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Scutellaria Species

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Adverse Effects of Herbal Drugs 2

Part of the book series: Adverse Effects of Herbal Drugs ((HERBAL DRUGS,volume 2))

Abstract

Species of Scutellaria (skullcap), which belong to the family Labiatae, have been employed as herbal remedies in various parts of the world.

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References

  1. Tyler VE (1987) The New Honest Herbal. A sensible guide to herbs and related remedies. 2nd edn. Philadelphia: George F. Stickley Company, pp 216–217

    Google Scholar 

  2. Phillipson JD, Anderson LA (1984) Herbal remedies used in sedative and antirheumatic preparations: Part 1. Pharm J 233:80–82

    CAS  Google Scholar 

  3. Wenqing L (1987) Huangqin. In: Chang H-M, But PP-H, ed. Pharmacology and Applications of Chinese Materia Medica. Vol II. World Scientific Publishing Co, Singapore, pp 1022–1028

    Google Scholar 

  4. National Institute for the Control of Pharmaceutical and Biological Products (1987) Colour atlas of Chinese traditional drugs. Vol 1. Beijing: Science Press, pp 239–240

    Google Scholar 

  5. Takido M, Aimi M, Takahashi S, Yamanouchi S, Torii H, Dohi S (1975) Constituents of aqueous extracts of crude drugs. I. Root of Scutellaria baicalensis Georgi (Wogon) (I). Yakugaku Zasshi 95:108–113

    PubMed  CAS  Google Scholar 

  6. Takino Y, Miyahara T, Arichi E, Arichi S, Hayashi T, Karikura M (1987) Determination of some flavonoids in Scutellariae Radix by high-performance liquid chromatography. Chem Pharm Bull (Tokyo) 35:3494–3497

    CAS  Google Scholar 

  7. Franzblau SG, Cross C (1986) Comparative in vitro antimicrobial activity of Chinese medicinal herbs. J Ethnopharmacol 15:279–288

    Article  PubMed  CAS  Google Scholar 

  8. Vogel VJ (1970) American Indian medicine. Norman: University of Oklahoma Press, pp 366–367

    Google Scholar 

  9. Hoppe HA (1975) Drogenkunde. Band 1. Angiospermen. 8. Auflage. Berlin: Walter de Gruyter, pp 984–985

    Google Scholar 

  10. Penso G (1983) Index Plantarum Medicinalium Totius Mundi Eorumque Synonymorum. Milano: Organizzazione Editoriale Medico Farmaceutica, pp 866–867

    Google Scholar 

  11. Takido M, Yasukawa K, Matsuura S, Linuma M (1979) On the revised structure of skullcapflavone I, a flavone compound in the roots of Scutellaria baicalensis Georgi (Wogon). J Pharm Soc Japan 99:443–444

    CAS  Google Scholar 

  12. Takagi S, Yamaki M, Inoue K (1980) Studies on the water-soluble constituents of the roots of Scutellaria baicalensis Georgi (Wogon). Yakugaku Zasshi 100:1220–1224

    PubMed  CAS  Google Scholar 

  13. Takagi S, Yamaki M, Inoue K (1981) On the minor constituents of the roots of Scutellaria baicalensis Georgi (Wogon). Yakugaku Zasshi 101:899–903

    PubMed  CAS  Google Scholar 

  14. Tomimori T, Miyaichi Y, Kizu H (1982) On the flavonoid constituents from the roots of Scutellaria baicalensis Georgi. I. Yakugaku Zasshi 102:388–391

    CAS  Google Scholar 

  15. Tomimori T, Miyaichi Y, Imoto Y, Kizu H, Suzuki C (1984) Studies on the constituents of Scutellaria species. IV. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (4). Yakugaku Zasshi 104:529–534

    PubMed  CAS  Google Scholar 

  16. Tomimori T, Miyaichi Y, Imoto Y, Kizu H, Tanabe Y (1984) Studies on the constituents of Scutellaria species. III. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (3). Yakugaku Zasshi 104:524–528

    PubMed  CAS  Google Scholar 

  17. Tomimori T, Jin H, Miyaichi Y, Toyofuku S, Namba T (1985) Studies on the constituents of Scutellaria species. VI. On the flavonoid constituents of the root of Scutellaria baicalensis Georgi (5). Quantitative analysis of flavonoids in Scutellaria roots by high-performance liquid chromatography. Yakugaku Zasshi 105:148–155

    PubMed  CAS  Google Scholar 

  18. Tani T, Katsuki T, Kubo M, Arichi S (1985) Histochemistry. VII. Flavones in Scutellariae radix. Chem Pharm Bull (Tokyo) 33:4894–4900

    Article  CAS  Google Scholar 

  19. Takido M, Aimi M, Yamanouchi S, Yasukawa K, Torii H, Takahashi S (1976) Studies on the constituents in the water extracts of crude drugs. II. On the leaves of Scutellaria baicalensis Georgi (1). Yakugaku Zasshi 96:381–383

    PubMed  CAS  Google Scholar 

  20. Nagai T, Miyaichi Y, Tomimori T, Yamada H (1989) Inhibition of mouse liver sialidase by plant flavonoids. Biochem Biophys Res Commun 3:25–31

    Article  Google Scholar 

  21. Tsao T-F, Newman MG, Kwok Y-Y, Horikoshi AK (1982) Effect of Chinese and western antimicrobial agents on selected oral bacteria. J Dent Res 61:1103–1106

    Article  PubMed  CAS  Google Scholar 

  22. Kato M, Marumoto M, Hayashi M, Maeda T, Hayashi E (1984) Pharmacological studies on Saiko-prescriptions. IV. Effect of Shosaiko-to on swelling of rat hind paws induced by carrageenin. Yakugaku Zasshi 104:509–515

    PubMed  CAS  Google Scholar 

  23. Kato M, Marumoto M, Hayashi M, Maeda T, Hayashi E (1984) Pharmacological studies on Saiko-prescriptions. V. Mechanisms of actions of Shosaiko-to on swelling of rat hind paws induced by carrageenin. Yakugaku Zasshi 104:516–523

    PubMed  CAS  Google Scholar 

  24. Kubo M, Matsuda H, Tanaka M, et al. (1984) Studies on Scutellariae radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellariae radix. Chem Pharm Bull (Tokyo) 32:2724–2729

    Article  CAS  Google Scholar 

  25. Koda A, Nishiyori T, Nagai H, Matsuura N, Tsuchiya H (1982) Anti-allergic actions of crude drugs and blended Chinese traditional medicines. Effects of type I and type IV allergic reactions. Folia Pharmacol Jpn 80:41

    Article  Google Scholar 

  26. Nagasawa T, Shibutani S, Oura H (1979) Effect of crude drugs on rat serum constituents after the administration. II. Yakugaku Zasshi 99:71–77

    PubMed  CAS  Google Scholar 

  27. Kimura Y, Kubo M, Tani T, Arichi S, Ohminami H, Okuda H (1981) Studies on Scutellariae radix. III. Effects on lipid metabolism in serum, liver and fat cells of rats. Chem Pharm Bull (Tokyo) 29:2308–2312

    Article  CAS  Google Scholar 

  28. Kimura Y, Kubo M, Kusaka K, Tani T, Higashino M, Arichi S, Okuda H (1982) Studies on Scutellariae radix. V. Effects on ethanol-induced hyperlipemia and lipolysis in isolated fat cells. Chem Pharm Bull (Tokyo) 30:219–222

    Article  CAS  Google Scholar 

  29. Tani T, Ohno T, Inoue K, Katsuki T, Arichi S (1986) Effect of crude drugs and their prescriptions on the blood rheology affected by glucocorticoid treatment. IV. Effect of Sho-saiko-to Dai-saiko-to and their constituent crude drugs on adverse reactions in betamethasone treated rat. Yakugaku Zasshi 106:808–817

    PubMed  CAS  Google Scholar 

  30. Kubo M, Matsuda H, Tani T, Arichi S, Kimura Y, Okuda H (1985) Studies on Scutellariae radix. XII. Anti-thrombotic actions of various flavonoids from Scutellariae radix. Chem Pharm Bull (Tokyo) 33:2411–2415

    Article  CAS  Google Scholar 

  31. Nagai T, Yamada H, Otsuka Y (1989) Inhibition of mouse liver sialidase by the root of Scutellaria baicalensis. Planta Med 55:27–29

    Article  PubMed  CAS  Google Scholar 

  32. Kiso Y, Suzuki M, Yasuda M, Watanabe H, Minegishi T, Hikino H, Yang L-L, Yen K-Y (1990) Antihepatotoxic actions of traditional Chinese medicines. 2. The pharmacological interaction of components of Dai-saiko-to employing complement-mediated cytotoxicity in primary cultured mouse hepatocytes. Phytother Res 4:36–38

    Article  Google Scholar 

  33. Kimura Y, Kubo M, Tani T, Arichi S, Okuda H (1981) Studies on Scutellariae radix. IV. Effects on lipid peroxidation in rat liver. Chem Pharm Bull (Tokyo) 29:2610–2617

    Article  Google Scholar 

  34. Kimura Y, Okuda H, Tani T, Arichi S (1982) Studies on Scutellariae radix. VI. Effects of flavanone compounds on lipid peroxidation in rat liver. Chem Pharm Bull (Tokyo) 30:1792–1795

    Article  CAS  Google Scholar 

  35. Kimura Y, Okuda H, Taira Z, Shoji N, Takemoto T, Arichi S (1984) Studies on Scutellariae radix. IX. New component inhibiting lipid peroxidation in rat liver. Planta Med 50:290–295

    Article  PubMed  CAS  Google Scholar 

  36. Friedman FK, West D, Sugimura T, Gelboin HV (1985) Flavone modulators of rat hepatic aryl hydrocarbon hydroxylase. Pharmacology 31:203–207

    Article  PubMed  CAS  Google Scholar 

  37. Duval D, Hodnick WF, Pardini RS (1988) Inhibition of mitochondrial respiration, auto-oxidation and cyanide mediated oxygen consumption by selected flavonoids. Fed Am Soc Exp Biol J 2(4):A773

    Google Scholar 

  38. Nikaido T, Ohmoto T, Kinoshita T, et al. (1989) Inhibition of adenosine 3’,5’-cyclic monophosphate phosphodiesterase by flavonoids. III. Chem Pharm Bull (Tokyo) 37:1392–1395

    Article  CAS  Google Scholar 

  39. Higashitani A, Tabata S, Hayashi T, Hotta Y (1989) Plant saponins can affect DNA recombination in cultured mammalian cells. Cell Struct Funct 14:617–624

    Article  PubMed  CAS  Google Scholar 

  40. Sakai Y, Nagase H, Ose Y, Sato T, Kawai M, Mizuno M (1988) Effects of medicinal plant extracts from Chinese herbal medicines on the mutagenic activity of benzo[a]pyrene. Mutat Res 206:327–334

    Article  PubMed  CAS  Google Scholar 

  41. Abe K, Inoue O, Yumioka E (1990) Biliary excretion of metabolites of baicalin and baicalein in rats. Chem Pharm Bull (Tokyo) 38:208–211

    Article  CAS  Google Scholar 

  42. Kiwaki S, Ono C, Sakai K, Tada H, Oketani Y (1989) Ninety-day toxicity study of a Chinese herb medicine, Sairei-tô extract in rats. Pharmacometrics 38:241–254

    Google Scholar 

  43. Kiwaki S, Yamashita Y, Yamamae H, Nakamura T, Oketani Y (1989) Ninety-day toxicity study of a Chinese herb medicine Saiboku-to extract in rats. Pharmacometrics 38:495–510

    Google Scholar 

  44. Harvey J, Colin-Jones DG (1981) Mistletoe hepatitis. Br Med J 282:186–187

    Article  CAS  Google Scholar 

  45. MacGregor FB, Abernethy VE, Dahabra S, Cobden I, Hayes PC (1989) Hepatotoxicity of herbal remedies. Br Med J 299:1156–1157

    Article  CAS  Google Scholar 

  46. Weeks GR, Proper JS (1989) Herbal medicines — Gaps in our knowledge. Aust J Hosp Pharm 19:155–157

    Google Scholar 

  47. Fletcher Hyde F (1981) Mistletoe hepatitis. Br Med J 282:739

    Article  Google Scholar 

  48. Farnsworth NR, Loub WD (1981) Mistletoe hepatitis. Br Med J 282:1058

    Article  Google Scholar 

  49. McIntyre M (1984) Exposed: the inaccurate reporting behind the herbal medicine “scare”. J Altern Med, January, pp 2–3

    Google Scholar 

  50. Myhr K. Department of Pharmacy, University Hospital of Trondheim. Personal communications, September and November 1991

    Google Scholar 

  51. Leander S, Skogstrom L. Naturmedisin kan gi leverskade. Aflenposten November 6, 1991

    Google Scholar 

  52. Mourn B, Aukrust P, Schrumpf E, Mork T, Mathisen O, Elgjo K (1992) Naturmidier kan forârsake helseskader. Tidsskr Nor Laegeforen 112:1308–1311

    Google Scholar 

  53. Nolan JE, Brain KR (1985) Component interaction in Chinese herbal medicines. Acta Agronom 34 (Suppl):113

    Google Scholar 

  54. Matsui AS, Rogers J, Woo YK, Cutting WC (1967) Effects of some natural products on fertility in mice. Med Pharmacol Exp Int J Exp Med 16:414–424

    PubMed  CAS  Google Scholar 

  55. Kiwaki S, Ono C, Sakai K, Nakamura T, Oketani Y (1989) A teratological evaluation of orally administered Sairei-tô extract in rats. Pharmacometrics 38:255–270

    Google Scholar 

  56. Kim SH, Kim Y-H, Han S-S, Roh JK (1988) Reproduction (Seg. II) study of Scutellaria radix in rat. J Toxicol Sci 13:340

    Google Scholar 

  57. Morimoto I, Watanabe F, Osawa T, Okitsu T (1982) Mutagenicity screening of crude drugs with Bacillus subtilis rec-assay and Salmonella/microsome reversion assay. Mutat Res 97:81–102

    PubMed  CAS  Google Scholar 

  58. Yamamoto H, Mizutani T, Nomura H (1982) Studies on the mutagenicity of crude drug extracts. I. Yakugaku Zasshi 102:596–601

    CAS  Google Scholar 

  59. Lee HK, Kim YK, Kim Y-H, Roh JK (1987) Effect of bacterial growth-inhibiting ingredients on the Ames mutagenicity of medicinal herbs. Mutat Res 192:99–104

    Article  PubMed  CAS  Google Scholar 

  60. Nagao M, Morita N, Yahagi T, et al. (1981) Mutagenicities of 61 flavonoids and 11 related compounds. Environ Mut 3:401–419

    Article  CAS  Google Scholar 

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Authors
  1. P. A. G. M. De Smet
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Editors and Affiliations

  1. Drug Information Center, Royal Dutch Association for the Advancement of Pharmacy, Alexanderstraat 11, 2514 JL, The Hague, The Netherlands

    Peter A. G. M. De Smet

  2. Institut für Arzneimittel des Bundesgesundheitsamtes, Seestraße 10, 13353, Berlin, Germany

    Konstantin Keller

  3. Westpreußenstraße 71, 81927, München, Germany

    Rudolf Hänsel

  4. College of Pharmacy, Dalhousie University, Halifax, B3H 3J5, Canada

    R. Frank Chandler

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© 1993 Springer-Verlag Berlin Heidelberg

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De Smet, P.A.G.M. (1993). Scutellaria Species. In: De Smet, P.A.G.M., Keller, K., Hänsel, R., Chandler, R.F. (eds) Adverse Effects of Herbal Drugs 2. Adverse Effects of Herbal Drugs, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48906-8_24

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  • DOI: https://doi.org/10.1007/978-3-642-48906-8_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55800-2

  • Online ISBN: 978-3-642-48906-8

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