Skip to main content

The Spleen in Hematologic Disorders

  • Chapter
Medical Imaging of the Spleen

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Embryologically, the spleen develops from mesenchymal cells between the two mesothelial layers of the mesogastrium. These cells form the splenic pulp, the supporting connective tissue structures, and the capsule of the spleen. The primitive artery penetrates a lobulated embryonic spleen, and arterioles branch through the connective tissue into the splenic sinusoids. Continued growth and formation occurs during fusion of the splenic lobules.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adler DD, Glazer GM, Aisen AM (1986) MRI of the spleen: normal appearance and findings in sickle-cell anemia. AJR Am J Roentgenol 147:843–845

    PubMed  CAS  Google Scholar 

  • Ambriz P, Munoz R, Quintanar E, et al. (1985) Accessory spleen compromising response to splenectomy for idiopathic thrombocytopenic purpura. Radiology 155:793–796

    PubMed  CAS  Google Scholar 

  • Anonymous (1997) Imaging interpretation session: 1996. Paroxysmal nocturnal hemoglobinuria (PNH). Radiographics 17:263–265

    Google Scholar 

  • Balcar I, Seltzer SE, Davis S, et al. (1984) CT patterns of splenic infarction: a clinical and experimental study. Radiology 151:723–729

    PubMed  CAS  Google Scholar 

  • Castleman B, Iverson L, Mecendez VP (1956) Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 9:822–830

    Article  PubMed  CAS  Google Scholar 

  • Cirillo RL, Vitellas KM, Deyoung BR, et al. (1998) Castleman disease: mimicking a hepatic neoplasm. Clin Imaging 22:124–129

    Article  PubMed  Google Scholar 

  • Coon WW (1987) Splenectomy for idiopathic thrombocytopenic purpura. Surg Gynecol Obstet 164:225–229

    PubMed  CAS  Google Scholar 

  • Corredoira JC, Gonzales M, Perez R, et al. (1990) A clinical and biological study of 33 cases of polycythemia vera. Rev Clin Esp 186:378–382

    PubMed  CAS  Google Scholar 

  • Doan CA, Bouroncle BA, Wiseman BK (1960) Idiopathic and secondary thrombocytopenic purpura: clinical study and evaluation of 381 cases over a period of 28 years. Ann Intern Med 53:861–876

    Google Scholar 

  • Downer WR, Peterson MS (1993) Massive splenic infarction and liquefactive necrosis complicating polycythemia vera. AJR Am J Roentgenol 161:79–80

    PubMed  CAS  Google Scholar 

  • Ernst O, Sergent G, Bonvarlet P, et al. (1997) Hepatic iron overload: diagnosis and quantification with MR imaging. AJR Am J Roentgenol 168:1205–1208

    PubMed  CAS  Google Scholar 

  • Fischer KC, Shapiro S, Treves S (1977) Visualization of the spleen with a bone-seeking radionuclide in a child with sickle-cell anemia. Radiology 122:398

    PubMed  CAS  Google Scholar 

  • Fishbone G, Nunez D, Leon R, et al. (1977) Massive splenic infarction in sickle cell-hemoglobin C disease: angiographic findings. AJR Am J Roentgenol 129:927–928

    PubMed  CAS  Google Scholar 

  • Gandon Y, Guyader D, Heautot JF, et al. (1994) Hemochromatosis: diagnosis and quantification of liver iron with gradient-echo MR imaging. Radiology 193:533–538

    PubMed  CAS  Google Scholar 

  • Hunter TB, Haber K (1977) Unusual sonographic appearance of the spleen in a case of myelofibrosis. AJR Am J Roentgenol 128:138–139

    PubMed  CAS  Google Scholar 

  • Jacobs A (1977) Iron overload-clinical and pathologic aspects. Semin Hematol 14:89–113

    PubMed  CAS  Google Scholar 

  • Libson E, Fields S, Strauss S, et al. (1988) Widespread Castleman disease: CT and US findings. Radiology 166:753–755

    PubMed  CAS  Google Scholar 

  • Long JA Jr, Doppman JL, Nienhus AW, et al. (1980) Computed tomographic analysis of b-thalassemic syndromes with hemochromatosis: pathologic findings with clinical and laboratory correlations. J Comput Assist Tomogr 4:159–165

    Article  PubMed  Google Scholar 

  • Magid D, Fishman EK, Siegelman SS (1984) Computed tomography of the spleen and liver in sickle cell disease. AJR Am J Roentgenol 143:245–249

    PubMed  CAS  Google Scholar 

  • McCall IW, Vaidya S, Serjeant GR (1981) Splenic opacification in homozygous sickle cell disease. Clin Radiol 32:611–615

    Article  PubMed  CAS  Google Scholar 

  • Mitnick JS, Bosniak MA, Megibow A, et al. (1981) CT in b-thalassemia: iron deposition in the liver, spleen, and lymph nodes. AJR Am J Roentgenol 136:1191–1194

    PubMed  CAS  Google Scholar 

  • Mueller-Eckhardt C (1977) Idiopathic thrombocytopenic purpura (ITP):clinical and immunologic considerations. Semin Thromb Hemost 3:125–159

    PubMed  CAS  Google Scholar 

  • Perlmutter S, Jacobstein JG, Kazam E (1977) Splenic uptake of Tc-99m-diphosphonate in sickle cell disease associated with increased splenic density on computerized transaxial tomography. Gastrointest Radiol 2:77–79

    Article  PubMed  CAS  Google Scholar 

  • Ridson RA, Barry M, Flynn DM (1975) Transfusional iron overload: the relationship between tissue iron concentration and hepatic fibrosis in thalassemia. J Pathol 116:83–95

    Article  Google Scholar 

  • Roshkow JE, Sanders LM (1990) Acute splenic sequestration crisis in two adults with sickle cell disease: US, CT and MR imaging findings. Radiology 177:723–725

    PubMed  CAS  Google Scholar 

  • Shirkhoda A (1987) CT findings in hepatosplenic and renal candidiasis. J Comput Assist Tomogr 11:795–798

    Article  PubMed  CAS  Google Scholar 

  • Siegelman ES, Outwater E, Hanau CA, et al. (1994) Abdominal iron distribution in sickle cell disease: MR findings in transfusion and non-transfusion dependent patients. J Comput Assist Tomogr 18:63–67

    Article  PubMed  CAS  Google Scholar 

  • Siler J, Hunter TB, Weiss J, et al. (1980) Increased echogenicity of the spleen in benign and malignant disease. AJR Am J Roentgenol 134:1011–1014

    PubMed  CAS  Google Scholar 

  • Srikanth M, Mohan VS, Reddy JJM (1994) Calcinc splenomegaly in polycythemia vera. AJR Am J Roentgenol 163:747

    PubMed  CAS  Google Scholar 

  • Witzleben CL, Wyatt JP (1961) The effect of long survival on the pathology of thalassemia major. J Pathol 82:1–12

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Ito, K., Mitchell, D.G. (2000). The Spleen in Hematologic Disorders. In: De Schepper, A.M., Vanhoenacker, F. (eds) Medical Imaging of the Spleen. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57045-2_5

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-57045-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62997-6

  • Online ISBN: 978-3-642-57045-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics