Abstract
The lymphocyte is perhaps a unique cell in human biology because of the remarkable alterations in appearance and metabolic activity that result when activation occurs following antigenic stimulation (7). The activated lymphocyte has many of the metabolic and morphologic features generally observed in malignant cells. Because of these rapid and dramatic changes in appearance and activity as the cell changes from benign to belligerent, it is not surprising that a number of traps exist for individuals studying lymphoid diseases, and especially malignancies, with the microscope. Willis summarized the problem when he stated that “nowhere in pathology has a chaos of names so clouded clear concepts as in the subject of lymphoid tumors” (16). A new approach to the analysis of lymphoid malignancies was suggested by observations indicating the subsets of normal lymphocytes bear specific membrane-surface markers (7). In the past several years a significant body of evidence has been collected indicating that the surface phenotypes of normal lymphocytes are frequently retained in malignancies of lymphoid cells (9). The surface characteristics of human lymphoid malignancies as studied in our institution are the subject of this report.
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Kersey, J. et al. (1977). Surface Markers Define Human Lymphoid Malignancies with Differing Prognoses. In: Thierfelder, S., Rodt, H., Thiel, E. (eds) Immunological Diagnosis of Leukemias and Lymphomas. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66639-1_2
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DOI: https://doi.org/10.1007/978-3-642-66639-1_2
Publisher Name: Springer, Berlin, Heidelberg
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