Abstract
The effects of total ischemia on the energy state of the brain are well documented. These changes consist in a rapid disappearance of available substrates (glucose and glycogen) and of high energy compounds (phosphocreatine and ATP), and in an accumulation of AMP, inorganic P (Pi), and lactate. The magnitude of the increase in the lactate concentration is determined by the pre-ischemic levels of glucose and glycogen which usually suffice to increase the tissue lactate content from about 1.5 to about 15 mMoles/kg of wet tissue. The increase in lactate is maximal within a few minutes of ischemia. Therefore, 3–5 min of total ischemia leads to a state of severe and maximal tissue acidosis and of complete energy depletion [1, 2, 3, 4, 5, 6].
Supported by grants from the Swedish Medical Research Council (Project No. B 72-14 X-2179-04 and B72-14X-263-08B), from the Swedish Bank Tercentenary Fund, and by U.S. PHS Grant No. 5 R01 NS 07838-03 from NIH.
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Ljunggren, B., Granholm, L., Schutz, H., Siesjö, B.K. (1972). Energy State of the Brain during and after Compression Ischemia. In: Brock, M., Dietz, H. (eds) Intracranial Pressure. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65486-2_16
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DOI: https://doi.org/10.1007/978-3-642-65486-2_16
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