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Sleep Disorders in Chronic Kidney Disease

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Management of Chronic Kidney Disease

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Abstract

Epidemiological studies in CKD patients have disclosed high prevalence of sleep disorders (insomnia, restless leg syndrome, periodic limb movement disorder, central sleep apnea, obstructive sleep apnea, excessive daytime sleepiness, and a low quality sleep) which is inversely associated with eGFR. Diagnosis is made through either questionnaires, sleep logs, or polysomnography (the gold standard). Actigraphy is becoming popular because of its simplicity. Hypnotics are indicated for insomnia. Sleep apnea is best cured with nasal continuous positive airway pressure. Dopaminergic therapy has a role for restless leg syndrome (RLS) and periodic limb movements in sleep PLMS. Sleep disorders should be considered as a warning, and wake and sleep functions should be viewed as a vital sign. Any sleep complaint should be taken seriously and defined appropriately. Impaired quality of sleep is associated with impaired quality of life. Nephrologists and sleep specialists should work in close collaboration.

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References

  1. The sleep disorders. A publication of the National Sleep Foundation. Accessed on line 29 April 2014 at http://sleepdisorders.sleepfoundation.org/chapter-2-insomnia/definitions/what-is-insomnia/.

  2. Kline C. Sleep quality. In: Gellman MD, Turner JR, editors. Encyclopedia of behavioral medicine. New York: Springer; 2013. p. 1811–3 (accessed on line, July 12, 2013).

    Chapter  Google Scholar 

  3. Stanford Center for Sleep Sciences and Medicine [internet]. Redwood City: Stanford Hospitals and Clinics; 2013. Cognitive and Behavioral therapy for Insomnia. Available from: http://stanfordhospital.org/clinicsmedServices/clinics/sleep/treatment_options/cbt.html. Cited 12 Aug 2013.

  4. De Santo RM, Bartiromo M, Cesare CM, Cirillo M. Sleep disorders occur very early in chronic kidney disease. J Nephrol. 2008;21 Suppl 13:S59–65.

    PubMed  Google Scholar 

  5. Sabbatini M, Pisani A, Crispo A, Ragosta A, Gallo R, Pota A, Serio V, Tripepi G, Cianciaruso B. Sleep quality in patients with chronic renal failure: a 3-year longitudinal study. Sleep Med. 2008;9:240–6.

    Article  PubMed  Google Scholar 

  6. De Santo RM, Bilancio G, Santoro D, Li Vecchi M, Perna A, De Santo NG, Cirillo M. A longitudinal study of sleep disorders in early-stage chronic kidney disease. J Ren Nutr. 2010;20:S59–63.

    Article  PubMed  Google Scholar 

  7. Cohen SD, Patel SS, Khetpal P, Peterson RA, Kimmel PL. Pain, sleep disturbance and quality of life in patients with chronic kidney disease. Clin J Am Soc Nephrol. 2007;2:919–25.

    Article  PubMed  Google Scholar 

  8. Merlino G, Lorenzut S, Gigli GL, Romano G, Montanaro D, Moro A, Valente M. A case–control study on restless legs syndrome in nondialyzed patients with chronic renal failure. Mov Disord. 2010;25:1019–25.

    Article  PubMed  Google Scholar 

  9. Roumelioti ME, Buysse DJ, Sanders MH, Strollo P, Newman AB, Unruh ML. Sleep disordered – breathing and excessive daytime sleepiness in chronic kidney disease and hemodialysis. Clin J Am Soc Nephrol. 2011;6:986–94.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Kumar B, Tilea A, Gillespie BW, Zhang X, Kiser M, Eisele G, Finkelstein F, Kotanko P, Levin N, Rajagopalan S, Saran R. Significance of self-reported sleep quality (SQ) in chronic kidney disease (CKD): the Renal Research Institute (RRI)-CKD study. Clin Nephrol. 2010;73:104–14.

    Article  CAS  PubMed  Google Scholar 

  11. Sim JJ, Rasgon SA, Kujubu DA, Kumar VA, Liu IL, Shi JM, Pham TT, Derose SF. Sleep apnea in early and advanced chronic kidney disease: Kaiser Permanente Southern California cohort. Chest. 2009;135:710–6.

    Article  PubMed  Google Scholar 

  12. Sakaguchi Y, Shoji Y, Kawabata H, Niihata K, Suzuki A, Kaneko T, Okada N, Isaka Y, Rakugi H, Tsubakihara Y. High prevalence of obstructive sleep apnea and its association with renal function among nondialysis chronic kidney disease patients in Japan: a cross-sectional study. Clin J Am Soc Nephrol. 2011;6:995–1000.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Murtagh FE, Addington-Hall JM, Edmonds PM, Donohoe P, Carey I, Jenkins K, Higginson IJ. Symptoms in advanced renal disease: a cross-sectional survey of symptom prevalence in stage 5 chronic kidney disease managed without dialysis. J Palliat Med. 2007;10:1266–76.

    Article  PubMed  Google Scholar 

  14. Iseki K, Tohyama K, Matsumoto T, Nakamura H. High prevalence of chronic kidney disease among patients with sleep related breathing disorder (SRBD). Hypertens Res. 2008;31:249–55.

    Article  CAS  PubMed  Google Scholar 

  15. Fleischmann G, Fillafer G, Matterer H, Skrabal F, Kotanko P. Prevalence of chronic kidney disease in patients with suspected sleep apnoea. Nephrol Dial Transplant. 2010;25:181–6.

    Article  PubMed  Google Scholar 

  16. Chou YT, Lee PH, Yang CT, Lin CL, Veasey S, Chuang LP, Lin SW, Lin YS, Chen NH. Obstructive sleep apnea: a stand-alone risk factor for chronic kidney disease. Nephrol Dial Transplant. 2011;26:2244–50.

    Article  PubMed  Google Scholar 

  17. Plantinga L, Lee K, Inker LA, Saran R, Yee J, Gillespie B, Rolka D, Saydah S, Powe NR, CDC CKD Surveillance Team. Association of sleep-related problems with CKD in the United States, 2005–2008. Am J Kidney Dis. 2011;58(4):554–64.

    Article  PubMed  Google Scholar 

  18. Sim JJ, Rasgon SA, Derose SF. Review article: managing of sleep apnoea in kidney diseases. Nephrology (Carlton). 2010;15:146–52.

    Article  Google Scholar 

  19. Turek NF, Ricardo AC, Lash JP. Sleep disturbances as nontraditional risk factors for development and progression of CKD: review of the evidence. Am J Kidney Dis. 2012;60:823–33.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Koch BC, van der Putten K, Van Someren EJ, Wielders JP, Ter Wee PM, Nagtegaal JE, Gaillard CA. Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study). Nephrol Dial Transplant. 2010;25:513–9.

    Article  CAS  PubMed  Google Scholar 

  21. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russel R, Woo M, Young T. Sleep apnea and cardiovascular disease. J Am Coll Cardiol. 2008;52:686–717.

    Article  PubMed  Google Scholar 

  22. Adeseun GA, Rosas SE. The impact of obstructive sleep apnea on chronic kidney disease. Curr Hypertens Rep. 2010;12:378–83.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Kuhlmann U, Bormann FG, Becker HF. Obstructive sleep apnoea: clinical signs, diagnosis and treatment. Nephrol Dial Transplant. 2009;24:8–14.

    Article  PubMed  Google Scholar 

  24. Mallamaci F, Tripepi G. Comment accompanying: obstructive sleep apnea: a stand-alone risk factor for chronic kidney disease by Chou Yu-Ting. Nephrol Dial Transplant. 2011;26:2072–4.

    Article  PubMed  Google Scholar 

  25. Walters AS, Rye DB. Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease and stroke. Sleep. 2009;32:589–97.

    PubMed Central  PubMed  Google Scholar 

  26. Iliescu EA, Yeates KE, Holland DC. Quality of sleep in patients with chronic kidney disease. Nephrol Dial Transplant. 2004;19:95–9.

    Article  PubMed  Google Scholar 

  27. Klassen A, Di Iorio BR, Guastaferro P, Bahner U, Heidland A, De Santo NG. High-tone externalmuscle stimulation in end-stage renal disease: effects on symptomatic diabetic and uremic peripheralneuropathy. J Ren Nutr. 2008;18:46–51.

    Google Scholar 

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Authors and Affiliations

  1. Italian Institute for Philosophical Studies, 20 Salita Scudillo, Parco La Collinetta, Naples, 80131, Italy

    Rosa Maria De Santo

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  1. Rosa Maria De Santo
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Correspondence to Rosa Maria De Santo .

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Editors and Affiliations

  1. Department of Nephrology, Hacettepe University Faculty of Medicine, Ankara, Turkey

    Mustafa Arici

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De Santo, R.M. (2014). Sleep Disorders in Chronic Kidney Disease. In: Arici, M. (eds) Management of Chronic Kidney Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54637-2_25

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  • DOI: https://doi.org/10.1007/978-3-642-54637-2_25

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54636-5

  • Online ISBN: 978-3-642-54637-2

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