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Intracoronary Thrombolysis in Evolving Myocardial Infarction

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Nitrates III

Abstract

Extensive myocardial injury remains the major cause of death and morbidity among patients admitted to a hospital with acute myocardial infarction. Massive injury produces heart failure, cardiogenic shock, and lethal ventricular arrhythmias [6]. Ways have therefore been sought to limit the extent and severity of ischemic injury by increasing collateral blood supply and/or reducing myocardial oxygen demand. Most of the studied interventions were effective in the experimental animal, but in the clinical setting they have thus far been less than satisfactory. For this reason, the possibility of maximum revascularization by restoration of antegrade flow in the occluded coronary artery has recently attracted increased attention as a method of radically changing the prognosis of patients with evolving myocardial infarction.

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References

  1. Boucek RJ, Murphy WP jr (1960) Segmental perfusion of the coronary arteries with fibrinolysin in man following a myocardial infarction. Am J Cardiol 6: 525–530

    Article  PubMed  CAS  Google Scholar 

  2. Branwood AW, Montgomery GL (1956) Observations on the morbid anatomy of coronary diseases. Scott med J 1: 367–375

    PubMed  CAS  Google Scholar 

  3. Chandler AB, Chapman I, Erhardt LR, Roberts WC, Schwartz CJ, Sinapius D, Spain DM, Sherry S, Ness PM, Simon TL (1974) Coronary thrombosis in myocardial infarction. Am J Cardiol 34: 823–830

    Article  PubMed  CAS  Google Scholar 

  4. Chierchia S, Marchesi C, Maseri A (1978) Evidence of angina not caused by increased myocardial metabolic demand and patterns of electrocardiographic and hemodynamic alterations during “primary” angina. In: Maseri A, Klassen GA, Lesch M (eds) Primary and secondary angina pectoris. Grune and Stratton, New York, pp 145–155

    Google Scholar 

  5. Figueras J, Singh B, Ganz W, Charuzi Y, Swan HJC (1979) Mechanism of rest and nocturnal angina: Observations during continuous hemodynamic and electrocardiographic monitoring. Circulation 59: 955–968

    PubMed  CAS  Google Scholar 

  6. Friedman M, van den Bovenkamp GTP (1966) Pathogenesis of a coronary thrombus. Am J Pathol 48: 19–25

    PubMed  CAS  Google Scholar 

  7. Harnarayan C, Bennett MA, Pentecost BL, Brewer DB (1970) Quantitative study of infarcted myocardium in cardiogenic shock. Br Heart J 32: 728–732

    Article  PubMed  CAS  Google Scholar 

  8. Jennings RB, Baum HG, Herdson PB (1965) Fine structural changes in myocardial ischemic injury. Arch Pathol 79: 135–143

    PubMed  CAS  Google Scholar 

  9. Kanmatsuse K, Lando U, Mercier J, Fishbein M, Swan HJC, Ganz W (1979) Rapid lysis of coronary thrombi by local application of fibrinolysin. Circulation [Suppl II] 60: 216

    Google Scholar 

  10. Maseri A, L’Abbate A, Baroldi G, Chierchia S, Marzilli M, Ballestra AM, Severi S, Parodi O, Biagini A, Distante A, Pesóla A (1978) Coronary vasospasm as a possible cause of myocardial infarction: a conclusion derived from the study of “preinfarction” angina. New Engl J Med 299: 1271–1277

    Article  PubMed  CAS  Google Scholar 

  11. Miura M, Thomas R, Ganz W, Sokol T, Shell WE, Toshimitsu T, Kwan AC, Singh B (1979) The effect of delay in propranolol administration on reduction of myocardial infarct size after experimental coronary artery occlusion in dogs. Circulation 59: 1148–1157

    PubMed  CAS  Google Scholar 

  12. Oliva PB, Breckinridge JC (1977) Arteriographic evidence of coronary arterial spasm in acute myocardial infarction. Circulation 56: 366–375

    PubMed  CAS  Google Scholar 

  13. Rentrop KP, Blanke H, Karsch KR, Wiegand V, Koestering H, Oster H, Leitz K (1979) Acute myocardial infarction: Intracoronary application of nitroglycerin and streptokinase in combination with transluminal recanalization. Clin Cardiol 2: 354–360

    PubMed  CAS  Google Scholar 

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Authors
  1. W. Ganz
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  2. N. Buchbinder
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  3. H. Marcus
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  4. A. Mondkar
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  5. L. O’Connor
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  6. J. Maddahi
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  7. D. Berman
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  8. Y. Charuzi
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  9. C. Beeder
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  10. T. Peter
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  11. P. K. Shah
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  12. W. Shell
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  13. H. J. C. Swan
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Editor information

Editors and Affiliations

  1. Abteilung fĂĽr Kardiologie, Med. Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Germany

    P. R. Lichtlen

  2. Zentralkrankenhaus „Links der Weser“, Senator-Weßling-Straße, D-2800, Bremen 61, Germany

    H.-J. Engel

  3. Pharma-Schwarz GmbH, D-4019, Monheim, Germany

    A. Schrey

  4. Dept. of Cardiology, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, 90048, Los Angeles, Calif., USA

    H. J. C. Swan (Director) (Director)

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© 1981 Springer-Verlag Berlin Heidelberg

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Ganz, W. et al. (1981). Intracoronary Thrombolysis in Evolving Myocardial Infarction. In: Lichtlen, P.R., Engel, HJ., Schrey, A., Swan, H.J.C. (eds) Nitrates III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68085-4_55

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  • DOI: https://doi.org/10.1007/978-3-642-68085-4_55

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68087-8

  • Online ISBN: 978-3-642-68085-4

  • eBook Packages: Springer Book Archive

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