Dynamics of cold injury edema. In: Brain edema. Klatzo I, Seitelberger F (eds). Springer, Wien New York, pp 554–563

    Google Scholar 

  24. Lanksch W, Oettinger W, Baethmann A, Kazner E (1976) CT findings in brain edema compared with direct chemical analysis of tissue samples. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 283–287

    Google Scholar 

  25. Lanksch W, Kazner E (1976) CT findings in brain edema. In: Cranial Computerized Tomography. Lanksch W, Kazner E (eds). Springer, Berlin Heidelberg New York, pp 344–355

    Google Scholar 

  26. Long DM, Hartmann JF, French LA (1966) The response of human cerebral edema to glucosteroid administration. Neurology 16: 521–528

    PubMed  CAS  Google Scholar 

  27. Long DM, Maxwell RE, French LA (1971) The effects of glucosteroids upon cold induced brain edema. J Neuropathol Exp Neurol 30: 680–697

    Article  PubMed  CAS  Google Scholar 

  28. Long DM, Maxwell RE, Choi KS, Cole HO, French LA (1972) Multiple therapeutic ap-proaches in the treatment of brain edema induced by a standard cold lesion. In: Steroids and brain edema. Reulen HJ, Schürmann K (eds). Springer, Berlin Heidelberg New York, pp 87–94

    Google Scholar 

  29. Long DM, Maxwell RE, Choi KS (1976) A new therapy regimen for brain edema. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 293–300

    Google Scholar 

  30. Marshall LF, Bruce DA, Graham DI (1976) Alterations in behavior, brain electrical activity, cerebral blood flow, and intracranial pressure produced by triethyl tin sulfate induced cerebral edema. Stroke 7: 21–25

    Article  PubMed  CAS  Google Scholar 

  31. Marshall LF (1980) Treatment of brain swelling and brain edema in man. Advances in Neurology 28: 459–469

    PubMed  CAS  Google Scholar 

  32. Maxwell RE, Long DM, French LA (1971) The effects of glucosteroids upon cold-induced brain edema. In: Gross morphological vascular permeability changes. J Neurosurg 34: 477–487

    Google Scholar 

  33. Maxwell RE, Long DM, French LA (1972) The clinical effects of a synthetic glucocorticoid used for brain edema in the practice of neurosurgery. In: Steroids and brain edema. Reulen HJ, Schürmann K (eds). Springer, Berlin Heidelberg New York, pp 219–232

    Google Scholar 

  34. Meinig G, Aulich A, Wende S, Reulen HJ (1976) Resolution of peritumoral brain edema following combination therapy with dexamethasone and furosemide. Adv Neurosurg 4: 207–211

    Google Scholar 

  35. Meinig G, Aulich A, Wende S, Reulen HJ (1976) The effect of dexamethasone and diuretics on peri tumor brain edema: Comparative study of tissue water content and CT. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 301–305

    Google Scholar 

  36. Meinig G, Reulen HJ, Simon RS, Schürmann K (1980) Clinical, chemical and CT evaluation of short-term and long-term antiedema therapy with dexamethasone and diuretics. Advances in Neurology 28: 471–489

    PubMed  CAS  Google Scholar 

  37. Miller JD, Gudeman SK, Kishore PS, Becker DP (1980) Computed tomography in brain edema due to trauma. Advances in Neurology 28: 413–422

    PubMed  CAS  Google Scholar 

  38. Pappius HM (1972) Effects of steroids on cold injury edema. In: Steroids and brain edema. Reulen HJ, Schürmann K (eds). Springer, Berlin Heidelberg New York, pp 57–63

    Google Scholar 

  39. Penn RD (1980) Cerebral edema and neurological function: CT, evoked responses, and clinical examination. Advances in Neurology 28: 383–394

    PubMed  CAS  Google Scholar 

  40. Reulen HJ, Hadjidimos A, Schürmann K (1972) The effect of dexamethasone on water and electrolyte content and on rCBF in perifocal brain edema in man. In: Steroids and brain edema. Reulen HJ, Schürmann K (eds). Springer, Berlin Heidelberg New York, pp 239–252

    Google Scholar 

  41. Reulen HJ, Graham R, Fenske A, Tsuyumu M, Klatzo I (1976) The role of tissue pressure and bulk flow in the formation and resolution of cold-induced edema. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 103–112

    Google Scholar 

  42. Reulen HJ, Graham R, Spatz M, Klatzo I (1977) Role of pressure gradients and bulk flow in dynamics of vasogenic brain edema. J Neurosurg 46: 24–35

    Article  PubMed  CAS  Google Scholar 

  43. Schmiedek P, Guggemos L, Baethmann A, Lanksch W, Kazner E, Picha B, Oltenau-Nerbe V, Enzenbach R, Brendel W, Marguth F (1976) Re-evaluation of short-term steroid therapy for perifocal brain edema. In: Dynamics of brain edema. Pappius HM, Feindel W (eds). Springer, Berlin Heidelberg New York, pp 344–350

    Google Scholar 

  44. Thilmann J, Zeumer H (1974) Untersuchungen zur Behandlung des Hirnödems mit hohen Dosen Furosemid. Dtsch Med Wschr 99: 932–935

    Article  Google Scholar 

  45. Yates AJ, Thelmo W, Pappius HM (1975) Post-mortem changes in the chemistry and histology of normal and edematous brains. Am J Pathol 79: 555–564

    PubMed  CAS  Google Scholar 

  46. Begleitblatt und Verlaufskontrolle fur Schädel-Hirnverletzte (6. Aufl.) (Faupel et al.)

    Google Scholar 

  47. Verlaufskontrollblatt fur die Neurochirurgische Intensivstation, deployed by Arbeitsgruppe “Schädel-Hirntrauma” der Deutschen Gesellschaft fur Neurochirurgie

    Google Scholar 

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Authors
  1. G. Meinig
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  2. H. J. Reulen
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  3. S. Wende
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  4. K. Schürmann
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Editors and Affiliations

  1. Neurologische Klinik, Klinikum der Universität Heidelberg, Ruprecht-Karls-Universität Heidelberg, Vosstraße 2, D-6900, Heidelberg 1, Germany

    Alexander Hartmann

  2. Abteilung für Neurochirurgie, Neurochirurgische/Neurologische Klinik und Poliklinik, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, D-1000, Berlin 45, Germany

    Mario Brock

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Meinig, G., Reulen, H.J., Wende, S., Schürmann, K. (1982). Use of Dexamethasone and Frusemide in Brain Edema Resulting from Brain Tumors. In: Hartmann, A., Brock, M. (eds) Treatment of Cerebral Edema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68707-5_14

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  • DOI: https://doi.org/10.1007/978-3-642-68707-5_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11751-3

  • Online ISBN: 978-3-642-68707-5

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